Ralph B D’agostino
Datos Biográficos
| ID | 3476497 |
|---|---|
| NOMBRE | Ralph B D’agostino |
| NOMBRES | Ralph B |
| APELLIDO | D’agostino |
| FIRMA | D’AGOSTINO R B |
| AFILIACIONES | Boston University |
| ORCID | 0000-0002-3550-8395 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 37 |
| TOTAL DE CITAS | 44 |
| TOTAL COMO AUTOR | 37 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 1970 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2026 |
| ÍNDICE H | 4 |
Muscle quality during cancer treatment and associations with health-related quality of life
Muscle quality worsened over 24-months and trended toward worse physical function at 24-months follow-up. From initial declines during treatment, participants reported recovered HRQoL by 24-months. Further work in a larger cohort is needed to confirm associations with muscle quality and physical function
Selecting External Controls for Internal Cases Using Stratification Score Matching Methods
Rare-disease registries can be useful for studying the associations between environmental exposures and disease severity, but often require the addition of a healthy comparison control group. Defining a surrogate control group, matched and balanced on potentially confounding variables, would allow for the comparison of exposure distributions with cases from a registry. In the present study, we assess whether controls selected externally, using st…
Methodological Challenges and Statistical Approaches in the COMprehensive Post-Acute Stroke Services Study
BACKGROUND: The COMprehensive Post-Acute Stroke Services study was a cluster-randomized pragmatic trial designed to evaluate a comprehensive care transitions model versus usual care. The data collected during this trial were complex and analysis methodology was required that could simultaneously account for the cluster-randomized design, missing patient-level covariates, outcome nonresponse, and substantial nonadherence to the intervention. OBJEC…
Physical distancing interventions and incidence of coronavirus disease 2019
Effects of Weather on Coronavirus Pandemic
The novel coronavirus (SARS-CoV-2) has spread globally and has been declared a pandemic by the World Health Organization. While influenza virus shows seasonality, it is unknown if COVID-19 has any weather-related affect. In this work, we analyze the patterns in local weather of all the regions affected by COVID-19 globally. Our results indicate that approximately 85% of the COVID-19 reported cases until 1 May 2020, making approximately 3 million …
World Health Organization cardiovascular disease risk charts
BACKGROUND: To help adapt cardiovascular disease risk prediction approaches to low-income and middle-income countries, WHO has convened an effort to develop, evaluate, and illustrate revised risk models. Here, we report the derivation, validation, and illustration of the revised WHO cardiovascular disease risk prediction charts that have been adapted to the circumstances of 21 global regions. METHODS: In this model revision initiative, we derived…
Neighborhood characteristics, food deserts, rurality, and type 2 diabetes in youth
The Contribution of Autonomic Imbalance to the Development of Metabolic Syndrome
OBJECTIVES: Obesity, diabetes, and heart disease-the most costly epidemics of our time-share a common but rarely treated mechanism: autonomic imbalance. We examined the contribution of autonomic imbalance, relative to selected demographic and biobehavioral risk factors, to the development of metabolic syndrome in a community sample for 12 years. METHODS: We identified offspring cohort participants from the Framingham Heart Study who did not have …
Association of Cardiometabolic Multimorbidity With Mortality
IMPORTANCE The prevalence of cardiometabolic multimorbidity is increasing. OBJECTIVE To estimate reductions in life expectancy associated with cardiometabolic multimorbidity. DESIGN, SETTING, AND PARTICIPANTS Age-and sex-adjusted mortality rates and hazard ratios (HRs) were calculated using individual participant data from the Emerging Risk Factors Collaboration (689 300 participants; 91 cohorts; years of baseline surveys: 1960-2007; latest morta…
"Causes" Of Pesticide Safety Behavior Change in Latino Farmworker Families
The conceptual targets of the La Familia Sana program explained the greatest amount of change in pesticide-related behavior. Promotora attributes also contributed to intervention success
Patterns of weight change and progression to overweight and obesity differ in men and women
Objective To evaluate long-term patterns of weight change and progression to overweight and obesity during adulthood. Design Prospective study. Changes in mean BMI, waist circumference (WC) and weight were assessed over a mean 26-year follow-up (1971–1975 to 1998–2001). Mean BMI (95 % CI) and mean WC (95 % CI) of men and women in BMI and age groups were computed. Mean weight change in BMI and age categories was compared using analysis of covarian…
Migration Status in Relation to Clinical Characteristics and Barriers to Care Among Youth with Diabetes in the US
Evaluating geographic variation in type 1 and type 2 diabetes mellitus incidence in youth in four US regions
General Cardiovascular Risk Profile for Use in Primary Care
Background— Separate multivariable risk algorithms are commonly used to assess risk of specific atherosclerotic cardiovascular disease (CVD) events, ie, coronary heart disease, cerebrovascular disease, peripheral vascular disease, and heart failure. The present report presents a single multivariable risk function that predicts risk of developing all CVD and of its constituents. Methods and Results— We used Cox proportional-hazards regression to e…
Temporal Trends in Self-Reported Functional Limitations and Physical Disability Among the Community-Dwelling Elderly Population
Objectives. We sought to determine change in the prevalence of functional limitations and physical disability among the community-dwelling elderly population across 3 decades. Methods. We studied original participants of the Framingham Heart Study, aged 79 to 88 years, at examination 15 (1977–1979; 177 women, 103 men), examination 20 (1988–1990; 159 women, 98 men) and examination 25 (1997–1999; 174 women, 119 men). Self-reported functional limita…
Marital Status, Marital Strain, and Risk of Coronary Heart Disease or Total Mortality
OBJECTIVE: To determine if marriage and marital strain are related to the 10-year coronary heart disease (CHD) incidence or total mortality. Research has demonstrated associations between marital strain and prognosis of heart disease, but little research has addressed the association between specific aspects of marital strain and incident CHD. METHODS: From 1984 to 1987, 3682 participants (mean age 48.5 +/- 10.1 (standard deviation) years; 52% wo…
Validity of an adaptation of the Framingham cardiovascular risk function
Background: To assess the reliability and accuracy of the Framingham coronary heart disease (CHD) risk function adapted by the Registre Gironí del Cor (REGICOR) investigators in Spain. Methods: A 5-year follow-up study was completed in 5732 participants aged 35–74 years. The adaptation consisted of using in the function the average population risk factor prevalence and the cumulative incidence observed in Spain instead of those from Framingham in…
Social Networks and Inflammatory Markers in the Framingham Heart Study
Lack of social integration predicts coronary heart disease mortality in prospective studies; however, the biological pathways that may be responsible are poorly understood. The specific aims of this study were to examine whether social networks are associated with serum concentrations of the inflammatory markers interleukin-6 (IL-6), C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant protein…
Serum Cholesterol and Cognitive Performance in the Framingham Heart Study
OBJECTIVE: The objective of this study was to examine the relationship between total cholesterol (TC) and cognitive performance within the context of the Framingham Heart Study, a large, community-based, prospective investigation of cardiovascular risk factors. METHODS: Participants were 789 men and 1105 women from the Framingham Heart Study original cohort who were free of dementia and stroke and who received biennial TC determinations over a 16…
Tension and Anxiety and the Prediction of the 10-Year Incidence of Coronary Heart Disease, Atrial Fibrillation, and Total Mortality
OBJECTIVE: Conflicting research findings regarding the ability of tension or anxiety to predict incident coronary heart disease (CHD) have created uncertainty in the literature. In addition, there are no prospective studies relating these characteristics to the development of atrial fibrillation (AF). METHODS: From 1984 to 1987, 3682 participants (mean age 48.5 +/- 10.1 year; 52% women) of the Framingham Offspring Study were examined and followed…
Does Hospitalization Impact Survival After Lower Respiratory Infection in Nursing Home Residents
BACKGROUND: Lower respiratory infection (LRI) is the leading cause of hospitalization for nursing home residents, but hospitalization is costly and may cause complications. OBJECTIVE: We sought to compare mortality and cost between episodes of LRI initially treated in the hospital versus the nursing home after controlling for illness severity and the probability of hospitalization. DESIGN: This was a prospective cohort study of nursing home resid…
Cervical Cancer Risk as a Predictor of Pap Smear Use in Rural North Carolina
Risk for invasive cervical cancer is reported to be higher in rural areas than urban ones, and cervical cancer‐related mortality is higher in rural women due to poorer utilization of preventive services and subsequent presentation at late stages of the disease. This cross‐sectional study examined the relationship between prevalence of risk factors for cervical cancer and the degree of compliance with risk‐appropriate screening guidelines for cerv…
Validation of the Framingham Coronary Heart Disease Prediction Scores
CONTEXT: The Framingham Heart Study produced sex-specific coronary heart disease (CHD) prediction functions for assessing risk of developing incident CHD in a white middle-class population. Concern exists regarding whether these functions can be generalized to other populations. OBJECTIVE: To test the validity and transportability of the Framingham CHD prediction functions per a National Heart, Lung, and Blood Institute workshop organized for thi…
Prediction of Coronary Heart Disease Using Risk Factor Categories
Background —The objective of this study was to examine the association of Joint National Committee (JNC-V) blood pressure and National Cholesterol Education Program (NCEP) cholesterol categories with coronary heart disease (CHD) risk, to incorporate them into coronary prediction algorithms, and to compare the discrimination properties of this approach with other noncategorical prediction functions. Methods and Results —This work was designed as a…
Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group
In observational studies, investigators have no control over the treatment assignment. The treated and non-treated (that is, control) groups may have large differences on their observed covariates, and these differences can lead to biased estimates of treatment effects. Even traditional covariance analysis adjustments may be inadequate to eliminate this bias. The propensity score, defined as the conditional probability of being treated given the …
Job strain and health-related quality of life in a national sample
OBJECTIVES. Studies of the health effects of job strain have focused on morbidity and mortality as outcomes. This is the first study to examine the relationship of job strain to more comprehensive health status measures that encompass health-related quality of life. METHODS. In a national cross-sectional survey, 1319 working men and women, aged 18 through 64 years, completed a modified version of the Job Content Questionnaire that classified work…
Functional limitations and disability among elders in the Framingham Study
BACKGROUND. The measurement of physical disability as an indication of the impact of disease is commonly seen in research. However, these measures often do not clearly differentiate between functional limitations and daily performance of an activity. METHODS. We measured the differences between self-reported disability and observed functional limitations in six activities of daily living tasks among community-dwelling elders. The value of functio…
How Important is Functional Status as a Predictor of Service Use by Older People
In studies of older people, it is often assumed that biophysical, or functional, status is the primary determinant of formal service use. This article reports baseline data from a longitudinal study of a community-based, linked random sample of frail elders (n = 635) and their informal caregivers (n = 429) to investigate the relative contribution of social circumstances to the use of community-based formal services. Elder respondents were categor…
Evaluating geographic variation in type 1 and type 2 diabetes mellitus incidence in youth in four US regions
Temporal Trends in Self-Reported Functional Limitations and Physical Disability Among the Community-Dwelling Elderly Population
Objectives. We sought to determine change in the prevalence of functional limitations and physical disability among the community-dwelling elderly population across 3 decades. Methods. We studied original participants of the Framingham Heart Study, aged 79 to 88 years, at examination 15 (1977–1979; 177 women, 103 men), examination 20 (1988–1990; 159 women, 98 men) and examination 25 (1997–1999; 174 women, 119 men). Self-reported functional limita…
Social indicators
Neighborhood characteristics, food deserts, rurality, and type 2 diabetes in youth
Validity of an adaptation of the Framingham cardiovascular risk function
Background: To assess the reliability and accuracy of the Framingham coronary heart disease (CHD) risk function adapted by the Registre Gironí del Cor (REGICOR) investigators in Spain. Methods: A 5-year follow-up study was completed in 5732 participants aged 35–74 years. The adaptation consisted of using in the function the average population risk factor prevalence and the cumulative incidence observed in Spain instead of those from Framingham in…
Is coronary-care-unit admission restricted for elderly patients? A multicenter study
BACKGROUND. To investigate whether elderly patients are more likely to experience restricted access to high technology medical care, we examined the impact of age on the likelihood of coronary care unit (CCU) admission for patients with acute myocardial infarction. METHODS. As part of a prospective investigation of emergency room triage for patients with suspected cardiac ischemia, we studied 4223 patients presenting to six hospitals. Because CCU…
Simple compact portable test of normality
Simple compact portable test of normality
Test of normality against skewed alternatives
The 27 Percent Rule Revisited
The problem of selecting the size of the tails from a sample drawn from a distribution of test scores for item analysis study is discussed. In the past the selected tails were viewed as independent samples. However, this is not the case. The tails are dependent. Given this we find that each tail should contain about 21% of the sample and not the traditional 27%. Use of 27%, however, is not far from optimal
Social indicators
A randomized control trial of cardiac rehabilitation
A Suggestion for Using Powerful and Informative Tests of Normality
For testing that an underlying population is normally distributed the skewness and kurtosis statistics, √b 1 and b 2, and the D'Agostino–Pearson K 2 statistic that combines these two statistics have been shown to be powerful and informative tests. Their use, however, has not been as prevalent as their usefulness. We review these tests and show how readily available and popular statistical software can be used to implement them. Their relationship…
How Important is Functional Status as a Predictor of Service Use by Older People
In studies of older people, it is often assumed that biophysical, or functional, status is the primary determinant of formal service use. This article reports baseline data from a longitudinal study of a community-based, linked random sample of frail elders (n = 635) and their informal caregivers (n = 429) to investigate the relative contribution of social circumstances to the use of community-based formal services. Elder respondents were categor…
Is coronary-care-unit admission restricted for elderly patients? A multicenter study
BACKGROUND. To investigate whether elderly patients are more likely to experience restricted access to high technology medical care, we examined the impact of age on the likelihood of coronary care unit (CCU) admission for patients with acute myocardial infarction. METHODS. As part of a prospective investigation of emergency room triage for patients with suspected cardiac ischemia, we studied 4223 patients presenting to six hospitals. Because CCU…
Functional limitations and disability among elders in the Framingham Study
BACKGROUND. The measurement of physical disability as an indication of the impact of disease is commonly seen in research. However, these measures often do not clearly differentiate between functional limitations and daily performance of an activity. METHODS. We measured the differences between self-reported disability and observed functional limitations in six activities of daily living tasks among community-dwelling elders. The value of functio…
Job strain and health-related quality of life in a national sample
OBJECTIVES. Studies of the health effects of job strain have focused on morbidity and mortality as outcomes. This is the first study to examine the relationship of job strain to more comprehensive health status measures that encompass health-related quality of life. METHODS. In a national cross-sectional survey, 1319 working men and women, aged 18 through 64 years, completed a modified version of the Job Content Questionnaire that classified work…
A Time-Insensitive Predictive Instrument for Acute Hospital Mortality Due to Congestive Heart Failure
The purpose of this study was to develop a "time-insensitive" predictive instrument (TIPI) for acute hospital mortality due to congestive heart failure. In Phase 1, based on prospectively collected data on 401 congestive heart failure patients among 5,773 study patients who presented to six New England hospitals over a 2-year period whose chief complaints were chest pain, shortness of breath, or other cardiac symptoms, a multivariable logistic re…
Breaking With Tradition
Chronic shortages of registered nurses (RNs) have stimulated interest in locating non-traditional sources of RNs. A statewide survey of 2,315 newly graduated RNs compared three non-traditional groups in nursing with their traditional counterparts, identifying differences that have implications for successful recruitment and retention. Second career nurses, former LPNs and minorities comprised 41.9% of the population. Compared to the traditional g…
Prediction of Coronary Heart Disease Using Risk Factor Categories
Background —The objective of this study was to examine the association of Joint National Committee (JNC-V) blood pressure and National Cholesterol Education Program (NCEP) cholesterol categories with coronary heart disease (CHD) risk, to incorporate them into coronary prediction algorithms, and to compare the discrimination properties of this approach with other noncategorical prediction functions. Methods and Results —This work was designed as a…
Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group
In observational studies, investigators have no control over the treatment assignment. The treated and non-treated (that is, control) groups may have large differences on their observed covariates, and these differences can lead to biased estimates of treatment effects. Even traditional covariance analysis adjustments may be inadequate to eliminate this bias. The propensity score, defined as the conditional probability of being treated given the …
Validation of the Framingham Coronary Heart Disease Prediction Scores
CONTEXT: The Framingham Heart Study produced sex-specific coronary heart disease (CHD) prediction functions for assessing risk of developing incident CHD in a white middle-class population. Concern exists regarding whether these functions can be generalized to other populations. OBJECTIVE: To test the validity and transportability of the Framingham CHD prediction functions per a National Heart, Lung, and Blood Institute workshop organized for thi…
Cervical Cancer Risk as a Predictor of Pap Smear Use in Rural North Carolina
Risk for invasive cervical cancer is reported to be higher in rural areas than urban ones, and cervical cancer‐related mortality is higher in rural women due to poorer utilization of preventive services and subsequent presentation at late stages of the disease. This cross‐sectional study examined the relationship between prevalence of risk factors for cervical cancer and the degree of compliance with risk‐appropriate screening guidelines for cerv…
Does Hospitalization Impact Survival After Lower Respiratory Infection in Nursing Home Residents
BACKGROUND: Lower respiratory infection (LRI) is the leading cause of hospitalization for nursing home residents, but hospitalization is costly and may cause complications. OBJECTIVE: We sought to compare mortality and cost between episodes of LRI initially treated in the hospital versus the nursing home after controlling for illness severity and the probability of hospitalization. DESIGN: This was a prospective cohort study of nursing home resid…
Serum Cholesterol and Cognitive Performance in the Framingham Heart Study
OBJECTIVE: The objective of this study was to examine the relationship between total cholesterol (TC) and cognitive performance within the context of the Framingham Heart Study, a large, community-based, prospective investigation of cardiovascular risk factors. METHODS: Participants were 789 men and 1105 women from the Framingham Heart Study original cohort who were free of dementia and stroke and who received biennial TC determinations over a 16…
Tension and Anxiety and the Prediction of the 10-Year Incidence of Coronary Heart Disease, Atrial Fibrillation, and Total Mortality
OBJECTIVE: Conflicting research findings regarding the ability of tension or anxiety to predict incident coronary heart disease (CHD) have created uncertainty in the literature. In addition, there are no prospective studies relating these characteristics to the development of atrial fibrillation (AF). METHODS: From 1984 to 1987, 3682 participants (mean age 48.5 +/- 10.1 year; 52% women) of the Framingham Offspring Study were examined and followed…
Social Networks and Inflammatory Markers in the Framingham Heart Study
Lack of social integration predicts coronary heart disease mortality in prospective studies; however, the biological pathways that may be responsible are poorly understood. The specific aims of this study were to examine whether social networks are associated with serum concentrations of the inflammatory markers interleukin-6 (IL-6), C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant protein…
Marital Status, Marital Strain, and Risk of Coronary Heart Disease or Total Mortality
OBJECTIVE: To determine if marriage and marital strain are related to the 10-year coronary heart disease (CHD) incidence or total mortality. Research has demonstrated associations between marital strain and prognosis of heart disease, but little research has addressed the association between specific aspects of marital strain and incident CHD. METHODS: From 1984 to 1987, 3682 participants (mean age 48.5 +/- 10.1 (standard deviation) years; 52% wo…
Validity of an adaptation of the Framingham cardiovascular risk function
Background: To assess the reliability and accuracy of the Framingham coronary heart disease (CHD) risk function adapted by the Registre Gironí del Cor (REGICOR) investigators in Spain. Methods: A 5-year follow-up study was completed in 5732 participants aged 35–74 years. The adaptation consisted of using in the function the average population risk factor prevalence and the cumulative incidence observed in Spain instead of those from Framingham in…
General Cardiovascular Risk Profile for Use in Primary Care
Background— Separate multivariable risk algorithms are commonly used to assess risk of specific atherosclerotic cardiovascular disease (CVD) events, ie, coronary heart disease, cerebrovascular disease, peripheral vascular disease, and heart failure. The present report presents a single multivariable risk function that predicts risk of developing all CVD and of its constituents. Methods and Results— We used Cox proportional-hazards regression to e…
Temporal Trends in Self-Reported Functional Limitations and Physical Disability Among the Community-Dwelling Elderly Population
Objectives. We sought to determine change in the prevalence of functional limitations and physical disability among the community-dwelling elderly population across 3 decades. Methods. We studied original participants of the Framingham Heart Study, aged 79 to 88 years, at examination 15 (1977–1979; 177 women, 103 men), examination 20 (1988–1990; 159 women, 98 men) and examination 25 (1997–1999; 174 women, 119 men). Self-reported functional limita…
Evaluating geographic variation in type 1 and type 2 diabetes mellitus incidence in youth in four US regions
Medicine (31 obras) · Environmental health (15 obras) · Internal Medicine (15 obras) · Internal Medicine (14 obras) · Disease (12 obras) · Population (12 obras) · Demography (11 obras) · Gerontology (11 obras) · Mathematics (10 obras) · Psychology (10 obras)