Hildegard Brenner
Datos Biográficos
| ID | 974089 |
|---|---|
| NOMBRE | Hildegard Brenner |
| NOMBRES | Hildegard |
| APELLIDO | Brenner |
| FIRMA | BRENNER H |
| AFILIACIONES | German Cancer Research Center |
| ORCID | 0000-0002-6129-1572 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 47 |
| TOTAL DE CITAS | 16 |
| TOTAL COMO AUTOR | 47 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 1975 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2026 |
| ÍNDICE H | 2 |
Participation behaviour of different migrant groups in breast cancer screening – palpation of the breast and mammography. Results from the German national cohort (Nako)
In contrast to earlier studies, our findings suggest that MSP participation and motivation does not significantly differ by migration status or language skills. This may indicate that information on MSP is broadly accessible through established invitation procedures in Germany. However, lower uptake of breast palpation by a physician in some migrant populations highlights potential gaps in broader preventive care engagement
Care delay during the Covid-19 pandemic in Germany – a cross-sectional online survey in the Nako study
During the COVID-19 pandemic, non-COVID-19 related healthcare utilization declined in Germany, resulting in care delay, including delays and cancellations of routine, chronic, and even acute care. The aim of this study was to investigate factors (i.e. regional differences and participant characteristics) associated with care delay during the pandemic in Germany using a cross-sectional survey. In October 2022, a total of 117,466 participants from …
Depression and anxiety symptoms in internally migrated women and men after the German unification
Subgroup analyses revealed group differences to depend on sex, but show negligible effect sizes, with internal migration only explaining less than 0.2 % of the variance for depression and anxiety symptoms. Internal migration alone is thus no substantial factor in explaining mental health differences. Future studies should use longitudinal data to determine temporal associations between internal migration and mental health
Piloting a cancer awareness app across six European countries
Background Cancer remains a significant public health challenge in Europe, accounting for over 22% of global cancer cases. Mobile health applications may help to increase the awareness of cancer risks and preventive behaviors. However, usability barriers and disparities in digital health literacy (DHL) may limit their impact. Objective This study evaluated the usability of the EU Mobile App for Cancer Prevention and changes in cancer awareness as…
What can we learn from an intersectionality-informed description of study participants? Results from the German National Cohort
Our results showed that heterogeneity within social categories can be revealed by applying the concept of intersectionality when comparing study participants with an external population. This way, an intersectionality-informed approach contributes to describing social complexity among study participants more precisely. Furthermore, results can be used to reduce participation barriers in a more targeted way
Depressive symptoms, education, gender and history of migration - an intersectional analysis using data from the German National Cohort (Nako)
We observed a robust educational gradient in depressive symptoms, but gender and history of migration had substantial contribution on the magnitude of educational inequalities. An intersectional perspective on inequalities in depressive symptoms enhances current knowledge by showing that different social dimensions may intersect and contribute to inequalities in depressive symptoms. Future studies on inequalities in depression may greatly benefit…
From cigarettes to symptoms
Our findings support an association between smoking and depression. Robust dose-response relationships were found, with higher cigarette consumption associated with more severe depressive symptoms, and longer time since cessation linked to lower depression levels. These results highlight smoking as a meaningful and modifiable contributor to current and lifetime depression, suggesting that quitting smoking or reducing cigarette consumption may ben…
The experience of social loss and epigenome-wide DNA methylation
BACKGROUND: Social loss is associated with mental and physical health problems. Considering known risk and resilience factors, we hypothesized that epigenome-wide DNA methylation (DNAm) would be associated with social loss. METHODS: A total of N = 1865 participants aged 50-75 years with epigenome-wide DNAm measurements obtained from whole blood samples were included. Using cross-sectional data, relationship status (married/divorced/widowed) was e…
Global, regional, and national burden of disorders affecting the nervous system, 1990–2021
BACKGROUND: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by…
Changes in physical activity and sedentary behavior during the first Covid-19 pandemic- restrictions in Germany
Mobility patterns shifted towards inactivity or low-intensity activities during the nationwide restrictions in the spring of 2020, potentially leading to considerable and lasting health risks
The state of health in the European Union (EU-27) in 2019
There was a clear trend towards improvement in the overall health status of the EU but with differences between countries. EU health policymakers need to address the burden of diseases, paying specific attention to causes such as mental disorders. There are many opportunities for mutual learning among otherwise similar countries with different patterns of disease
Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050
BACKGROUND: Given the projected trends in population ageing and population growth, the number of people with dementia is expected to increase. In addition, strong evidence has emerged supporting the importance of potentially modifiable risk factors for dementia. Characterising the distribution and magnitude of anticipated growth is crucial for public health planning and resource prioritisation. This study aimed to improve on previous forecasts of…
Population-level risks of alcohol consumption by amount, geography, age, sex, and year
BACKGROUND: The health risks associated with moderate alcohol consumption continue to be debated. Small amounts of alcohol might lower the risk of some health outcomes but increase the risk of others, suggesting that the overall risk depends, in part, on background disease rates, which vary by region, age, sex, and year. METHODS: For this analysis, we constructed burden-weighted dose-response relative risk curves across 22 health outcomes to esti…
Birth Order, Caesarean Section, or Daycare Attendance in Relation to Child- and Adult-Onset Type 1 Diabetes
(1) Background: Global incidence of type 1 diabetes (T1D) is rising and nearly half occurred in adults. However, it is unclear if certain early-life childhood T1D risk factors were also associated with adult-onset T1D. This study aimed to assess associations between birth order, delivery mode or daycare attendance and type 1 diabetes (T1D) risk in a population-based cohort and whether these were similar for childhood- and adult-onset T1D (cut-off…
Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019
BACKGROUND: Ending the global tobacco epidemic is a defining challenge in global health. Timely and comprehensive estimates of the prevalence of smoking tobacco use and attributable disease burden are needed to guide tobacco control efforts nationally and globally. METHODS: We estimated the prevalence of smoking tobacco use and attributable disease burden for 204 countries and territories, by age and sex, from 1990 to 2019 as part of the Global B…
Global, regional, and national burden of stroke and its risk factors, 1990–2019
BACKGROUND: Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national leve…
Loneliness as a gender-specific predictor of physical and mental health-related quality of life in older adults
HRQOL in elderly women and men is predicted by different biopsychosocial factors. Loneliness predicts decreased MCS after three years in both genders, but decreased PCS after three years only in women. Thus, a greater impact of loneliness on the health of older women can be surmised and should therefore be considered in the context of their medical care
Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019
Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consisten…
Advancing the evidence base for public policies impacting on dietary behaviour, physical activity and sedentary behaviour in Europe
28 research institutes have joined in the Policy Evaluation Network (PEN). • PEN studies EU policies on diet, physical activity and sedentary behaviours. • PEN advances knowledge on impact and effective implementation of these policies. • We here describe the rationale and specific goals of PEN, and highlight innovations. Non-communicable diseases (NCDs) are the leading cause of global mortality. As the social and economic costs of NCDs have esca…
World Health Organization cardiovascular disease risk charts
BACKGROUND: To help adapt cardiovascular disease risk prediction approaches to low-income and middle-income countries, WHO has convened an effort to develop, evaluate, and illustrate revised risk models. Here, we report the derivation, validation, and illustration of the revised WHO cardiovascular disease risk prediction charts that have been adapted to the circumstances of 21 global regions. METHODS: In this model revision initiative, we derived…
Alcohol use and burden for 195 countries and territories, 1990–2016
BACKGROUND: Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions. With our comprehensive approach to health accounting within the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we generated improved estimates of alcohol use and alcohol-attributable deaths and disability-adjus…
Screen Time, Physical Activity and Self-Esteem in Children
Screen time is a central activity of children’s daily life and jeopardizes mental health. However, results appear inconclusive and are often based on small cross-sectional studies. We aimed to investigate the temporal sequence of the association between screen time and self-esteem taking into account further indirect effects through family or friendship relationship. In our population-based birth cohort study (baseline November 2000−November 2001…
Smoking prevalence and attributable disease burden in 195 countries and territories, 1990–2015
BACKGROUND: The scale-up of tobacco control, especially after the adoption of the Framework Convention for Tobacco Control, is a major public health success story. Nonetheless, smoking remains a leading risk for early death and disability worldwide, and therefore continues to require sustained political commitment. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) offers a robust platform through which global, regional, and na…
Die Kunstpolitik des Nationalsozialismus
Strukturalismus als interpretatives Verfahren
A birth cohort analysis of the smoking epidemic in West Germany
STUDY OBJECTIVE--The aim was to provide insights in the spread of the smoking epidemic and eventual progress against cigarette smoking in West Germany. DESIGN--This was a retrospective birth cohort analysis based on a cross sectional national survey. SETTING--The survey was conducted in 1987 by the Ministry of Youth, Family and Health in order to identify priorities for health policy and promotion. The target population were all residents of Germ…
Advancing the evidence base for public policies impacting on dietary behaviour, physical activity and sedentary behaviour in Europe
28 research institutes have joined in the Policy Evaluation Network (PEN). • PEN studies EU policies on diet, physical activity and sedentary behaviours. • PEN advances knowledge on impact and effective implementation of these policies. • We here describe the rationale and specific goals of PEN, and highlight innovations. Non-communicable diseases (NCDs) are the leading cause of global mortality. As the social and economic costs of NCDs have esca…
Social disparities in Disease Management Programmes for coronary heart disease in Germany
BACKGROUND: Disease Management Programmes (DMPs) aim to improve effectiveness and equity of care but may suffer from selective enrolment. We analysed social disparities in DMP enrolment among elderly patients with coronary heart disease (CHD) in Germany, taking into account contextual effects at municipality and primary care practice levels. METHODS: Cross-sectional analysis of effects of educational attainment and regional deprivation on physici…
Estimating completeness of cancer registration
STUDY OBJECTIVE--In recent years, capture-recapture methods have become increasingly popular in estimating completeness of disease registries. This study aimed to assess the performance of the two source capture-recapture method in estimating the completeness of cancer registration. DESIGN--The study was conducted in the population based cancer registry of Saarland, Germany, for which there are three main sources of notifications: reports by clin…
The need for expanding and re-focusing of statistical approaches in diagnostic research
Fitting statistical methodology to the need of diagnostic research In his contribution “Misguided efforts and future challenges for research on diagnostic tests”1 Dr Feinstein has identified major gaps and shortcomings in previous and current diagnostic research. While we fully agree with most of his criticisms, we would like to take issue with him over the role of statistics and mathematical formalisation in diagnostic research. In particular, w…
Debating the efficacy of smoking intervention strategies
Monitoring and projecting cancer incidence in Saarland, Germany, based on age-cohort analyses
STUDY OBJECTIVE--The aims were (1) to monitor and compare incidence rates of cancer from successive birth cohorts in Saarland over the period from 1968 to 1987; (2) to project cancer incidence in Saarland in 1988-2002 in order to provide guidelines for health policy planning. DESIGN--This was an ecological study of overlapping birth cohorts of women and men. SETTING--The study was population based involving the whole state of Saarland. PATIENTS--…
Revolutionar im Beruf
Revolutionar im Beruf
Monitoring and projecting cancer incidence in Saarland, Germany, based on age-cohort analyses
STUDY OBJECTIVE--The aims were (1) to monitor and compare incidence rates of cancer from successive birth cohorts in Saarland over the period from 1968 to 1987; (2) to project cancer incidence in Saarland in 1988-2002 in order to provide guidelines for health policy planning. DESIGN--This was an ecological study of overlapping birth cohorts of women and men. SETTING--The study was population based involving the whole state of Saarland. PATIENTS--…
A birth cohort analysis of the smoking epidemic in West Germany
STUDY OBJECTIVE--The aim was to provide insights in the spread of the smoking epidemic and eventual progress against cigarette smoking in West Germany. DESIGN--This was a retrospective birth cohort analysis based on a cross sectional national survey. SETTING--The survey was conducted in 1987 by the Ministry of Youth, Family and Health in order to identify priorities for health policy and promotion. The target population were all residents of Germ…
Estimating completeness of cancer registration
STUDY OBJECTIVE--In recent years, capture-recapture methods have become increasingly popular in estimating completeness of disease registries. This study aimed to assess the performance of the two source capture-recapture method in estimating the completeness of cancer registration. DESIGN--The study was conducted in the population based cancer registry of Saarland, Germany, for which there are three main sources of notifications: reports by clin…
Debating the efficacy of smoking intervention strategies
The need for expanding and re-focusing of statistical approaches in diagnostic research
Fitting statistical methodology to the need of diagnostic research In his contribution “Misguided efforts and future challenges for research on diagnostic tests”1 Dr Feinstein has identified major gaps and shortcomings in previous and current diagnostic research. While we fully agree with most of his criticisms, we would like to take issue with him over the role of statistics and mathematical formalisation in diagnostic research. In particular, w…
Effects of practitioner education, practitioner payment and reimbursement of patients’ drug costs on smoking cessation in primary care
Objective: To evaluate new strategies to enhance the promotion of smoking cessation in general practice. Design: Cluster randomised trial, 2×2 factorial design. Setting: 82 medical practices in Germany, including 94 general practitioners. Participants: 577 patients who smoked at least 10 cigarettes per day (irrespective of their intention to stop smoking) and were aged 36–75 years. Interventions: Provision of a 2-h physician group training in smo…
Odd odds interactions introduced through dichotomisation of continuous outcomes
BACKGROUND: Dichotomisation of continuous variables before analysis has frequently been criticised but, nonetheless, remains a common approach. We were interested in the effects of dichotomisation of an outcome variable when two predictors are examined. METHODS: Assuming a log-normally distributed continuous outcome, a three-level and a binary independent variable, we evaluated the results that would be obtained by logistic regression after dicho…
P1-60 European guidelines for colorectal cancer screening—initial standards
Introduction Colorectal cancer (CRC) is the 4th most common cause of cancer death worldwide. The efficacy of screening in reducing CRC mortality has been proven in RCTs. The EU recommends population-based screening with appropriate quality at each step in the screening process. Evidence-based, multidisciplinary European Guidelines for Quality Assurance in Colorectal Cancer Screening and Diagnosis have been developed by experts and will be publish…
P1-508 Oestrogen receptor β expression in colorectal cancer
Introduction The oestrogen receptor β (ERβ) is the primarily expressed ER in the large intestine and has been found to have inhibitory effects on colon cancer cells. We therefore investigated, whether the ERβ expression in tumour tissue from colorectal cancer (CRC) patients is associated with tumour/clinical characteristics. Methods We used tissue micro arrays consisting of paired normal and tumorous tissue samples from 1262 CRC cases of a German…
Using rate advancement periods for communicating the benefits of quitting smoking to older smokers
Smoking remains a strong risk factor for premature mortality, and smoking cessation remains highly beneficial also at older ages
Impact of national smoke-free legislation on home smoking bans
The findings suggest that smoke-free legislation does not lead to more smoking in smokers' homes. On the contrary, our findings demonstrate that smoke-free legislation may stimulate smokers to establish total smoking bans in their homes
Significance and Costs of Complex Biopsychosocial Health Care Needs in Elderly People
OBJECTIVE: To improve health care for the elderly, a consideration of biopsychosocial health care needs may be of particular importance-especially because of the prevalence of multiple conditions, mental disorders, and social challenges facing elderly people. The aim of the study was to investigate significance and costs of biopsychosocial health care needs in elderly people. METHODS: Data were derived from the 8-year follow-up of the ESTHER stud…
Inequalities in out-of-pocket payments for health care services among elderly Germans – results of a population-based cross-sectional study
This is the first study providing evidence of inequalities in OOPP in the German elderly population. Socio-economic and morbidity-related inequalities in OOPP and the resulting financial burden could be identified. The results of this study may contribute to the discussion about the mechanisms causing the observed inequalities and can thus help decision makers to consider them when adapting future regulations on OOPP
Association of Cardiometabolic Multimorbidity With Mortality
IMPORTANCE The prevalence of cardiometabolic multimorbidity is increasing. OBJECTIVE To estimate reductions in life expectancy associated with cardiometabolic multimorbidity. DESIGN, SETTING, AND PARTICIPANTS Age-and sex-adjusted mortality rates and hazard ratios (HRs) were calculated using individual participant data from the Emerging Risk Factors Collaboration (689 300 participants; 91 cohorts; years of baseline surveys: 1960-2007; latest morta…
Global, regional, and national disability-adjusted life years (Dalys) for 306 diseases and injuries and healthy life expectancy (Hale) for 188 countries, 1990–2013
Analysing horizontal equity in enrolment in Disease Management Programmes for coronary heart disease in Germany 2008–2010
Need-standardised DMP enrolment was fairly equitable across educational levels. Deprivation-related inequities in DMP enrolment favoured women living in less deprived areas relative to those living in areas with higher deprivation. Further research is needed to gain a better understanding of the mechanisms that contribute to deprivation-related horizontal inequities in DMP enrolment among women
Social disparities in Disease Management Programmes for coronary heart disease in Germany
BACKGROUND: Disease Management Programmes (DMPs) aim to improve effectiveness and equity of care but may suffer from selective enrolment. We analysed social disparities in DMP enrolment among elderly patients with coronary heart disease (CHD) in Germany, taking into account contextual effects at municipality and primary care practice levels. METHODS: Cross-sectional analysis of effects of educational attainment and regional deprivation on physici…
Worldwide trends in diabetes since 1980
BACKGROUND: One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age-standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are affecting the number of adults with diabetes. METHODS: We pooled data from population-ba…
Demographic ageing and the evolution of smoking-attributable mortality
Especially in men, actual SAM hardly declined despite a sharp drop in age-standardised SAM, indicating that decreases were largely compensated by demographic ageing. The increasing number of deaths resulting from the ageing population will lead to a steady increase in SAM in the near future if no efforts are taken to curb smoking
Smoking prevalence and attributable disease burden in 195 countries and territories, 1990–2015
BACKGROUND: The scale-up of tobacco control, especially after the adoption of the Framework Convention for Tobacco Control, is a major public health success story. Nonetheless, smoking remains a leading risk for early death and disability worldwide, and therefore continues to require sustained political commitment. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) offers a robust platform through which global, regional, and na…
Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2016
BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of risk factor exposure and attributable burden of disease. By providing estimates over a long time series, this study can monitor risk exposure trends critical to health surveillance and inform policy debates on the importance of addressing risks in context. METHODS: We used the comparative risk assessment framework dev…
Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015
IMPORTANCE: Cancer is the second leading cause of death worldwide. Current estimates on the burden of cancer are needed for cancer control planning. OBJECTIVE: To estimate mortality, incidence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs) for 32 cancers in 195 countries and territories from 1990 to 2015. EVIDENCE REVIEW: Cancer mortality was estimated using vital registration system dat…
Alcohol use and burden for 195 countries and territories, 1990–2016
BACKGROUND: Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions. With our comprehensive approach to health accounting within the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we generated improved estimates of alcohol use and alcohol-attributable deaths and disability-adjus…
Screen Time, Physical Activity and Self-Esteem in Children
Screen time is a central activity of children’s daily life and jeopardizes mental health. However, results appear inconclusive and are often based on small cross-sectional studies. We aimed to investigate the temporal sequence of the association between screen time and self-esteem taking into account further indirect effects through family or friendship relationship. In our population-based birth cohort study (baseline November 2000−November 2001…
Medicine (38 obras) · Environmental health (28 obras) · Population (20 obras) · Demography (17 obras) · Internal Medicine (12 obras) · Public health (12 obras) · Cohort (11 obras) · Cohort study (11 obras) · Disease (11 obras) · Internal Medicine (11 obras)