A case-control study to evaluate the effectiveness of mass neonatal BCG vaccination among Canadian Indians

Datos Bibliográficos

ID11037474
AutoresT K Young (0000-0003-2727-8347), Earl S Hershfield
Año1986
Volumen76
Número7
Páginas783-786
Fecha de publicación1986-07-01
Peer ReviewedSí
Open AccessNo
TipoARTICLE
RevistaAmerican Journal of Public Health (JOURNAL)
Identificadores de la revistaISSN: 0090-0036 • E-ISSN: 1541-0048
EditorialAmerican Public Health Association (PUBLISHER • US)
DOI10.2105/ajph.76.7.783
PMID3717464
OpenAlexW2028868711
IdiomaEN
Citas recibidas8
Referencias citadas9

This paper reports a case-control study to assess the protective effect of BCG (bacille Calmette-Guérin) vaccination among Indian infants in Manitoba, Canada. A record of past BCG vaccination was found in 49 per cent of the tuberculosis cases, compared to 77 per cent of the controls, yielding a relative risk of 0.30. Stratified analysis, controlling for age, increased the relative risk to 0.39 (95% confidence interval 0.22 - 0.69). The preventive fraction was 44 per cent. Non-differential misclassification of exposure status could have occurred; if this was adjusted for, the relative risk would be reduced. If only bacteriologically confirmed cases were analyzed, the age-adjusted relative risk was 0.27. The protective effect of BCG vaccination in the newborn among Manitoba Indians is therefore at least 60 per cent. The implications for health policy in this population are further discussed

Attributable risk · BCG vaccine · Confidence interval · Environmental health · Population · Relative risk · Tuberculosis · Vaccination · Demography · Immune responses and vaccinations · Immunology · Internal Medicine · Medicine · Neonatal Respiratory Health Research · Pediatric health and respiratory diseases · Pediatrics