Australian Languages

Their nature and development

Datos Bibliográficos

ID11747413
AutoresBarry Alpher (autor de correspondencia), W H Berrettini, R Alexander (0000-0001-6762-035X), Robyn Moran (0000-0002-7465-4766), T N Ferraro, W H Vogel
Año2005
Volumen34
Número5
Páginas795-805
Fecha de publicación2005-01-01
Peer ReviewedSí
Open AccessNo
TipoARTICLE
RevistaLanguage in Society (JOURNAL)
Identificadores de la revistaISSN: 0047-4045 • E-ISSN: 1469-8013
EditorialCambridge University Press (PUBLISHER • US)
DOI10.1097/00041444-199422000-00003
OpenAlexW8055251
IdiomaEN
Citas recibidas7

C57BL/6J mice, in two-bottle choice paradigms, show increased oral morphine consumption, compared with DBA/2J mice. To determine whether this C57 morphine preference reflects differences in the receptor-mediated, reward-based action of morphine (as opposed to pharmacokinetic or gustatory differences), three experiments were performed. Consistent with previous two-bottle choice experiments, C57 mean (+/- S.D.) morphine consumption was 18 +/- 3 mg/kg/day, while the DBA mice consumed 1.4 +/- 1.2 mg/kg/day. Intraperitoneal naltrexone produced a 50% decrease in C57 morphine consumption (p < 0.01), while DBA mice showed no change. Consumption of fluid from the control bottle was not changed for either strain. Fifteen and 30 min after oral consumption of a morphine solution, plasma levels of morphine and its glucuronide derivative were not different between these two strains. C57 mice maintained a daily morphine intake of approximately 20 mg/kg across morphine concentrations of 0.05-0.4 mg/ml. These experiments suggest that the difference in oral morphine preference between C57 and DBA mice represents a reward-based mechanism which is mediated through opiate receptors

Linguistics · Sociology · Australian Indigenous Culture and History · Linguistic Variation and Morphology · Multilingual Education and Policy · Philosophy