Isaac Ssewanyana
Datos Biográficos
| ID | 7002869 |
|---|---|
| NOMBRE | Isaac Ssewanyana |
| NOMBRES | Isaac |
| APELLIDO | Ssewanyana |
| FIRMA | SSEWANYANA I |
| AFILIACIONES | Ministry of Health |
| ORCID | 0000-0001-8605-2001 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 6 |
| TOTAL DE CITAS | 0 |
| TOTAL COMO AUTOR | 6 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 2023 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2026 |
| ÍNDICE H | 0 |
Imported malaria predominates in near-elimination settings in Southwestern Uganda
Malaria transmission in southwestern Uganda is low, but persists despite control efforts. Identifying whether infections are locally sustained or imported by travelers is critical for guiding interventions. We integrated epidemiologic surveillance with parasite genomics to characterize imported malaria episodes at three health facilities in southwestern Uganda. Between January 2023 and June 2024, we enrolled microscopy-confirmed malaria cases at …
Optimizing hepatitis B diagnosis for mothers in a low-resource setting
Mother-to-child transmission accounts for most new hepatitis B (HBV) infections in high-burden regions globally. The World Health Organization recommends antiviral prophylaxis for pregnant women with high hepatitis B viral load levels, but access to viral load testing remains limited and untimely in many countries, due to centralized testing. We assessed the operational feasibility, accessibility, and cost of implementing the Xpert HBV DNA assay …
Wastewater-based surveillance as a proactive public health tool
Wastewater-based surveillance offers a cost-effective, population-level complement to clinical testing for early detection of infectious disease outbreaks; however, its adoption in low- and middle-income countries remains limited. We conducted a study in Kampala, Uganda, to quantify SARS-CoV-2 RNA in wastewater and evaluate its association with reported clinical cases, thereby strengthening community-level surveillance strategies. From March 2023…
The epidemiology of antibiotic-resistant clinical pathogens in Uganda
Background: Antibiotic resistance (ABR) is a global challenge, and its control depends on robust evidence primarily derived from surveillance systems. Methods: We utilised a national surveillance data set to demonstrate how such evidence can be systematically generated. In doing so, we characterised the ABR profiles of priority clinical pathogens, identified associated factors, and drew inferences on antibiotic usage in Uganda. Results: Of the 12…
Uptake and effectiveness of a mobile application for real-time reporting and quality assurance of decentralized Sars-CoV-2 testing in Uganda
Background: Effective management of the COVID-19 pandemic required rapid expansion of diagnosis. The introduction of antigen tests presented an opportunity to decentralize testing, but raised challenges with ensuring accurate and timely reporting of testing data, which is essential to guide the response. Digital solutions can help address this challenge and provide more efficient means of monitoring and quality assurance. Methods: Uganda's existi…
Metagenomic next-generation sequencing to characterize potential etiologies of non-malarial fever in a cohort living in a high malaria burden area of Uganda
Causes of non-malarial fevers in sub-Saharan Africa remain understudied. We hypothesized that metagenomic next-generation sequencing (mNGS), which allows for broad genomic-level detection of infectious agents in a biological sample, can systematically identify potential causes of non-malarial fevers. The 212 participants in this study were of all ages and were enrolled in a longitudinal malaria cohort in eastern Uganda. Between December 2020 and …
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Uptake and effectiveness of a mobile application for real-time reporting and quality assurance of decentralized Sars-CoV-2 testing in Uganda
Background: Effective management of the COVID-19 pandemic required rapid expansion of diagnosis. The introduction of antigen tests presented an opportunity to decentralize testing, but raised challenges with ensuring accurate and timely reporting of testing data, which is essential to guide the response. Digital solutions can help address this challenge and provide more efficient means of monitoring and quality assurance. Methods: Uganda's existi…
Metagenomic next-generation sequencing to characterize potential etiologies of non-malarial fever in a cohort living in a high malaria burden area of Uganda
Causes of non-malarial fevers in sub-Saharan Africa remain understudied. We hypothesized that metagenomic next-generation sequencing (mNGS), which allows for broad genomic-level detection of infectious agents in a biological sample, can systematically identify potential causes of non-malarial fevers. The 212 participants in this study were of all ages and were enrolled in a longitudinal malaria cohort in eastern Uganda. Between December 2020 and …
The epidemiology of antibiotic-resistant clinical pathogens in Uganda
Background: Antibiotic resistance (ABR) is a global challenge, and its control depends on robust evidence primarily derived from surveillance systems. Methods: We utilised a national surveillance data set to demonstrate how such evidence can be systematically generated. In doing so, we characterised the ABR profiles of priority clinical pathogens, identified associated factors, and drew inferences on antibiotic usage in Uganda. Results: Of the 12…
Imported malaria predominates in near-elimination settings in Southwestern Uganda
Malaria transmission in southwestern Uganda is low, but persists despite control efforts. Identifying whether infections are locally sustained or imported by travelers is critical for guiding interventions. We integrated epidemiologic surveillance with parasite genomics to characterize imported malaria episodes at three health facilities in southwestern Uganda. Between January 2023 and June 2024, we enrolled microscopy-confirmed malaria cases at …
Optimizing hepatitis B diagnosis for mothers in a low-resource setting
Mother-to-child transmission accounts for most new hepatitis B (HBV) infections in high-burden regions globally. The World Health Organization recommends antiviral prophylaxis for pregnant women with high hepatitis B viral load levels, but access to viral load testing remains limited and untimely in many countries, due to centralized testing. We assessed the operational feasibility, accessibility, and cost of implementing the Xpert HBV DNA assay …
Wastewater-based surveillance as a proactive public health tool
Wastewater-based surveillance offers a cost-effective, population-level complement to clinical testing for early detection of infectious disease outbreaks; however, its adoption in low- and middle-income countries remains limited. We conducted a study in Kampala, Uganda, to quantify SARS-CoV-2 RNA in wastewater and evaluate its association with reported clinical cases, thereby strengthening community-level surveillance strategies. From March 2023…
Medicine (3 obras) · Biology (2 obras) · Concordance (2 obras) · Environmental health (2 obras) · Internal Medicine (2 obras) · Malaria (2 obras) · Mosquito-borne diseases and control (2 obras) · Pandemic (2 obras) · SARS-CoV-2 detection and testing (2 obras) · Transmission (telecommunications) (2 obras)