Vence L Bonham
Datos Biográficos
| ID | 97698 |
|---|---|
| NOMBRE | Vence L Bonham |
| NOMBRES | Vence L |
| APELLIDO | Bonham |
| FIRMA | BONHAM V L |
| AFILIACIONES | National Human Genome Research Institute |
| ORCID | 0000-0002-3649-5442 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 28 |
| TOTAL DE CITAS | 80 |
| TOTAL COMO AUTOR | 28 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 2004 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2026 |
| ÍNDICE H | 5 |
First-in-human gene therapy clinical trials in the media
Promising results reported in genetic therapy clinical trials and recent US Food and Drug Administration approvals have attracted media attention. This critical content analysis examines themes and narrative framings present in feature articles published in US news media sources following patients involved in first-in-human clinical trials of genetic therapies. Articles were collected through focused searches across US news websites and LexisNexi…
Measuring (Mis)trust in the age of Covid-19
Our findings reveal that for individuals living with sickle cell disease, the worry of infection and the severity of their individual disease were more important in shaping views towards vaccine research participation than medical mistrust
An Examination of John Henryism in Adults Living with Sickle Cell Disease
Background John Henryism (JH) is a behavioral predisposition for high-effort coping with adversity. JH has been associated with hypertension in Black Americans with low socioeconomic status (SES) and is also found to be associated with psychological well-being. Sickle cell disease (SCD), a rare genetic disease largely affecting Black Americans in the United States, presents as a chronic condition that may benefit from a deeper understanding of th…
Assessing Bias Toward a Black or White Simulated Patient with Obesity in a Virtual Reality-Based Genomics Encounter
Interpersonal bias based on weight and race is widespread in the clinical setting; it is crucial to investigate how emerging genomics technologies will interact with and influence such biases in the future. The current study uses a virtual reality (VR) simulation to investigate the influence of apparent patient race and provision of genomic information on medical students’ implicit and explicit bias toward a virtual patient with obesity. Eighty-f…
Bidirectional Relationship Between Sickle Cell Disease and Food Insecurity
Introduction: In the United States, sickle cell disease (SCD)-the homozygous inheritance of a point mutation within the beta-globin chain of hemoglobin-affects between 80,000 and 100,000 people. Adequate nutrition can influence the pathophysiology of SCD, and individuals with SCD who are undernourished are more likely to have impaired immune function and disease exacerbation. Undernourishment is often caused by food insecurity (FI), which is defi…
Herstory as an Important Force in Bioethics
This tribute celebrates the life and work of Marian Gray Secundy (1938–2002), who was the first director of the National Center for Bioethics in Research and Health Care, a passionate advocate for health equity, a visionary scholar, and a skilled editor and collaborator. Within the tribute are several short remembrances in which individuals describe their association with Secundy to honor her as a leader, friend, scholar, advocate, and teacher in…
Examining resilience of individuals living with sickle cell disease in the Covid-19 pandemic
Resilience declined during the COVID-19 pandemic but was still associated with better physical and mental health outcomes. Future studies should investigate the relationship between resilience and sociodemographic factors
Navigating Access to Cancer Care
Our combined analyses suggest that both system-level and patient-level barriers limit patient access to precision cancer medicine options. Additionally, we found that these barriers may exist not only for traditionally underserved patients, but also for resourced and insured patients trying to access precision cancer medicine
Ethical issues in genetics and infectious diseases research
Treatment decision-making in sickle cell disease patients
Social and behavioral science at the forefront of genomics
Blending Insights from Implementation Science and the Social Sciences to Mitigate Inequities in Screening for Hereditary Cancer Syndromes
Genomic screening to identify people at high risk for adult-onset hereditary conditions has potential to improve population health. However, if not equitably accessible, genomics-informed screening programs will exacerbate existing health inequities or give rise to new ones. To realize the disease prevention potential of these screening tools, we need strategies to broaden their reach. We propose a conceptual framework that merges insights from i…
Defining and Achieving Health Equity in Genomic Medicine
The potential of genomics to improve health comes with the peril that the benefits will not be equitably available to all populations. Existing health disparities can be exacerbated if the implementation of genomic medicine does not intentionally focus on health equity. Defining what health equity means in the context of genomics and outlining how it can be achieved is important for the future of the field. Strategies to improve health equity i…
A Comparison of Physicians' and Nurse Practitioners' Use of Race in Clinical Decision-Making
Physicians had more knowledge of genetic variation and used patients' race less in the clinical decision-making process than NPs. We speculate that these differences may be related to differences in discipline-specific clinical training and approaches to clinical care. Further exploration of these differences is needed, including examination of physicians' and NPs' beliefs about race, how they use race in disease screening and treatment, and if t…
Defining and Achieving Health Equity in Genomic Medicine
The potential of genomics to improve health comes with the peril that the benefits will not be equitably available to all populations. Existing health disparities can be exacerbated if the implementation of genomic medicine does not intentionally focus on health equity. Defining what health equity means in the context of genomics and outlining how it can be achieved is important for the future of the field. Strategies to improve health equity inc…
Physician Knowledge of Human Genetic Variation, Beliefs About Race and Genetics, and Use of Race in Clinical Decision-making
Should Electronic Health Record-Derived Social and Behavioral Data Be Used in Precision Medicine Research
Precision medicine research initiatives aim to use participants' electronic health records (EHRs) to obtain rich longitudinal data for large-scale precision medicine studies. Although EHRs vary widely in their inclusion and formatting of social and behavioral data, these data are essential to investigating genetic and social factors in health disparities. We explore possible biases in collecting, using, and interpreting EHR-based social and behav…
Primary Care Physicians' Collection, Comfort, and Use of Race and Ethnicity in Clinical Practice in the United States
Purpose: The clinical utility of race and ethnicity has been debated. It is important to understand if and how race and ethnicity are communicated and collected in clinical settings. We investigated physicians' self-reported methods of collecting a patient's race and ethnicity in the clinical encounter, their comfort with collecting race and ethnicity, and associations with use of race in clinical decision-making. Methods: A national cross-sectio…
Genomics for all in the 21st century
As the field of genomics enters the second decade after the completion of the International Human Genome Project, human genomics research is still far from reflective of the ancestral diversity found in global populations. This special issue of the Journal of Community Genetics brings together a global perspective on the need for researchers and health care professionals to support achievable milestones that will enhance global ancestral diversit…
Taking a Stand
There is a longstanding debate about genetics research into intelligence. Some scholars question the value of focusing on genetic contributions to intelligence in a society where social and environmental determinants powerfully influence cognitive ability and educational outcomes. Others warn that censoring certain research questions, such as inquiries about genetic differences in intellectual potential, compromises academic freedom. Still others…
Physicians’ Anxiety Due to Uncertainty and Use of Race in Medical Decision Making
BACKGROUND: The explicit use of race in medical decision making is contested. Researchers have hypothesized that physicians use race in care when they are uncertain. OBJECTIVES: The aim of this study was to investigate whether physician anxiety due to uncertainty (ADU) is associated with a higher propensity to use race in medical decision making. RESEARCH DESIGN: This study included a national cross-sectional survey of general internists. SUBJECT…
Goal‐striving stress and the mental health of college‐educated Black American Men
The present study examined the relationship between goal-striving stress and well-being in a survey of 399 college-educated Black American men who were members of a Black fraternal organization. Regression analyses revealed that goal-striving stress was associated with decreased psychological well-being, controlling for demographics and various psychosocial factors. When asked to explain their failure to reach life goals, half of the men attribut…
Is race medically relevant? A qualitative study of physicians' attitudes about the role of race in treatment decision-making
Mixed Race
This article presents the findings of a qualitative study of multiracial individuals' understanding of identity, race and human genetic variation. The debate regarding the correlation between race, genetics and disease has expanded, but limited empirical data has been collected regarding the lay public's perspective. Participants in this study explore their identity and its relationships to their health care interactions. Participants also share …
Effects of Racial Discrimination and Health Behaviors on Mental and Physical Health of Middle-Class African American Men
This research is an examination of the effects of racial discrimination and health-promoting behaviors on the physical and mental health of a sample of 399 well-educated African American men. One would think that the attainment of higher education would increase health-promoting behaviors and might decrease discriminatory experiences that impact health. However, regression analysis indicated a more complex picture. Health-promoting behaviors were…
Effects of Racial Discrimination and Health Behaviors on Mental and Physical Health of Middle-Class African American Men
This research is an examination of the effects of racial discrimination and health-promoting behaviors on the physical and mental health of a sample of 399 well-educated African American men. One would think that the attainment of higher education would increase health-promoting behaviors and might decrease discriminatory experiences that impact health. However, regression analysis indicated a more complex picture. Health-promoting behaviors were…
Race and ethnicity in the genome era
The vast amount of biological information that is now available through the completion of the Human Genome Project presents opportunities and challenges. The genomic era has the potential to advance an understanding of human genetic variation and its role in human health and disease. A challenge for genomics research is to understand the relationships between genomics, race, and ethnicity and the implications of uncovering these relationships. Ro…
John Henryism and Self-Reported Physical Health Among High–Socioeconomic Status African American Men
We performed a cross-sectional survey of high–socioeconomic status (SES) African American men and their health to examine the relationship between John Henryism (the strong behavioral predisposition to directly confront barriers to upward social mobility) and selfreported physical health status. We found a positive association between John Henryism and better physical health among high-SES African American men. The study of social and behavioral …
Is race medically relevant? A qualitative study of physicians' attitudes about the role of race in treatment decision-making
Mixed Race
This article presents the findings of a qualitative study of multiracial individuals' understanding of identity, race and human genetic variation. The debate regarding the correlation between race, genetics and disease has expanded, but limited empirical data has been collected regarding the lay public's perspective. Participants in this study explore their identity and its relationships to their health care interactions. Participants also share …
Physician Knowledge of Human Genetic Variation, Beliefs About Race and Genetics, and Use of Race in Clinical Decision-making
John Henryism and Self-Reported Physical Health Among High–Socioeconomic Status African American Men
We performed a cross-sectional survey of high–socioeconomic status (SES) African American men and their health to examine the relationship between John Henryism (the strong behavioral predisposition to directly confront barriers to upward social mobility) and selfreported physical health status. We found a positive association between John Henryism and better physical health among high-SES African American men. The study of social and behavioral …
Bonham Et Al. Responds
My coauthors and I are pleased that our brief research report stimulated Griggs and Mallinger’s letter to the editor and has provided the authors an opportunity to elaborate on our conclusions. That “African Americans who are less healthy have somehow failed to overcome barriers to achieve good health” was not a finding or a subtle conclusion of our study. Our perspective is more nuanced and recognizes the multiple factors that contribute to heal…
Race and ethnicity in the genome era
The vast amount of biological information that is now available through the completion of the Human Genome Project presents opportunities and challenges. The genomic era has the potential to advance an understanding of human genetic variation and its role in human health and disease. A challenge for genomics research is to understand the relationships between genomics, race, and ethnicity and the implications of uncovering these relationships. Ro…
Effects of Racial Discrimination and Health Behaviors on Mental and Physical Health of Middle-Class African American Men
This research is an examination of the effects of racial discrimination and health-promoting behaviors on the physical and mental health of a sample of 399 well-educated African American men. One would think that the attainment of higher education would increase health-promoting behaviors and might decrease discriminatory experiences that impact health. However, regression analysis indicated a more complex picture. Health-promoting behaviors were…
Mixed Race
This article presents the findings of a qualitative study of multiracial individuals' understanding of identity, race and human genetic variation. The debate regarding the correlation between race, genetics and disease has expanded, but limited empirical data has been collected regarding the lay public's perspective. Participants in this study explore their identity and its relationships to their health care interactions. Participants also share …
Goal‐striving stress and the mental health of college‐educated Black American Men
The present study examined the relationship between goal-striving stress and well-being in a survey of 399 college-educated Black American men who were members of a Black fraternal organization. Regression analyses revealed that goal-striving stress was associated with decreased psychological well-being, controlling for demographics and various psychosocial factors. When asked to explain their failure to reach life goals, half of the men attribut…
Is race medically relevant? A qualitative study of physicians' attitudes about the role of race in treatment decision-making
Physicians’ Anxiety Due to Uncertainty and Use of Race in Medical Decision Making
BACKGROUND: The explicit use of race in medical decision making is contested. Researchers have hypothesized that physicians use race in care when they are uncertain. OBJECTIVES: The aim of this study was to investigate whether physician anxiety due to uncertainty (ADU) is associated with a higher propensity to use race in medical decision making. RESEARCH DESIGN: This study included a national cross-sectional survey of general internists. SUBJECT…
Taking a Stand
There is a longstanding debate about genetics research into intelligence. Some scholars question the value of focusing on genetic contributions to intelligence in a society where social and environmental determinants powerfully influence cognitive ability and educational outcomes. Others warn that censoring certain research questions, such as inquiries about genetic differences in intellectual potential, compromises academic freedom. Still others…
Primary Care Physicians' Collection, Comfort, and Use of Race and Ethnicity in Clinical Practice in the United States
Purpose: The clinical utility of race and ethnicity has been debated. It is important to understand if and how race and ethnicity are communicated and collected in clinical settings. We investigated physicians' self-reported methods of collecting a patient's race and ethnicity in the clinical encounter, their comfort with collecting race and ethnicity, and associations with use of race in clinical decision-making. Methods: A national cross-sectio…
Genomics for all in the 21st century
As the field of genomics enters the second decade after the completion of the International Human Genome Project, human genomics research is still far from reflective of the ancestral diversity found in global populations. This special issue of the Journal of Community Genetics brings together a global perspective on the need for researchers and health care professionals to support achievable milestones that will enhance global ancestral diversit…
Should Electronic Health Record-Derived Social and Behavioral Data Be Used in Precision Medicine Research
Precision medicine research initiatives aim to use participants' electronic health records (EHRs) to obtain rich longitudinal data for large-scale precision medicine studies. Although EHRs vary widely in their inclusion and formatting of social and behavioral data, these data are essential to investigating genetic and social factors in health disparities. We explore possible biases in collecting, using, and interpreting EHR-based social and behav…
Blending Insights from Implementation Science and the Social Sciences to Mitigate Inequities in Screening for Hereditary Cancer Syndromes
Genomic screening to identify people at high risk for adult-onset hereditary conditions has potential to improve population health. However, if not equitably accessible, genomics-informed screening programs will exacerbate existing health inequities or give rise to new ones. To realize the disease prevention potential of these screening tools, we need strategies to broaden their reach. We propose a conceptual framework that merges insights from i…
Defining and Achieving Health Equity in Genomic Medicine
The potential of genomics to improve health comes with the peril that the benefits will not be equitably available to all populations. Existing health disparities can be exacerbated if the implementation of genomic medicine does not intentionally focus on health equity. Defining what health equity means in the context of genomics and outlining how it can be achieved is important for the future of the field. Strategies to improve health equity i…
A Comparison of Physicians' and Nurse Practitioners' Use of Race in Clinical Decision-Making
Physicians had more knowledge of genetic variation and used patients' race less in the clinical decision-making process than NPs. We speculate that these differences may be related to differences in discipline-specific clinical training and approaches to clinical care. Further exploration of these differences is needed, including examination of physicians' and NPs' beliefs about race, how they use race in disease screening and treatment, and if t…
Defining and Achieving Health Equity in Genomic Medicine
The potential of genomics to improve health comes with the peril that the benefits will not be equitably available to all populations. Existing health disparities can be exacerbated if the implementation of genomic medicine does not intentionally focus on health equity. Defining what health equity means in the context of genomics and outlining how it can be achieved is important for the future of the field. Strategies to improve health equity inc…
Physician Knowledge of Human Genetic Variation, Beliefs About Race and Genetics, and Use of Race in Clinical Decision-making
Ethical issues in genetics and infectious diseases research
Treatment decision-making in sickle cell disease patients
Social and behavioral science at the forefront of genomics
Herstory as an Important Force in Bioethics
This tribute celebrates the life and work of Marian Gray Secundy (1938–2002), who was the first director of the National Center for Bioethics in Research and Health Care, a passionate advocate for health equity, a visionary scholar, and a skilled editor and collaborator. Within the tribute are several short remembrances in which individuals describe their association with Secundy to honor her as a leader, friend, scholar, advocate, and teacher in…
Examining resilience of individuals living with sickle cell disease in the Covid-19 pandemic
Resilience declined during the COVID-19 pandemic but was still associated with better physical and mental health outcomes. Future studies should investigate the relationship between resilience and sociodemographic factors
Navigating Access to Cancer Care
Our combined analyses suggest that both system-level and patient-level barriers limit patient access to precision cancer medicine options. Additionally, we found that these barriers may exist not only for traditionally underserved patients, but also for resourced and insured patients trying to access precision cancer medicine
Assessing Bias Toward a Black or White Simulated Patient with Obesity in a Virtual Reality-Based Genomics Encounter
Interpersonal bias based on weight and race is widespread in the clinical setting; it is crucial to investigate how emerging genomics technologies will interact with and influence such biases in the future. The current study uses a virtual reality (VR) simulation to investigate the influence of apparent patient race and provision of genomic information on medical students’ implicit and explicit bias toward a virtual patient with obesity. Eighty-f…
Bidirectional Relationship Between Sickle Cell Disease and Food Insecurity
Introduction: In the United States, sickle cell disease (SCD)-the homozygous inheritance of a point mutation within the beta-globin chain of hemoglobin-affects between 80,000 and 100,000 people. Adequate nutrition can influence the pathophysiology of SCD, and individuals with SCD who are undernourished are more likely to have impaired immune function and disease exacerbation. Undernourishment is often caused by food insecurity (FI), which is defi…
Medicine (22 obras) · Biology (12 obras) · Gerontology (11 obras) · Psychology (11 obras) · Health care (10 obras) · Health equity (10 obras) · BRCA gene mutations in cancer (9 obras) · Political science (9 obras) · Genetics (8 obras) · Public health (8 obras)