George P Chrousos
Datos Biográficos
| ID | 5758804 |
|---|---|
| NOMBRE | George P Chrousos |
| NOMBRES | George P |
| APELLIDO | Chrousos |
| FIRMA | CHROUSOS G P |
| AFILIACIONES | National and Kapodistrian University of Athens |
| ORCID | 0000-0002-3098-5264 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 45 |
| TOTAL DE CITAS | 81 |
| TOTAL COMO AUTOR | 45 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 1985 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2025 |
| ÍNDICE H | 5 |
A comprehensive mechanism of biological and health effects of anthropogenic extremely low frequency and wireless communication electromagnetic fields
Exposure to anthropogenic electromagnetic fields (EMFs), especially those of wireless communications (WC) has increased tremendously. This is an unprecedented phenomenon throughout biological evolution because, all anthropogenic EMFs, being fully polarized, coherent, and, especially WC EMFs, highly variable, differ substantially from the natural EMFs. WC EMFs consist of Microwave (MW) carrier waves, modulated, by Extremely Low Frequency (ELF) sig…
Validity and Reliability of the Multidimensional Scale of Perceived Social Support (MSPSS) in Greek Secondary School Students
Background/Objectives : Resilience-a complex phenomenon embracing a number of factors on various levels-seems to be a most important skill to survive this vulnerable phase. One major factor is the perceived social support during adolescence. Recognizing gaps in perceived social support may lead to prevention of serious social and medical problems, including juvenile delinquency and stress-related diseases. Screening questionnaires to identify the…
The Validity and Reliability of the Short Form of the Adolescent Stress Questionnaire (ASQ-14) Among Greek Adolescents Aged 15–18
The Greek ASQ-14 emerges as a psychometrically sound tool for screening stress among Greek adolescents
Validation of Perceived Stress Scale-10 Among Greek Middle Adolescents
Stress significantly impacts adolescents’ health. Therefore, its measurement is of critical importance. This study aims to assess the psychometric properties of a Greek adolescent version of PSS-10 among middle adolescents. This study’s questionnaire, which was completed by 169 adolescents aged 15–18, included a Greek linguistic, cultural, and age-appropriate version of the PSS-10 and the validated Greek ASQ version. Confirmatory factor and explo…
Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli
This pilot repeated measures study aims to evaluate the dynamics of the autonomic nervous system (ANS), the hypothalamic-pituitary-adrenal (HPA) axis, and/or their interplay with low-level inflammation in healthy schoolchildren during consecutive extrinsic stimuli. Twenty healthy schoolchildren and adolescents aged 11-14 years (12.5 ± 1.5) were consecutively exposed to an oral task (#2) and an arithmetic task (#3) (Trier Social Stress Test for Ch…
Reliability and Validity of the Educational Stress Scale for Adolescents (Essa) in a Sample of Greek Students
This research outlines the initial validation of a new instrument to quantify academic stress, the Educational Stress Scale for Adolescents (ESSA). A total of 399 students (61.9% females, 38.1% males), with a mean age of 16.3 years, participated in the research protocol. Cronbach's α for the total 16-item ESSA scale was 0.878, suggesting good reliability. Cronbach's α for each one of the five components were statistically positively significant. …
Educational Stress among Greek Adolescents
Greek adolescent students experience high levels of educational stress during the school period. In this cross-sectional study, we examined various factors associated with educational stress in Greece. The study was conducted using a self-report questionnaire survey in Athens, Greece, between November 2021 and April 2022. We studied a sample of 399 students (61.9% females; 38.1% males, with a mean age of 16.3 years). We found that several factors…
Soft Tissue Ewing Sarcoma Cell Drug Resistance Revisited
Ewing sarcoma is a rare type of cancer that develops in the bones and soft tissues. Drug therapy represents an extensively used modality for the treatment of sarcomas. However, cancer cells tend to develop resistance to antineoplastic agents, thereby posing a major barrier in treatment effectiveness. Thus, there is a need to uncover the molecular mechanisms underlying chemoresistance in sarcomas and, hence, to enhance the anticancer treatment out…
Strong Correlations between Social Appearance Anxiety, Use of Social Media, and Feelings of Loneliness in Adolescents and Young Adults
Social appearance anxiety is a type of social anxiety that is associated with body image perception and exacerbated by the use of social media, leading to feelings of loneliness. The purpose of this cross-sectional study was to examine the relations between social appearance anxiety, use of social media, and feelings of loneliness in Greek adolescents and young adults. The sample of the research consisted of 632 participants, 439 women (69.5%) an…
Stress and Well-Being of Greek Primary School Educators
The teaching profession has always been challenging, while for various reasons the magnitude of observed stress in teachers has been continually growing over time. This study was conducted to demonstrate the relevance of stress in this professional group and to generate evidence for the benefit of primary school teachers and, indirectly, their pupils. To this end, we examined a large number of school teachers in a descriptive cross-sectional stud…
Circulating FGF21 vs. Stress Markers in Girls during Childhood and Adolescence, and in Their Caregivers
Fibroblast growth factor-21 (FGF21) acts on several brain regions, including the hypothalamic paraventricular nucleus, which is involved in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis. The purpose of this study was to investigate the interrelations between FGF21 and stress indices in girls, as well as in their caregivers. 78 girls, aged between 5 and 15 years, were studied; 50 of them were overweight and obese (OB) and 28 in t…
Comparison of Hospital Consultation and Summer Camp Lifestyle Intervention Programs for Sustained Body Weight Loss in Overweight/Obese Greek Children
Two lifestyle intervention programs of a health initiative named "Evrostia" were conducted at (a) an outpatient obesity clinic of a children's hospital and (b) summer camp (SC), respectively. Thirty overweight/obese children were randomly selected to participate in each intervention arm to assess the efficacy of the SC intervention and its possible superiority over usual hospital consultation (HC) practice. There was a statistically significant d…
The Effect of Pythagorean Self-Awareness on Heart Rate Variability, Perceived Stress and Behavior of Preschool Children
Stress is associated with unhealthy habits and non-communicable diseases. It is also linked to communicable diseases due to its impact on immune function. These can be prevented through intervention programs in schools. The aim of this study was to examine the effect of the simplified Pythagorean Self-Awareness Intervention on heart rate variability (HRV) parameters, perceived stress and behaviors of preschool children. The sample of the study co…
Stress, Inflammation and Metabolic Biomarkers Are Associated with Body Composition Measures in Lean, Overweight, and Obese Children and Adolescents
The aim of this study was to examine the associations between multiple indices of stress, inflammation and metabolism vs. body composition parameters in 121 (43 boys, 78 girls) children and adolescents, aged 5-15 y. Subjects were divided into two groups: normal weight (N) (N = 40, BMI z-score = -0.1923 ± 0.6), and overweight/obese (OB) (N = 81, BMI z-score = 2.1947 ± 1.4). All subjects completed the State-Trait Anxiety Inventory for Children (STA…
Associations between Maternal and Offspring Hair Cortisol Concentrations and Child Behavioral Symptoms in Mother-Child Pairs with Perinatal Mental Disorders
Maternal perinatal mental disorders (PMD) are associated with developmental and behavioral problems in children, probably mediated by the programming of the hypothalamic-pituitary-adrenal (HPA) axis. Increased cortisol concentrations during the antenatal and perinatal periods have been related to long-term effects on children's behavior and stress response. We aimed to investigate the association of hair cortisol concentrations (HCC) between moth…
Could Covid-19′s Aftermath on Children’s Health Be Felt into the 22nd Century
The COVID-19 pandemic has massively affected people's health, societies, and the global economy. Our lives are no longer as they were before COVID-19, and, most likely, will never be the same again. We hypothesize that the effect of the COVID-19 pandemic on population health and the economy will last for a very long time and will still be felt in the 22nd century. Our hypothesis is based on evidence from the 1918-1919 influenza pandemic, the Dutc…
An Integrated Study of the Mesolithic Skeleton in Theopetra Cave, Greece
Skeletal evidence dating back to the Mesolithic period is scarce and should be studied under a multidisciplinary perspective. The primary objective of the study was to carefully assess the skeleton of a young woman from this era, named “Avgi,” to compile its bioarchaeological profile, analyze its paleopathology and dental pathology, and deploy a 3D reconstruction and modeling method in order to reveal her face. Both demographic and pathological i…
Dietary Sugar Intake and Its Association with Obesity in Children and Adolescents
Sugar intake has been associated with increased prevalence of childhood overweight/obesity; however, results remain controversial. The aim of this study was to examine the probability of overweight/obesity with higher sugar intakes, accounting for other dietary intakes. Data from 1165 children and adolescents aged ≥2-18 years (66.8% males) enrolled in the Hellenic National Nutrition and Health Survey (HNNHS) were used; specifically, 781 children …
Increased Serum Concentrations of High Mobility Group Box 1 (HMGB1) Protein in Children with Autism Spectrum Disorder
High mobility group box 1 protein (HMGB1) has been suggested to be involved in the immune dysfunction and inflammation reported in autism spectrum disorder (ASD). We aimed to assess HMGB1 serum concentrations (SCs) in high-functioning ASD children compared to typically developing (TD) controls and to explore their associations with the autism spectrum quotient (AQ), the empathy quotient (EQ), and the systemizing quotient (SQ). The study involved …
Low- and High-Attenuation Lung Volume in Quantitative Chest CT in Children without Lung Disease
In contrast to studies of adults with emphysema, application of fixed thresholds to determine low- and high-attenuation areas (air-trapping and parenchymal lung disease) in pediatric quantitative chest CT is problematic. We aimed to assess age effects on: (i) mean lung attenuation (full inspiration); and (ii) low and high attenuation thresholds (LAT and HAT) defined as mean attenuation and 1 SD below and above mean, respectively. Chest CTs from c…
Lamotrigine Reduces Stress Symptoms of Chronic Anxiety in the Times of the Covid-19 Natural Catastrophe-A Case Report
The SARS-CoV-2 pandemic has been a worldwide chronic, stress-inducing natural catastrophe associated with increased emotional challenging. Patients with Post-traumatic stress disorder (PTSD), self-injury behavior, and obesity are predisposed to aggravation of their symptoms at this time, requiring new therapeutic approaches to balance their disrupted neuro-hormonal stress axis. Here we present our observations of an off-label treatment with lamot…
Metabolic Profiling Indicates Diversity in the Metabolic Physiologies Associated With Maternal Postpartum Depressive Symptoms
Background: Postpartum depression (PPD) is a devastating disease requiring improvements in diagnosis and prevention. Blood metabolomics identifies biological markers discriminatory between women with and those without antenatal depressive symptoms. Whether this cutting-edge method can be applied to postpartum depressive symptoms merits further investigation. Methods: As a substudy within the Biology, Affect, Stress, Imagine and Cognition Study, 2…
Perinatal, sociodemographic and lifestyle correlates of increased total and visceral fat mass levels in schoolchildren in Greece
Objective To identify possibly independent associations of perinatal, sociodemographic and lifestyle factors with childhood total and visceral body fat. Design A representative sample of 2655 schoolchildren (9–13 years) participated in the Healthy Growth Study, a cross-sectional epidemiological study. Setting Seventy-seven primary schools in four large regions in Greece. Subjects A sample of 1228 children having full data on total and visceral fa…
Stress Management and Intimate Partner Violence
Perceived Stress Scores among Saudi Students Entering Universities
In this prospective study we wanted to determine whether perceived stress over time among students in the Preparatory Year of King Saud University (KSU) predisposes them to cardiometabolic abnormalities. A total of 110 apparently healthy Saudi students (35 men and 75 women enrolled during the 2010-2011 academic year) were included. Perceived stress was determined at baseline and 1 year later. Anthropometrics were obtained and morning fasting seru…
Perceptions of puberty
Relations between hormone levels and observational measures of aggressive behavior of young adolescents in family interactions
Negative affect and hormone levels in young adolescents
The relation of relative hormonal levels and physical development and social-emotional behavior in young adolescents
Cortisol Reactivity, Distress Behavior, and Behavioral and Psychological Problems in Young Adolescents
Cortisol levels, observed distress behavior, behavior problems, and symptoms of anxiety and depression are examined in young adolescents. The longitudinal design consists of three times of measurement, at 6-month intervals. We (1) examine covariations among cortisol level and extent of distress behavior in adolescents experiencing a challenging situation, (2) identify intraindividual patterns of change in cortisol level (cortisol reactivity) duri…
Stress Management and Intimate Partner Violence
Variability in Hormone Concentrations and Self-Reported Menstrual Histories in Young Adolescents
An Integrated Study of the Mesolithic Skeleton in Theopetra Cave, Greece
Skeletal evidence dating back to the Mesolithic period is scarce and should be studied under a multidisciplinary perspective. The primary objective of the study was to carefully assess the skeleton of a young woman from this era, named “Avgi,” to compile its bioarchaeological profile, analyze its paleopathology and dental pathology, and deploy a 3D reconstruction and modeling method in order to reveal her face. Both demographic and pathological i…
The relation of relative hormonal levels and physical development and social-emotional behavior in young adolescents
The Progesterone Antagonist RU 486
Relations between hormone levels and observational measures of aggressive behavior of young adolescents in family interactions
Perceptions of puberty
“Environmental stress” and reproductive success in the common marmoset ( Callithrix jacchus jacchus )
The present report documents the breeding success of a new colony of common marmosets ( Callithrix jacchus jacchus ) and demonstrates a correlation between environmental stress and reproductive success. Environmental conditions ranged chronologically over 40 months, through four periods: I) the initial period, when the colony was formed; II) a phase of relative environmental stability; III) a stage of “environmental stress” (when the colony was d…
Negative affect and hormone levels in young adolescents
The Concepts of Stress and Stress System Disorders
Objective. —This article defines stress and related concepts and reviews their historical development. The notion of a stress system as the effector of the stress syndrome is suggested, and its physiologic and pathophysiologic manifestations are described. A new perspective on human disease states associated with dysregulation of the stress system is provided. Data Sources. —Published original articles from human and animal studies and selected r…
Cortisol Reactivity, Distress Behavior, and Behavioral and Psychological Problems in Young Adolescents
Cortisol levels, observed distress behavior, behavior problems, and symptoms of anxiety and depression are examined in young adolescents. The longitudinal design consists of three times of measurement, at 6-month intervals. We (1) examine covariations among cortisol level and extent of distress behavior in adolescents experiencing a challenging situation, (2) identify intraindividual patterns of change in cortisol level (cortisol reactivity) duri…
Maternal Depression and Risk for Postpartum Complications
The pregnancies of 58 healthy adolescents (ages 13 to 19 years) were followed to examine links between symptoms of depression, corticotropin-releasing hormone (CRH), interleukin-1 beta, (IL-1 beta), and IL-1 receptor antagonist (IL-1ra) as possible predictors of maternal and infant outcomes. Maternal psychological adjustment and medical complications during gestation, labor, delivery, and the postpartum period were monitored. Plasma samples colle…
Variability in Hormone Concentrations and Self-Reported Menstrual Histories in Young Adolescents
Hypothalamic–pituitary–adrenal axis, neuroendocrine factors and stress
Endocrinology of the Stress Response
The stress response is subserved by the stress system, which is located both in the central nervous system and the periphery. The principal effectors of the stress system include corticotropin-releasing hormone (CRH); arginine vasopressin; the proopiomelanocortin-derived peptides α-melanocyte-stimulating hormone and β-endorphin, the glucocorticoids; and the catecholamines norepinephrine and epinephrine. Appropriate responsiveness of the stress sy…
Stress and disorders of the stress system
Perceived Stress Scale
The Greek versions of the PSS-14 and PSS-10 exhibited satisfactory psychometric properties and their use for research and health care practice is warranted
Use of a Relaxation Technique by Mothers of Children with Autism
Mothers of children with autism are subject to considerable stress by having to adjust to the disorder and to cope with practical and social issues. Evidence on the effects of relaxation training on stress of these mothers is scarce. The purpose of this pilot case-series study was to examine the role of a simple 6-week daily stress management technique on mothers of children with autism. Mothers' stress measurements and children's functionality w…
Psychosocial and cognitive function in children with nephrotic syndrome
BACKGROUND: To investigate possible differences in emotional/behavioral problems and cognitive function in children with nephrotic syndrome compared to healthy controls and to examine the effect of disease-specific and steroid treatment-specific characteristics on the abovementioned variables. METHODS: Forty-one patients with nephrotic syndrome (23 boys, age range: 4.4-15.2 years) and 42 sex- and age-matched healthy control subjects (20 boys, age…
Perceived Stress Scores among Saudi Students Entering Universities
In this prospective study we wanted to determine whether perceived stress over time among students in the Preparatory Year of King Saud University (KSU) predisposes them to cardiometabolic abnormalities. A total of 110 apparently healthy Saudi students (35 men and 75 women enrolled during the 2010-2011 academic year) were included. Perceived stress was determined at baseline and 1 year later. Anthropometrics were obtained and morning fasting seru…
Stress and cardiometabolic manifestations among Saudi students entering universities
Perceived stress is alarmingly high among Saudi students entering universities. This study sheds light on the social responsibility of universities in promoting a healthy lifestyle, particularly in this age group, when exposure to different kinds of stressors may result in body weight and metabolic changes
The Healthy Lifestyle and Personal Control Questionnaire (HLPCQ)
The HLPCQ is a good tool for assessing the efficacy of future health-promoting interventions to improve individuals' lifestyle and wellbeing
Identification of lifestyle patterns associated with obesity and fat mass in children
Objective To investigate possible associations of lifestyle patterns with obesity and fat mass in children. Design Cross-sectional epidemiological study. Principal component analysis was used to identify lifestyle patterns. Setting Primary schools from four regions in Greece. Subjects A total of 2073 schoolchildren (aged 9–13 years). Results Children in the fourth quartile of the lifestyle pattern combining higher dairy foods with more adequate b…
Dietary patterns and breakfast consumption in relation to insulin resistance in children. The Healthy Growth Study
Objective Insulin resistance is a significant cross-point for the manifestation of several chronic diseases in children and adults. The aim of the present study was to investigate the possible relationship of certain dietary patterns and breakfast consumption habits with insulin resistance in children. Subjects A representative sample of 1912 schoolchildren (aged 9–13 years) participated in a cross-sectional epidemiological study, the Healthy Gro…
Stress Management and Intimate Partner Violence
Perinatal, sociodemographic and lifestyle correlates of increased total and visceral fat mass levels in schoolchildren in Greece
Objective To identify possibly independent associations of perinatal, sociodemographic and lifestyle factors with childhood total and visceral body fat. Design A representative sample of 2655 schoolchildren (9–13 years) participated in the Healthy Growth Study, a cross-sectional epidemiological study. Setting Seventy-seven primary schools in four large regions in Greece. Subjects A sample of 1228 children having full data on total and visceral fa…
Dietary Sugar Intake and Its Association with Obesity in Children and Adolescents
Sugar intake has been associated with increased prevalence of childhood overweight/obesity; however, results remain controversial. The aim of this study was to examine the probability of overweight/obesity with higher sugar intakes, accounting for other dietary intakes. Data from 1165 children and adolescents aged ≥2-18 years (66.8% males) enrolled in the Hellenic National Nutrition and Health Survey (HNNHS) were used; specifically, 781 children …
Increased Serum Concentrations of High Mobility Group Box 1 (HMGB1) Protein in Children with Autism Spectrum Disorder
High mobility group box 1 protein (HMGB1) has been suggested to be involved in the immune dysfunction and inflammation reported in autism spectrum disorder (ASD). We aimed to assess HMGB1 serum concentrations (SCs) in high-functioning ASD children compared to typically developing (TD) controls and to explore their associations with the autism spectrum quotient (AQ), the empathy quotient (EQ), and the systemizing quotient (SQ). The study involved …
Medicine (37 obras) · Psychology (27 obras) · Internal Medicine (20 obras) · Clinical Psychology (17 obras) · Clinical Psychology (15 obras) · Stress Responses and Cortisol (15 obras) · Biology (12 obras) · Developmental psychology (12 obras) · Psychiatry (12 obras) · Child and Adolescent Psychosocial and Emotional Development (10 obras)