Patrick R Hof
Datos Biográficos
| ID | 75357 |
|---|---|
| NOMBRE | Patrick R Hof |
| NOMBRES | Patrick R |
| APELLIDO | Hof |
| FIRMA | HOF P R |
| AFILIACIONES | Icahn School of Medicine at Mount Sinai |
| ORCID | 0000-0002-3208-1154 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 13 |
| TOTAL DE CITAS | 17 |
| TOTAL COMO AUTOR | 13 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 2004 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2023 |
| ÍNDICE H | 3 |
Stress-related reduction of hippocampal subfield volumes in major depressive disorder
Determining biomarkers for MDD and TRD pathophysiology through segmentation on high-resolution MRI data and understanding the effects of stress on these regions can enable better assessment of biological response to treatment selection and may elucidate the underlying mechanisms of depression
Comparative neuropathology in aging primates
While humans exhibit a significant degree of neuropathological changes associated with deficits in cognitive and memory functions during aging, non‐human primates (NHP) present with more variable expressions of pathological alterations among individuals and species. As such, NHP with long life expectancy in captivity offer an opportunity to study brain senescence in the absence of the typical cellular pathology caused by age‐related neurodegenera…
The marmoset as an important primate model for longitudinal studies of neurocognitive aging
Age‐related cognitive decline has been extensively studied in humans, but the majority of research designs are cross‐sectional and compare across younger and older adults. Longitudinal studies are necessary to capture variability in cognitive aging trajectories but are difficult to carry out in humans and long‐lived nonhuman primates. Marmosets are an ideal primate model for neurocognitive aging as their naturally short lifespan facilitates longi…
Brain organization of gorillas reflects species differences in ecology
Gorillas include separate eastern ( Gorilla beringei ) and western ( Gorilla gorilla ) African species that diverged from each other approximately 2 million years ago. Although anatomical, genetic, behavioral, and socioecological differences have been noted among gorilla populations, little is known about variation in their brain structure. This study examines neuroanatomical variation between gorilla species using structural neuroimaging. Postmo…
Metabolic costs and evolutionary implications of human brain development
Significance The metabolic costs of brain development are thought to explain the evolution of humans’ exceptionally slow and protracted childhood growth; however, the costs of the human brain during development are unknown. We used existing PET and MRI data to calculate brain glucose use from birth to adulthood. We find that the brain’s metabolic requirements peak in childhood, when it uses glucose at a rate equivalent to 66% of the body’s restin…
Characterization of human cortical gene expression in relation to glucose utilization
OBJECTIVES: Human brain development follows a unique pattern characterized by a prolonged period of postnatal growth and reorganization, and a postnatal peak in glucose utilization. The molecular processes underlying these developmental changes are poorly characterized. The objectives of this study were to determine developmental trajectories of gene expression and to examine the evolutionary history of genes differentially expressed as a functio…
Neuropeptide Y ‐immunoreactive Neurons in the Cerebral Cortex of Humans and Other Haplorrhine Primates
We examined the distribution of neurons immunoreactive for neuropeptide Y ( NPY ) in the posterior part of the superior temporal cortex ( B rodmann's area 22 or area T pt) of humans and nonhuman haplorrhine primates. NPY has been implicated in learning and memory and the density of NPY ‐expressing cortical neurons and axons is reduced in depression, bipolar disorder, schizophrenia, and A lzheimer's disease. Due to the role that NPY plays in both …
Early Brain Growth Cessation in Wild Virunga Mountain Gorillas ( Gorilla beringei beringei )
Understanding the life history correlates of ontogenetic differences in hominoid brain growth requires information from multiple species. At present, however, data on how brain size changes over the course of development are only available from chimpanzees and modern humans. In this study, we examined brain growth in wild Virunga mountain gorillas using data derived from necropsy reports ( N = 34) and endocranial volume (EV) measurements ( N = 86…
A volumetric comparison of the insular cortex and its subregions in primates
Biochemical specificity of von economo neurons in hominoids
Objectives: Von Economo neurons (VENs) are defined by their thin, elongated cell body and long dendrites projecting from apical and basal ends. These distinctive neurons are mostly present in anterior cingulate (ACC) and fronto‐insular (FI) cortex, with particularly high densities in cetaceans, elephants, and hominoid primates (i.e., humans and apes). This distribution suggests that VENs contribute to specializations of neural circuits in species…
Hominoid visual brain structure volumes and the position of the lunate sulcus
Evolution of the brainstem orofacial motor system in primates
Brain structure variation in great apes, with attention to the mountain gorilla ( Gorilla beringei beringei )
This report presents data regarding the brain structure of mountain gorillas ( Gorilla beringei beringei ) in comparison with other great apes. Magnetic resonance (MR) images of three mountain gorilla brains were obtained with a 3T scanner, and the volume of major neuroanatomical structures (neocortical gray matter, hippocampus, thalamus, striatum, and cerebellum) was measured. These data were included with our existing database that includes 23 …
Hominoid visual brain structure volumes and the position of the lunate sulcus
Evolution of the brainstem orofacial motor system in primates
A volumetric comparison of the insular cortex and its subregions in primates
Brain organization of gorillas reflects species differences in ecology
Gorillas include separate eastern ( Gorilla beringei ) and western ( Gorilla gorilla ) African species that diverged from each other approximately 2 million years ago. Although anatomical, genetic, behavioral, and socioecological differences have been noted among gorilla populations, little is known about variation in their brain structure. This study examines neuroanatomical variation between gorilla species using structural neuroimaging. Postmo…
Brain structure variation in great apes, with attention to the mountain gorilla ( Gorilla beringei beringei )
This report presents data regarding the brain structure of mountain gorillas ( Gorilla beringei beringei ) in comparison with other great apes. Magnetic resonance (MR) images of three mountain gorilla brains were obtained with a 3T scanner, and the volume of major neuroanatomical structures (neocortical gray matter, hippocampus, thalamus, striatum, and cerebellum) was measured. These data were included with our existing database that includes 23 …
Evolution of the brainstem orofacial motor system in primates
Hominoid visual brain structure volumes and the position of the lunate sulcus
Biochemical specificity of von economo neurons in hominoids
Objectives: Von Economo neurons (VENs) are defined by their thin, elongated cell body and long dendrites projecting from apical and basal ends. These distinctive neurons are mostly present in anterior cingulate (ACC) and fronto‐insular (FI) cortex, with particularly high densities in cetaceans, elephants, and hominoid primates (i.e., humans and apes). This distribution suggests that VENs contribute to specializations of neural circuits in species…
Characterization of human cortical gene expression in relation to glucose utilization
OBJECTIVES: Human brain development follows a unique pattern characterized by a prolonged period of postnatal growth and reorganization, and a postnatal peak in glucose utilization. The molecular processes underlying these developmental changes are poorly characterized. The objectives of this study were to determine developmental trajectories of gene expression and to examine the evolutionary history of genes differentially expressed as a functio…
Neuropeptide Y ‐immunoreactive Neurons in the Cerebral Cortex of Humans and Other Haplorrhine Primates
We examined the distribution of neurons immunoreactive for neuropeptide Y ( NPY ) in the posterior part of the superior temporal cortex ( B rodmann's area 22 or area T pt) of humans and nonhuman haplorrhine primates. NPY has been implicated in learning and memory and the density of NPY ‐expressing cortical neurons and axons is reduced in depression, bipolar disorder, schizophrenia, and A lzheimer's disease. Due to the role that NPY plays in both …
Early Brain Growth Cessation in Wild Virunga Mountain Gorillas ( Gorilla beringei beringei )
Understanding the life history correlates of ontogenetic differences in hominoid brain growth requires information from multiple species. At present, however, data on how brain size changes over the course of development are only available from chimpanzees and modern humans. In this study, we examined brain growth in wild Virunga mountain gorillas using data derived from necropsy reports ( N = 34) and endocranial volume (EV) measurements ( N = 86…
A volumetric comparison of the insular cortex and its subregions in primates
Metabolic costs and evolutionary implications of human brain development
Significance The metabolic costs of brain development are thought to explain the evolution of humans’ exceptionally slow and protracted childhood growth; however, the costs of the human brain during development are unknown. We used existing PET and MRI data to calculate brain glucose use from birth to adulthood. We find that the brain’s metabolic requirements peak in childhood, when it uses glucose at a rate equivalent to 66% of the body’s restin…
Brain organization of gorillas reflects species differences in ecology
Gorillas include separate eastern ( Gorilla beringei ) and western ( Gorilla gorilla ) African species that diverged from each other approximately 2 million years ago. Although anatomical, genetic, behavioral, and socioecological differences have been noted among gorilla populations, little is known about variation in their brain structure. This study examines neuroanatomical variation between gorilla species using structural neuroimaging. Postmo…
Comparative neuropathology in aging primates
While humans exhibit a significant degree of neuropathological changes associated with deficits in cognitive and memory functions during aging, non‐human primates (NHP) present with more variable expressions of pathological alterations among individuals and species. As such, NHP with long life expectancy in captivity offer an opportunity to study brain senescence in the absence of the typical cellular pathology caused by age‐related neurodegenera…
The marmoset as an important primate model for longitudinal studies of neurocognitive aging
Age‐related cognitive decline has been extensively studied in humans, but the majority of research designs are cross‐sectional and compare across younger and older adults. Longitudinal studies are necessary to capture variability in cognitive aging trajectories but are difficult to carry out in humans and long‐lived nonhuman primates. Marmosets are an ideal primate model for neurocognitive aging as their naturally short lifespan facilitates longi…
Stress-related reduction of hippocampal subfield volumes in major depressive disorder
Determining biomarkers for MDD and TRD pathophysiology through segmentation on high-resolution MRI data and understanding the effects of stress on these regions can enable better assessment of biological response to treatment selection and may elucidate the underlying mechanisms of depression
Biology (12 obras) · Neuroscience (10 obras) · Medicine (8 obras) · Brain size (7 obras) · Primate (7 obras) · Primate Behavior and Ecology (7 obras) · Anatomy (4 obras) · Magnetic resonance imaging (4 obras) · Psychology (4 obras) · Anatomy (3 obras)