Andrew Sherwood
Datos Biográficos
| ID | 5120106 |
|---|---|
| NOMBRE | Andrew Sherwood |
| NOMBRES | Andrew |
| APELLIDO | Sherwood |
| FIRMA | SHERWOOD A |
| AFILIACIONES | University of North Carolina at Chapel Hill |
| ORCID | 0000-0001-9067-185X |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 38 |
| TOTAL DE CITAS | 57 |
| TOTAL COMO AUTOR | 38 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 1989 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2017 |
| ÍNDICE H | 2 |
Lifestyle and Neurocognition in Older Adults With Cardiovascular Risk Factors and Cognitive Impairment
OBJECTIVE: The aim of the study was to determine the relationship of lifestyle factors and neurocognitive functioning in older adults with vascular risk factors and cognitive impairment, no dementia (CIND). METHODS: One hundred sixty adults (M [SD] = 65.4 [6.8] years) with CIND completed neurocognitive assessments of executive function, processing speed, and memory. Objective measures of physical activity using accelerometry, aerobic capacity det…
Trauma and Autonomic Dysregulation
OBJECTIVE: Posttraumatic stress disorder (PTSD) has been linked to elevated heart rate (HR) and reduced heart rate variability (HRV) in cross-sectional research. Recent evidence suggests that this link may be driven by individual differences in autonomic arousal associated with momentary negative affect (NA). Using ecological momentary assessment (EMA) of NA and minute-to-minute HR/HRV monitoring, we examined whether NA-related HR/HRV mediated th…
Impact of Racial Discrimination and Hostility on Adrenergic Receptor Responsiveness in African American Adults
These findings suggest racial discrimination was associated with blunted β-adrenergic receptor responsiveness, providing further evidence of the potential contribution of racial discrimination to increased CVD risk among African Americans. The adverse effects of discrimination on cardiovascular health may be enhanced in individuals with higher levels of hostility
Effects of Exercise and Sertraline on Measures of Coronary Heart Disease Risk in Patients With Major Depression
OBJECTIVE: To assess the effects of supervised and home-based aerobic exercise training, and antidepressant pharmacotherapy (sertraline) on coronary heart disease (CHD) risk factors in a sample of participants with major depressive disorder (MDD). METHODS: The Standard Medical Intervention versus Long-term Exercise (SMILE)-II study randomized 202 adults (153 women, 49 men) diagnosed as having MDD to one of four interventions, each of 4-month dura…
Examining the Crux of Autonomic Dysfunction in Posttraumatic Stress Disorder
OBJECTIVE: Posttraumatic stress disorder (PTSD) has been linked to elevated heart rate (HR) and reduced heart rate variability (HRV) in cross-sectional research. Using ecological momentary assessment and minute-to-minute HRV/HR monitoring, we examined whether cross-sectional associations between PTSD symptom severity and HRV/HR were due to overall elevations in distress levels or to attenuated autonomic regulation during episodes of acute distres…
Association of Depressive and Anxiety Symptoms With 24-Hour Urinary Catecholamines in Individuals With Untreated High Blood Pressure
OBJECTIVE: Depression and anxiety are considered risk factors for cardiovascular disease (CVD). The explanatory mechanisms, however, are still to be characterized. One proposed pathophysiological pathway is dysregulation of the autonomic nervous system, including heightened sympathetic nervous system activity. This study examined the relationship between symptoms of depression, anxiety, and sympathetic nervous system activity in individuals with …
Posttraumatic Stress, Heart Rate Variability, and the Mediating Role of Behavioral Health Risks
OBJECTIVE: Posttraumatic stress disorder (PTSD) has been linked to reduced heart rate variability (HRV), which is in turn a risk factor for cardiovascular disease and death. Although hyperarousal and anxiety are thought to underlie this association, behavioral health risks, including smoking, alcohol dependence, obesity, and sleep disturbance, represent potential mechanisms linking PTSD and HRV. METHODS: To test this hypothesis, short-term labora…
Orthostatic hypotension in young adults with and without posttraumatic stress disorder
The purpose of this research is (a) to evaluate differences in orthostatic hypotension (OH) among young adults with and without posttraumatic stress disorder (PTSD) and (b) to examine whether group differences may be attributable to behavioral risk factors frequently associated with PTSD. Volunteers and U.S. veterans 18 to 39 years old (N = 222) completed a semistructured interview assessment of PTSD status. Direct measurements were obtained for …
Household Responsibilities, Income, and Ambulatory Blood Pressure Among Working Men and Women
OBJECTIVE: To test the hypothesis that a greater perceived responsibility for household tasks and a greater number of hours spent doing these tasks would be associated with elevated ambulatory systolic (SBP) and diastolic blood pressure (DBP). The connection between job characteristics and cardiovascular outcomes has been widely studied. However, less is known about links between household work characteristics and cardiovascular health. METHODS: …
Exercise and Pharmacotherapy in Patients With Major Depression
OBJECTIVE: To examine a 1-year follow-up of a 4-month, controlled clinical trial of exercise and antidepressant medication in patients with major depressive disorder (MDD). METHODS: In the original study, 202 sedentary adults with MDD were randomized to: a) supervised exercise; b) home-based exercise; c) sertraline; or d) placebo pill. We examined two outcomes measured at 1-year follow-up (i.e., 16 months post randomization): 1) continuous Hamilt…
The role of melanin concentrating hormone (MCH) in reward learning
Aerobic Exercise and Neurocognitive Performance
OBJECTIVES: To assess the effects of aerobic exercise training on neurocognitive performance. Although the effects of exercise on neurocognition have been the subject of several previous reviews and meta-analyses, they have been hampered by methodological shortcomings and are now outdated as a result of the recent publication of several large-scale, randomized, controlled trials (RCTs). METHODS: We conducted a systematic literature review of RCTs…
An analysis of licking microstructure in three strains of mice
Response to Letters to the Editor
Blumenthal, James A. PhD; Sherwood, Andrew PhD; Babyak, Michael A. PhD; Doraiswamy, P Murali MD; Hoffman, Benson M. PhD For the SMILE Investigators Author Information
Cerebrovascular Risk Factors, Vascular Disease, and Neuropsychological Outcomes in Adults With Major Depression
Objective: To investigate the relationship of cerebrovascular risk factors (CVRFs), endothelial function, carotid artery intima medial thickness (IMT), and neuropsychological performance in a sample of 198 middle-aged and older individuals with major depressive disorder (MDD). Neuropsychological deficits are common among adults with MDD, particularly among those with CVRFs and potentially persons with subclinical vascular disease. Methods: CVRFs …
Exercise and Pharmacotherapy in the Treatment of Major Depressive Disorder
OBJECTIVE: To assess whether patients receiving aerobic exercise training performed either at home or in a supervised group setting achieve reductions in depression comparable to standard antidepressant medication (sertraline) and greater reductions in depression compared to placebo controls. METHODS: Between October 2000 and November 2005, we performed a prospective, randomized controlled trial (SMILE study) with allocation concealment and blind…
Social Support and Coronary Heart Disease
Objective: The present paper reviews theories of social support and evidence for the role of social support in the development and progression of coronary heart disease (CHD). Methods: Articles for the primary review of social support as a risk factor were identified with MEDLINE (1966–2004) and PsychINFO (1872–2004). Reviews of bibliographies also were used to identify relevant articles. Results: In general, evidence suggests that low social sup…
Emotional Antecedents of Hot Flashes During Daily Life
OBJECTIVE: Hot flashes are among the most frequently reported menopausal symptoms. However, little is known about factors associated with their occurrence. Moreover, despite the wide use of self-report hot flash measures, little is known about their concordance with physiological flashes. This study evaluated emotional and behavioral antecedents of subjectively and objectively measured hot flashes during daily life. It also examined individual di…
Hostility, Coronary Risk, and Α-Adrenergic to Β-Adrenergic Receptor Density Ratio
Sherwood, Andrew PhD; Hughes, Joel W. PhD; Blumenthal, James A. PhD; Suarez, Edward C. PhD; Hinderliter, Alan L. MD Author Information
Depression as a Risk Factor for Coronary Artery Disease
OBJECTIVE: The present paper reviews the evidence that depression is a risk factor for the development and progression of coronary artery disease (CAD). METHODS: MEDLINE searches and reviews of bibliographies were used to identify relevant articles. Articles were clustered by theme: depression as a risk factor, biobehavioral mechanisms, and treatment outcome studies. RESULTS: Depression confers a relative risk between 1.5 and 2.0 for the onset of…
Hostility Is Related to Blunted β-Adrenergic Receptor Responsiveness Among Middle-Aged Women
OBJECTIVE: Based on previous findings in men, the hypothesis that hostility would be associated with blunted responsiveness of cardiovascular beta-adrenergic receptors was tested in a study sample of middle-aged women. The roles of the sympathetic nervous system and of social support in this putative relationship were also evaluated. METHODS: Subjects were 80 healthy women (n = 23 African American; n = 57 white), aged 47 to 55 years. Hostility wa…
Biological Correlates of Abuse in Women with Premenstrual Dysphoric Disorder and Healthy Controls
OBJECTIVE: To examine the biological correlates associated with histories of sexual or physical abuse in women meeting DSM criteria for premenstrual dysphoric disorder (PMDD) and in healthy, non-PMDD controls. METHODS: Twenty-eight women with prospectively confirmed PMDD were compared with 28 non-PMDD women for cardiovascular and neuroendocrine measures at rest and in response to mental stressors, and for beta-adrenergic receptor responsivity, du…
Hostility, Social Support, and Adrenergic Receptor Responsiveness Among African-American and White Men and Women
OBJECTIVE: We examined the relationship between beta-adrenergic receptor responsiveness and hostility and social support in African American and white men and women. METHODS: The participants were 149 men and women, aged 25 to 45 years with SBP < 160 and DBP < 105. Hostility and social support were assessed with standardized self-report measures. An isoproterenol challenge was used to evaluate beta-adrenergic receptor responsiveness, and a phenyl…
Effects of Perceived Racism and Anger Inhibition on Ambulatory Blood Pressure in African Americans
Perceived racism and anger inhibition are independently related to higher ABP. Both may contribute to the incidence of hypertension and hypertensive-related diseases observed in African Americans
Relationship of Clinic, Ambulatory, and Laboratory Stress Blood Pressure to Left Ventricular Mass in Overweight Men and Women With High Blood Pressure
OBJECTIVE: This study was designed to evaluate the relationship between left ventricular (LV) mass and blood pressure (BP) recorded in the following contexts: in the clinic, using standard auscultatory procedures, during a typical day using ambulatory BP monitoring, and in the laboratory environment during behavioral stress testing. METHODS: Ninety-seven men and women with clinic systolic blood pressure (SBP) of 130 to 180 mm Hg and/or diastolic …
Effects of Perceived Racism and Anger Inhibition on Ambulatory Blood Pressure in African Americans
Perceived racism and anger inhibition are independently related to higher ABP. Both may contribute to the incidence of hypertension and hypertensive-related diseases observed in African Americans
Impact of Racial Discrimination and Hostility on Adrenergic Receptor Responsiveness in African American Adults
These findings suggest racial discrimination was associated with blunted β-adrenergic receptor responsiveness, providing further evidence of the potential contribution of racial discrimination to increased CVD risk among African Americans. The adverse effects of discrimination on cardiovascular health may be enhanced in individuals with higher levels of hostility
An analysis of licking microstructure in three strains of mice
Effects of aerobic exercise training on hemodynamic responses during psychosocial stress in normotensive and borderline hypertensive type A men
This study assessed the effects of aerobic exercise training on cardiovascular responses to a 5-min reaction time competition task. Twenty-seven Type A men (aged 30-56) participated in this randomized study in which 14 underwent supervised aerobic training and 13 strength training, with sessions scheduled three times per week for 12 consecutive weeks. Aerobic exercise training was associated with a 13.6% increase in VO2max compared to 2.9% for th…
Methodological Guidelines for Impedance Cardiography
Impedance cardiography was introduced over 20 years ago as a noninvasive and unobtrusive technique for measuring systolic time intervals and cardiac output. Although our understanding of the physiological events reflected in the impedance cardiogram has become more refined, the technique's theoretical basis remains somewhat controversial and acceptance of its validity has relied heavily upon empirical validation. Largely as a consequence of this …
Gender differences in blood pressure control during a variety of behavioral stressors
This study assessed gender differences in hemodynamic response patterns to behavioral stressors. In addition, the extent to which gender differences in cardiovascular reactivity were a function of the type of challenge was determined by employing tasks relying on stereotypically male areas of competence and a task relying on stereotypically female areas of competence. Sixteen female and 15 male graduate, medical or dental students were exposed to…
Cardiovascular responses to an active coping challenge as predictors of blood pressure patterns 10 to 15 years later
To assess the long-term predictive importance of high cardiovascular reactivity in relation to subsequent blood pressure, 51 men from a pool of 204 men originally tested at age 18 to 22 years were recruited for blood pressure assessment 10 to 15 years later. Initial testing uniformly involved monitoring of systolic pressure, diastolic pressure, and heart rate during a reaction time task involving threat of shock. In 30 of the 51 men who participa…
Anxiety and Vagal Control of Heart Rate
OBJECTIVE: Prospective studies have demonstrated that anxiety predicts sudden cardiac death, but the mechanism underlying this increased risk is unclear. This study examined whether anxiety is associated with reductions in vagal control of heart rate in healthy volunteers. METHOD: Trait anxiety (T-ANX) was measured, using the Spielberger State-Trait Anxiety Inventory (STAI), in 93 healthy men and women 25 to 44 years of age. Power spectral analys…
Neuroendocrine Factors in Premenstrual Dysphoric Disorder
Girdler, S.; Sherwood, A.; Hinderliter, A.; Stanwyck, C.; Pedersen, C.; Maixner, W.; Light, K. Author Information
Depression Predicts Left Ventricular Hypertrophy in Hypertensive Individuals
Gullette, Elizabeth C. D.; Babyak, Michael A.; Sherwood, Andrew; Hinderliter, Alan; Blumenthal, James A. Author Information
Blood Pressure Reactivity and Marital Distress in Employed Women
OBJECTIVE: The impact of marital distress on cardiovascular responses to an "ecologically valid" laboratory stressor (a marital conflict recall task) was examined in maritally distressed and non-distressed women. It was hypothesized that the presence of high levels of marital distress would be associated with elevated blood pressure and heart rate responses to a marital conflict task. METHOD: Fifty married, employed women, aged 25-45, were recrui…
Cardiovascular Reactivity and Left Ventricular Mass in Hypertensive Men and Women
Gullette, E. D.; Blumenthal, J. A.; Hinderliter, A. L.; Babyak, M. A.; Waugh, R.; Sherwood, A. Author Information
Endothelial Function and Hemodynamic Responses During Mental Stress
OBJECTIVE: The hemodynamic basis of blood pressure responses during psychological stress shows striking individual differences that share an interesting similarity with risk for cardiovascular disease. Factors accounting for these individual differences are poorly understood. The present study examined the relationship of vascular endothelial function to stress-induced hemodynamic responses. METHODS: Subjects were 40 healthy men and women, aged 2…
Psychometric properties of the Social Phobia Inventory (SPIN)
BACKGROUND: Of available self-rated social phobia scales, none assesses the spectrum of fear, avoidance, and physiological symptoms, all of which are clinically important. Because of this limitation, we developed the Social Phobia Inventory (SPIN). AIMS: To establish psychometric validation of the SPIN. METHOD: Subjects from three clinical trials and two control groups were given the 17-item, self-rated SPIN. Validity was assessed against several…
Ambulatory Blood Pressure and Marital Distress in Employed Women
In this investigation, the relationship between marital distress and blood pressure during daily life in a sample of married employed women was examined. It was hypothesized that greater marital distress would be associated with elevated blood pressure in the home environment, but not in the workplace. Participants were 50 married employed women, aged 25 to 45 years. Participants underwent ambulatory blood pressure monitoring on a typical workday…
Religious Coping, Ethnicity, and Ambulatory Blood Pressure
OBJECTIVE: To investigate the relationship between religious coping, ethnicity, and ambulatory blood pressure (ABP) measured during daily life. METHODS: A 24-hour ABP was obtained from 155 men and women (78 African American and 77 white) on a typical workday. ABP was averaged over awake and sleep periods, and clinic BP was also assessed. Psychosocial measures of coping style, negative affect, social support, stress, and health behaviors were comp…
Relationship of Clinic, Ambulatory, and Laboratory Stress Blood Pressure to Left Ventricular Mass in Overweight Men and Women With High Blood Pressure
OBJECTIVE: This study was designed to evaluate the relationship between left ventricular (LV) mass and blood pressure (BP) recorded in the following contexts: in the clinic, using standard auscultatory procedures, during a typical day using ambulatory BP monitoring, and in the laboratory environment during behavioral stress testing. METHODS: Ninety-seven men and women with clinic systolic blood pressure (SBP) of 130 to 180 mm Hg and/or diastolic …
Biological Correlates of Abuse in Women with Premenstrual Dysphoric Disorder and Healthy Controls
OBJECTIVE: To examine the biological correlates associated with histories of sexual or physical abuse in women meeting DSM criteria for premenstrual dysphoric disorder (PMDD) and in healthy, non-PMDD controls. METHODS: Twenty-eight women with prospectively confirmed PMDD were compared with 28 non-PMDD women for cardiovascular and neuroendocrine measures at rest and in response to mental stressors, and for beta-adrenergic receptor responsivity, du…
Hostility, Social Support, and Adrenergic Receptor Responsiveness Among African-American and White Men and Women
OBJECTIVE: We examined the relationship between beta-adrenergic receptor responsiveness and hostility and social support in African American and white men and women. METHODS: The participants were 149 men and women, aged 25 to 45 years with SBP < 160 and DBP < 105. Hostility and social support were assessed with standardized self-report measures. An isoproterenol challenge was used to evaluate beta-adrenergic receptor responsiveness, and a phenyl…
Effects of Perceived Racism and Anger Inhibition on Ambulatory Blood Pressure in African Americans
Perceived racism and anger inhibition are independently related to higher ABP. Both may contribute to the incidence of hypertension and hypertensive-related diseases observed in African Americans
Hostility, Coronary Risk, and Α-Adrenergic to Β-Adrenergic Receptor Density Ratio
Sherwood, Andrew PhD; Hughes, Joel W. PhD; Blumenthal, James A. PhD; Suarez, Edward C. PhD; Hinderliter, Alan L. MD Author Information
Depression as a Risk Factor for Coronary Artery Disease
OBJECTIVE: The present paper reviews the evidence that depression is a risk factor for the development and progression of coronary artery disease (CAD). METHODS: MEDLINE searches and reviews of bibliographies were used to identify relevant articles. Articles were clustered by theme: depression as a risk factor, biobehavioral mechanisms, and treatment outcome studies. RESULTS: Depression confers a relative risk between 1.5 and 2.0 for the onset of…
Hostility Is Related to Blunted β-Adrenergic Receptor Responsiveness Among Middle-Aged Women
OBJECTIVE: Based on previous findings in men, the hypothesis that hostility would be associated with blunted responsiveness of cardiovascular beta-adrenergic receptors was tested in a study sample of middle-aged women. The roles of the sympathetic nervous system and of social support in this putative relationship were also evaluated. METHODS: Subjects were 80 healthy women (n = 23 African American; n = 57 white), aged 47 to 55 years. Hostility wa…
Social Support and Coronary Heart Disease
Objective: The present paper reviews theories of social support and evidence for the role of social support in the development and progression of coronary heart disease (CHD). Methods: Articles for the primary review of social support as a risk factor were identified with MEDLINE (1966–2004) and PsychINFO (1872–2004). Reviews of bibliographies also were used to identify relevant articles. Results: In general, evidence suggests that low social sup…
Emotional Antecedents of Hot Flashes During Daily Life
OBJECTIVE: Hot flashes are among the most frequently reported menopausal symptoms. However, little is known about factors associated with their occurrence. Moreover, despite the wide use of self-report hot flash measures, little is known about their concordance with physiological flashes. This study evaluated emotional and behavioral antecedents of subjectively and objectively measured hot flashes during daily life. It also examined individual di…
Cerebrovascular Risk Factors, Vascular Disease, and Neuropsychological Outcomes in Adults With Major Depression
Objective: To investigate the relationship of cerebrovascular risk factors (CVRFs), endothelial function, carotid artery intima medial thickness (IMT), and neuropsychological performance in a sample of 198 middle-aged and older individuals with major depressive disorder (MDD). Neuropsychological deficits are common among adults with MDD, particularly among those with CVRFs and potentially persons with subclinical vascular disease. Methods: CVRFs …
Exercise and Pharmacotherapy in the Treatment of Major Depressive Disorder
OBJECTIVE: To assess whether patients receiving aerobic exercise training performed either at home or in a supervised group setting achieve reductions in depression comparable to standard antidepressant medication (sertraline) and greater reductions in depression compared to placebo controls. METHODS: Between October 2000 and November 2005, we performed a prospective, randomized controlled trial (SMILE study) with allocation concealment and blind…
Response to Letters to the Editor
Blumenthal, James A. PhD; Sherwood, Andrew PhD; Babyak, Michael A. PhD; Doraiswamy, P Murali MD; Hoffman, Benson M. PhD For the SMILE Investigators Author Information
Medicine (36 obras) · Internal Medicine (34 obras) · Internal Medicine (32 obras) · Psychology (29 obras) · Blood pressure (21 obras) · Clinical Psychology (18 obras) · Heart Rate Variability and Autonomic Control (16 obras) · Psychiatry (15 obras) · Stress Responses and Cortisol (13 obras) · Cardiac Health and Mental Health (12 obras)