Dirk H Hellhammer

Datos Biográficos

ID7128610
NOMBREDirk H Hellhammer
NOMBRESDirk H
APELLIDOHellhammer
FIRMAHELLHAMMER D H
AFILIACIONESUniversität Trier
ORCID0000-0001-9262-6681
VERIFICADOSí
TOTAL DE OBRAS29
TOTAL DE CITAS0
TOTAL COMO AUTOR29
TOTAL COMO EDITOR0
PRIMER AÑO DE PUBLICACIÓN1983
AÑO MÁS RECIENTE DE PUBLICACIÓN2016
ÍNDICE H0

  • Assessment of the cortisol awakening response

    Open AccessTobias Stalder, Clemens Kirschbaum et al.ARTICLEPsychoneuroendocrinology2016

    The cortisol awakening response (CAR), the marked increase in cortisol secretion over the first 30-45 min after morning awakening, has been related to a wide range of psychosocial, physical and mental health parameters, making it a key variable for psychoneuroendocrinological research. The CAR is typically assessed from self-collection of saliva samples within the domestic setting. While this confers ecological validity, it lacks direct researche…

  • Salivary Cortisol in Ambulatory Assessment—Some Dos, Some Don’ts, and Some Open Questions

    Brigitte M Kudielka, Andrea Gierens et al.ARTICLEPsychosomatic Medicine2012

    The impact of stress on health and disease is an important research topic in psychosomatic medicine. Because research on hypothalamic-pituitary-adrenal (HPA) axis regulation under controlled laboratory studies lacks ecological validity, it needs to be complemented by a research program that includes momentary ambulatory assessment. The measurement of salivary cortisol offers the possibility to trace the free steroid hormone concentrations in ambu…

  • Salivary cortisol as a biomarker in stress research

    Open AccessDirk H Hellhammer, Stefan Wüst et al.ARTICLEPsychoneuroendocrinology2009

  • Salivary Cortisol in Psychobiological Research

    Open AccessClemens Kirschbaum, Dirk H HellhammerARTICLENeuropsychobiology2008

    The measurement of cortisol in saliva provides the basic scientist as well as the clinician with a reliable tool for investigations of hypothalamus-pituitary-adrenal axis activity. Since saliva samples can be obtained stress-free and independent from medically trained personnel this method may be well suited for use in psychobiological studies. This overview intends to give a comprehensive introduction to the method of salivary cortisol assessmen…

  • The ‘Trier Social Stress Test’ – A Tool for Investigating Psychobiological Stress Responses in a Laboratory Setting

    Open AccessClemens Kirschbaum, Karl-Martin Pirke et al.ARTICLENeuropsychobiology2008

    This paper describes a protocol for induction of moderate psychological stress in a laboratory setting and evaluates its effects on physiological responses. The ‘Trier Social Stress Test’ (TSST) mainly consists of an anticipation period (10 min) and a test period (10 min) in which the subjects have to deliver a free speech and perform mental arithmetic in front of an audience. In six independent studies this protocol has been found to induce cons…

  • HPA Axis Reactivity and Lymphocyte Glucocorticoid Sensitivity in Fibromyalgia Syndrome and Chronic Pelvic Pain

    Katja Wingenfeld, Christine Heim et al.ARTICLEPsychosomatic Medicine2008

    Objective: Chronic pelvic pain (CPP) and fibromyalgia syndrome (FMS) have been associated with hypothalamic-pituitary-adrenal (HPA) axis alterations, i.e., mild hypocortisolism and enhanced feedback sensitivity. We tested the hypothesis of reduced cortisol release in response to a psychosocial stressor and pharmacological stimulation. Furthermore, glucocorticoid (GC) sensitivity was evaluated. Methods: Plasma total and salivary-free cortisol conc…

  • A new view on hypocortisolism

    Open AccessEva Fries, Judith Hesse et al.ARTICLEPsychoneuroendocrinology2005

  • Basal and Stimulated Hypothalamic-Pituitary-Adrenal Axis Activity in Patients With Functional Gastrointestinal Disorders and Healthy Controls

    Andreas H Böhmelt, Urs M Nater et al.ARTICLEPsychosomatic Medicine2005

    Objective: The aim of this study was to investigate alterations of pituitary-adrenal activity under both stimulated and unstimulated conditions in patients with functional gastrointestinal disorders. Methods: Thirty subjects who fulfilled the Rome Diagnostic Criteria for either irritable bowel syndrome or nonulcer dyspepsia and 24 healthy controls took part in the study. Free salivary morning cortisol and diurnal cortisol profiles were obtained f…

  • Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change

    Open AccessJens C Pruessner, Jens Pruessner et al.ARTICLEPsychoneuroendocrinology2003

  • Self-Reported Depressive Symptoms and Stress Levels in Healthy Young Men

    Marita Pruessner, Dirk H Hellhammer et al.ARTICLEPsychosomatic Medicine2003

    OBJECTIVE: There is evidence that clinical depression and negative mood are associated with elevated basal cortisol levels. Recently, measuring the cortisol response during the first hour in the morning with strict reference to the time of awakening was established as a reliable marker of individual adrenocortical activity. In studies using this marker, a relationship with self-reported stress levels and psychosomatic symptoms has been found. The…

  • Dissociation Between Reactivity of the Hypothalamus-Pituitary-Adrenal Axis and the Sympathetic-Adrenal-Medullary System to Repeated Psychosocial Stress

    Patrice Sawicki, Nicole C Schommer et al.ARTICLEPsychosomatic Medicine2003

    From these data we conclude that habituation to psychosocial stress seems to be specific for a given response system. Although HPA responses quickly habituate, the sympathetic nervous system shows rather uniform activation patterns with repeated exposure to psychosocial challenge

  • Blunted Cortisol Responses to Psychosocial Stress in Asthmatic Children

    Angelika Buske-Kirschbaum, Kristin von Auer et al.ARTICLEPsychosomatic Medicine2003

    OBJECTIVE: Atopy is defined by the individual predisposition to develop a group of inflammatory disorders in response to certain food or environmental substances that are otherwise innocuous for the host. In previous studies we could demonstrate a reduced responsiveness of the hypothalamus-pituitary-adrenal (HPA) axis to psychosocial stress in young and adult patients with atopic dermatitis (AD), a chronic atopic skin disorder. With respect to th…

  • Sex Differences in Glucocorticoid Sensitivity of Proinflammatory Cytokine Production After Psychosocial Stress

    Nicolas Rohleder, Nicole C Schommer et al.ARTICLEPsychosomatic Medicine2001

    OBJECTIVE: Men and women show marked differences in susceptibility to disorders related to the immune system. These gender differences have been proposed to be mediated by functional interactions of the hypothalamus-pituitary-adrenal (HPA) and hypothalamus-pituitary-gonadal (HPG) axes. A potential mechanism involved in this interaction is the glucocorticoid (GC) sensitivity of relevant target tissues for GC. Therefore, the aim of the study report…

  • The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders

    Open AccessChristine Heim, Ulrike Ehlert et al.ARTICLEPsychoneuroendocrinology2000

  • Impact of Gender, Menstrual Cycle Phase, and Oral Contraceptives on the Activity of the Hypothalamus-Pituitary-Adrenal Axis

    Clemens Kirschbaum, Brigitte M Kudielka et al.ARTICLEPsychosomatic Medicine1999

    OBJECTIVE: Results from animal and human studies suggest that disregulations of the hypothalamus-pituitary-adrenal (HPA) axis are involved in several behavioral, circulatory, endocrine, and immune disorders with clear-cut gender differences in disease prevalence. The aim of the present study was to investigate sex-specific HPA response patterns with a focus on the contribution of gonadal steroids as possible mediators. METHODS: A total of 81 heal…

  • Burnout, Perceived Stress, and Cortisol Responses to Awakening

    Jens C Pruessner, Jens Pruessner et al.ARTICLEPsychosomatic Medicine1999

    OBJECTIVE: The effects of burnout and perceived stress on early morning free cortisol levels after awakening were investigated in a group of teachers. Previous studies revealed that cortisol levels show a significant increase after awakening, with high intraindividual stability. METHODS: Sixty-six teachers from local public schools (42 women and 24 men, mean age 42+/-5 years) were asked to sample saliva for cortisol analysis on 3 consecutive days…

  • No Evidence for a Close Relationship between Personality Traits and Circadian Cortisol Rhythm or a Single Cortisol Stress Response

    Open AccessNC Schommer, N C Schommer et al.ARTICLEPsychological Reports1999

    Personality traits measured with the Eysenck Personality Questionnaire-Revised did not show associations with basal or stimulated concentrations of cortisol in a sample of 81 subjects. Cortisol responses to a single exposure to psychosocial stress as well as circadian salivary-free cortisol patterns did not distinguish between subjects with high or low scores on Extraversion, Neuroticism, or Psychoticism, respectively

  • Stressors and Mood Measured on a Momentary Basis Are Associated With Salivary Cortisol Secretion

    Open AccessJoshua M Smyth, Joshua Smyth et al.ARTICLEPsychoneuroendocrinology1998

  • Abuse-Related Posttraumatic Stress Disorder and Alterations of the Hypothalamic-Pituitary-Adrenal Axis in Women With Chronic Pelvic Pain

    Christine Heim, Ulrike Ehlert et al.ARTICLEPsychosomatic Medicine1998

    OBJECTIVE: Although numerous organic conditions may cause chronic pelvic pain (CPP), diagnostic laparoscopy reveals a normal pelvis in many patients with CPP. However, psychological studies yield a high frequency of psychopathology and increased prevalences of chronic stress and traumatic life events, ie, sexual and physical abuse, in women with CPP, suggesting a relationship between posttraumatic stress disorder (PTSD) and CPP. As chronic stress…

  • Free Cortisol Levels after Awakening

    Open AccessJens Pruessner, J C Pruessner et al.ARTICLELife Sciences1997

  • Attenuated Free Cortisol Response to Psychosocial Stress in Children with Atopic Dermatitis

    Angelika Buske-Kirschbaum, Silke Jobst et al.ARTICLEPsychosomatic Medicine1997

    OBJECTIVE: Atopic dermatitis (AD) is an inflammatory skin disease characterized by a hyperactivity of the humoral immune system with an onset in infancy or early childhood. Although most of the research has focused on the pathophysiological role of the immune system in AD, the impact of endocrine signals in the pathology of AD has received only little attention. However, because the endocrine system may play a regulatory role in immune functionin…

  • Persistent High Cortisol Responses to Repeated Psychological Stress in a Subpopulation of Healthy Men

    Clemens Kirschbaum, Jens C Prussner et al.ARTICLEPsychosomatic Medicine1995

    The present study tested the hypothesis that some subjects may not readily show habituation of adrenocortical stress responses to repeated psychological stress. Twenty healthy male subjects were each exposed five times to the same, brief psychosocial stressor (public speaking and mental arithmetic in front of an audience) with one stress session per day. Salivary cortisol levels were assessed as an index of adrenocortical stress responses. For th…

  • Sex-Specific Effects of Social Support on Cortisol and Subjective Responses to Acute Psychological Stress

    Clemens Kirschbaum, Thomas Klauer et al.ARTICLEPsychosomatic Medicine1995

    The effects of short-term social support on cortisol levels and subjective responses to acute psychological stress were investigated in healthy adults (total N = 66). In anticipation of a public-speaking task in front of an audience, subjects received either no social support ("no support") or social support from an opposite-sex stranger ("stranger") or from their boyfriend or girlfriend ("partner"). Support providers were instructed to enact bot…

  • Effect of Chronic Stress Associated With Unemployment on Salivary Cortisol

    Margit C Ockenfels, Laura S Porter et al.ARTICLEPsychosomatic Medicine1995

    This study examined the effect of chronic stress associated with unemployment on the magnitude of salivary cortisol excretion, on the diurnal rhythm of cortisol, and on cortisol reactivity to acute naturalistic stressors using Experience Sampling Methodology (ESM). Employed (N = 60) and unemployed (N = 60) subjects were studied for 2 days. Subjects were beeped 6 times per day by a preprogrammed wristwatch to assess acute stressors; 25 minutes aft…

  • Salivary cortisol in psychoneuroendocrine research

    Open AccessClemens Kirschbaum, Dirk H HellhammerARTICLEPsychoneuroendocrinology1994