Gustavo Turecki
Datos Biográficos
| ID | 7370536 |
|---|---|
| NOMBRE | Gustavo Turecki |
| NOMBRES | Gustavo |
| APELLIDO | Turecki |
| FIRMA | TURECKI G |
| AFILIACIONES | Douglas Mental Health University Institute |
| ORCID | 0000-0003-4075-2736 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 24 |
| TOTAL DE CITAS | 0 |
| TOTAL COMO AUTOR | 24 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 2004 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2023 |
| ÍNDICE H | 0 |
Polygenic risk score and peer victimisation independently predict depressive symptoms in adolescence
BACKGROUND: Peer victimisation has been associated with depressive symptoms during adolescence, however not all peer victimised adolescents will exhibit such symptoms. This study tested whether having a genetic predisposition to developing depression increased the risk of experiencing depressive symptoms in peer victimised youth. To date, no study has explored such gene-environment interaction using a polygenic risk score for depression (PRS-depr…
DNA Methylation Signatures of Functional Somatic Syndromes
The Montreal model
Our integrative model aims to bridge the biomedical-psychedelic divide to offer a feasible, flexible, and standardized approach to ketamine for TRD. Our learnings from developing and implementing this psychedelic-inspired model for severe, real-world patients in two academic hospitals may offer valuable insights for the ongoing roll-out of a range of psychedelic therapies. Further research is needed to assess the Montreal model's effectiveness an…
DNA methylation in cocaine use disorder–An epigenome-wide approach in the human prefrontal cortex
Results from our study highlight that CUD is associated with epigenome-wide differences in DNAm levels in BA9 particularly related to synaptic signaling and neuroplasticity. This supports findings from previous studies that report on the strong impact of cocaine on neurocircuits in the human prefrontal cortex (PFC). Further studies are needed to follow up on the role of epigenetic alterations in CUD focusing on the integration of epigenetic signa…
Common Data Elements to Facilitate Sharing and Re-use of Participant-Level Data
The Ontario Brain Institute's "Brain-CODE" is a large-scale informatics platform designed to support the collection, storage and integration of diverse types of data across several brain disorders as a means to understand underlying causes of brain dysfunction and developing novel approaches to treatment. By providing access to aggregated datasets on participants with and without different brain disorders, Brain-CODE will facilitate analyses both…
Identifying environmental pathways between irritability during childhood and suicidal ideation and attempt in adolescence
BACKGROUND: Irritable children are at increased risk of suicidal ideation and suicide attempt, but the underlying environmental mechanisms accounting for these associations are largely unknown. We aimed to investigate the mediating role of peer victimization and harsh parenting in the association between childhood irritability and adolescent suicidal ideation and attempt. METHOD: N = 1,483 participants from the Québec Longitudinal Study of Child …
Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood
BACKGROUND: Children who consistently withdraw from social situations face increased risk for later socioemotional difficulties. Twin studies indicate that genetic factors substantially account for the persistence of social withdrawal over time. However, the molecular genetic etiology of chronic courses of social wariness and preference for solitude, two dimensions of social withdrawal, remains undocumented. The objectives of the present study we…
Effects of Mindfulness-Based Cognitive Therapy on Peripheral Markers of Stress and Inflammation in Older-Adults With Depression and Anxiety
Background: Depression and anxiety are prevalent in older-adults and often difficult to treat: up to 55% of patients are unresponsive to pharmacotherapy. Mindfulness-Based Cognitive Therapy (MBCT) is a promising treatment, however, its biological mechanisms remain unknown in older-adults. Methods: We examined if, in older-adults, decreased depression and anxiety symptoms after MBCT are associated with changes in the expression levels of C-reactiv…
Widespread Decrease of Cerebral Vimentin-Immunoreactive Astrocytes in Depressed Suicides
Post-mortem investigations have implicated cerebral astrocytes immunoreactive (-IR) for glial fibrillary acidic protein (GFAP) in the etiopathology of depression and suicide. However, it remains unclear whether astrocytic subpopulations IR for other astrocytic markers are similarly affected. Astrocytes IR to vimentin (VIM) display different regional densities than GFAP-IR astrocytes in the healthy brain, and so may be differently altered in depre…
Association of Social Support During Adolescence With Depression, Anxiety, and Suicidal Ideation in Young Adults
Importance: Mental health problems are common during the transition from adolescence to young adulthood. Although perceived social support and mental health problems have been shown to be concurrently associated, longitudinal studies are lacking to document the directionality of this association, especially in emerging adulthood (late teens to late 20s). Objective: To test whether social support in emerging adulthood protects against later depres…
Suicide risk and prevention during the Covid-19 pandemic
Cybervictimization in adolescence and its association with subsequent suicidal ideation/attempt beyond face‐to‐face victimization
BACKGROUND: Cross-sectional associations have been documented between cybervictimization and suicidal risk; however, prospective associations remain unclear. METHODS: Participants were members of the Quebec Longitudinal Study of Child Development (QLSCD), a prospective birth cohort of 2,120 individuals followed from birth (1997/98) to age 17 years (2014/15). Cybervictimization and face-to-face victimization experienced since the beginning of the …
Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major Depression
Major depressive disorder (MDD) is a heterogeneous disorder. Our hypothesis is that neurological symptoms correlate with the severity of MDD symptoms. One hundred eighty-four outpatients with MDD completed a self-report questionnaire on past and present medical history. Patients were divided into three roughly equal depression severity levels based on scores from the APA Severity Measure for Depression-Adult ( n = 66, 58, 60, for low, medium, hig…
Suicide amongst the Inuit of Nunavut
This article reports results of the life trajectories from 92 Inuit who died by suicide, matched for age and gender with 92 living-controls. A proxy-based procedure and semi-structured interviews with informants were conducted to obtain trajectories of developmental events occurring over the life course for suicide and community-matched controls. Results from this research indicate two different trajectories that differentiate the control-group f…
Suicide and suicide risk
Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder
Bipolar disorder (BD) is a common, highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. Lithium is the best-established long-term treatment for BD, even though individual response is highly variable. Evidence suggests that some of this variability has a genetic basis. This is supported by the largest genome-wide association study (GWAS) of lithium response to date conducted by the International Co…
Protective Factors in the Inuit Population of Nunavut
Epidemiological data shows an alarming prevalence of suicide in Aboriginal populations around the world. In Canada, the highest rates are found in Inuit communities. In this article, we present the findings of a secondary analysis conducted with data previously collected as part of a larger study of psychological autopsies conducted in Nunavut, Canada. The objective of this secondary analysis was to identify protective factors in the Inuit popula…
Suicide and suicidal behaviour
Cellular and Molecular Inflammatory Profile of the Choroid Plexus in Depression and Suicide
The inflammatory hypothesis of depression is one of the main theories that endeavors to explain and describe the underlying biological mechanisms of depression and suicide. While mounting evidence indicates altered peripheral and central inflammatory profiles in depressed patients and suicide completers, little is known about how peripheral and central inflammation might be linked in these contexts. The choroid plexus (ChP), a highly vascularized…
Épigénétique
L’adversité au cours du jeune âge est connue pour augmenter le risque de développer des problèmes de santé mentale à l’âge adulte. Récemment, des mécanismes épigénétiques ont été identifiés comme représentant une interface sur laquelle l’environnement agit pour induire des changements comportementaux. Ces changements, qui affectent l’expression de certains gènes, sans modifier la séquence d’ADN, interfèrent avec le fonctionnement des systèmes rég…
Dialogue transdisciplinaire sur l’étiologie et la prévention du suicide au Québec
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
Self-Critical Perfectionism Is Associated With Increases in Sympathetic Indicators in a Controlled Laboratory Stress Paradigm
McGill Group for Suicide Studies; Douglas Mental Health University Institute; McGill University; Montreal, Quebec, Canada; Faculty of Medicine; University of Toronto; Toronto, Ontario, Canada; E-mail: [email protected] (McGirr) McGill Group for Suicide Studies; Douglas Mental Health University Institute; McGill University; Montreal, Quebec, Canada (Turecki)
Psychiatric diagnoses in 3275 suicides
Sin obras prominentes en esta página.
Psychiatric diagnoses in 3275 suicides
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
Self-Critical Perfectionism Is Associated With Increases in Sympathetic Indicators in a Controlled Laboratory Stress Paradigm
McGill Group for Suicide Studies; Douglas Mental Health University Institute; McGill University; Montreal, Quebec, Canada; Faculty of Medicine; University of Toronto; Toronto, Ontario, Canada; E-mail: [email protected] (McGirr) McGill Group for Suicide Studies; Douglas Mental Health University Institute; McGill University; Montreal, Quebec, Canada (Turecki)
Dialogue transdisciplinaire sur l’étiologie et la prévention du suicide au Québec
Épigénétique
L’adversité au cours du jeune âge est connue pour augmenter le risque de développer des problèmes de santé mentale à l’âge adulte. Récemment, des mécanismes épigénétiques ont été identifiés comme représentant une interface sur laquelle l’environnement agit pour induire des changements comportementaux. Ces changements, qui affectent l’expression de certains gènes, sans modifier la séquence d’ADN, interfèrent avec le fonctionnement des systèmes rég…
Cellular and Molecular Inflammatory Profile of the Choroid Plexus in Depression and Suicide
The inflammatory hypothesis of depression is one of the main theories that endeavors to explain and describe the underlying biological mechanisms of depression and suicide. While mounting evidence indicates altered peripheral and central inflammatory profiles in depressed patients and suicide completers, little is known about how peripheral and central inflammation might be linked in these contexts. The choroid plexus (ChP), a highly vascularized…
Suicide and suicidal behaviour
Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder
Bipolar disorder (BD) is a common, highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. Lithium is the best-established long-term treatment for BD, even though individual response is highly variable. Evidence suggests that some of this variability has a genetic basis. This is supported by the largest genome-wide association study (GWAS) of lithium response to date conducted by the International Co…
Protective Factors in the Inuit Population of Nunavut
Epidemiological data shows an alarming prevalence of suicide in Aboriginal populations around the world. In Canada, the highest rates are found in Inuit communities. In this article, we present the findings of a secondary analysis conducted with data previously collected as part of a larger study of psychological autopsies conducted in Nunavut, Canada. The objective of this secondary analysis was to identify protective factors in the Inuit popula…
Suicide and suicide risk
Association of Social Support During Adolescence With Depression, Anxiety, and Suicidal Ideation in Young Adults
Importance: Mental health problems are common during the transition from adolescence to young adulthood. Although perceived social support and mental health problems have been shown to be concurrently associated, longitudinal studies are lacking to document the directionality of this association, especially in emerging adulthood (late teens to late 20s). Objective: To test whether social support in emerging adulthood protects against later depres…
Suicide risk and prevention during the Covid-19 pandemic
Cybervictimization in adolescence and its association with subsequent suicidal ideation/attempt beyond face‐to‐face victimization
BACKGROUND: Cross-sectional associations have been documented between cybervictimization and suicidal risk; however, prospective associations remain unclear. METHODS: Participants were members of the Quebec Longitudinal Study of Child Development (QLSCD), a prospective birth cohort of 2,120 individuals followed from birth (1997/98) to age 17 years (2014/15). Cybervictimization and face-to-face victimization experienced since the beginning of the …
Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major Depression
Major depressive disorder (MDD) is a heterogeneous disorder. Our hypothesis is that neurological symptoms correlate with the severity of MDD symptoms. One hundred eighty-four outpatients with MDD completed a self-report questionnaire on past and present medical history. Patients were divided into three roughly equal depression severity levels based on scores from the APA Severity Measure for Depression-Adult ( n = 66, 58, 60, for low, medium, hig…
Suicide amongst the Inuit of Nunavut
This article reports results of the life trajectories from 92 Inuit who died by suicide, matched for age and gender with 92 living-controls. A proxy-based procedure and semi-structured interviews with informants were conducted to obtain trajectories of developmental events occurring over the life course for suicide and community-matched controls. Results from this research indicate two different trajectories that differentiate the control-group f…
Identifying environmental pathways between irritability during childhood and suicidal ideation and attempt in adolescence
BACKGROUND: Irritable children are at increased risk of suicidal ideation and suicide attempt, but the underlying environmental mechanisms accounting for these associations are largely unknown. We aimed to investigate the mediating role of peer victimization and harsh parenting in the association between childhood irritability and adolescent suicidal ideation and attempt. METHOD: N = 1,483 participants from the Québec Longitudinal Study of Child …
Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood
BACKGROUND: Children who consistently withdraw from social situations face increased risk for later socioemotional difficulties. Twin studies indicate that genetic factors substantially account for the persistence of social withdrawal over time. However, the molecular genetic etiology of chronic courses of social wariness and preference for solitude, two dimensions of social withdrawal, remains undocumented. The objectives of the present study we…
Effects of Mindfulness-Based Cognitive Therapy on Peripheral Markers of Stress and Inflammation in Older-Adults With Depression and Anxiety
Background: Depression and anxiety are prevalent in older-adults and often difficult to treat: up to 55% of patients are unresponsive to pharmacotherapy. Mindfulness-Based Cognitive Therapy (MBCT) is a promising treatment, however, its biological mechanisms remain unknown in older-adults. Methods: We examined if, in older-adults, decreased depression and anxiety symptoms after MBCT are associated with changes in the expression levels of C-reactiv…
Widespread Decrease of Cerebral Vimentin-Immunoreactive Astrocytes in Depressed Suicides
Post-mortem investigations have implicated cerebral astrocytes immunoreactive (-IR) for glial fibrillary acidic protein (GFAP) in the etiopathology of depression and suicide. However, it remains unclear whether astrocytic subpopulations IR for other astrocytic markers are similarly affected. Astrocytes IR to vimentin (VIM) display different regional densities than GFAP-IR astrocytes in the healthy brain, and so may be differently altered in depre…
Common Data Elements to Facilitate Sharing and Re-use of Participant-Level Data
The Ontario Brain Institute's "Brain-CODE" is a large-scale informatics platform designed to support the collection, storage and integration of diverse types of data across several brain disorders as a means to understand underlying causes of brain dysfunction and developing novel approaches to treatment. By providing access to aggregated datasets on participants with and without different brain disorders, Brain-CODE will facilitate analyses both…
Polygenic risk score and peer victimisation independently predict depressive symptoms in adolescence
BACKGROUND: Peer victimisation has been associated with depressive symptoms during adolescence, however not all peer victimised adolescents will exhibit such symptoms. This study tested whether having a genetic predisposition to developing depression increased the risk of experiencing depressive symptoms in peer victimised youth. To date, no study has explored such gene-environment interaction using a polygenic risk score for depression (PRS-depr…
DNA Methylation Signatures of Functional Somatic Syndromes
The Montreal model
Our integrative model aims to bridge the biomedical-psychedelic divide to offer a feasible, flexible, and standardized approach to ketamine for TRD. Our learnings from developing and implementing this psychedelic-inspired model for severe, real-world patients in two academic hospitals may offer valuable insights for the ongoing roll-out of a range of psychedelic therapies. Further research is needed to assess the Montreal model's effectiveness an…
DNA methylation in cocaine use disorder–An epigenome-wide approach in the human prefrontal cortex
Results from our study highlight that CUD is associated with epigenome-wide differences in DNAm levels in BA9 particularly related to synaptic signaling and neuroplasticity. This supports findings from previous studies that report on the strong impact of cocaine on neurocircuits in the human prefrontal cortex (PFC). Further studies are needed to follow up on the role of epigenetic alterations in CUD focusing on the integration of epigenetic signa…
Medicine (18 obras) · Psychology (17 obras) · Psychiatry (14 obras) · Poison control (10 obras) · Suicide prevention (10 obras) · Clinical Psychology (9 obras) · Medical emergency (7 obras) · Suicide and Self-Harm Studies (7 obras) · Biology (6 obras) · Child and Adolescent Psychosocial and Emotional Development (6 obras)