Multiple myeloma bone lesions in skeletal remains

Report of two known cases from the 20th century CAL Milano Cemetery Skeletal Collection

Datos Bibliográficos

ID12371150
AutoresL Biehler‐gomez (0000-0001-6674-7850, LABANOF, Laboratorio di Antropologia e Odontologia Forense, Sezione di Medicina Legale, Dipartimento di Scienze Biomediche per la Salute Università degli Studi di Milano Milan Italy, autor de correspondencia), Gaia Giordano (0000-0002-6081-0596, LABANOF, Laboratorio di Antropologia e Odontologia Forense, Sezione di Medicina Legale, Dipartimento di Scienze Biomediche per la Salute Università degli Studi di Milano Milan Italy), Cristina Cattaneo (0000-0001-8273-0143, LABANOF, Laboratorio di Antropologia e Odontologia Forense, Sezione di Medicina Legale, Dipartimento di Scienze Biomediche per la Salute Università degli Studi di Milano Milan Italy)
Año2018
Volumen29
Número1
Páginas101-107
Fecha de publicación2018-10-10
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaInternational Journal of Osteoarchaeology (JOURNAL)
Identificadores de la revistaISSN: 1047-482X • E-ISSN: 1099-1212
EditorialWiley (PUBLISHER • GB)
DOI10.1002/oa.2721
OpenAlexW2898035601
IdiomaEN
Citas recibidas4
Referencias citadas27

Multiple myeloma (MM) is of special interest in anthropology, in particular in the differential diagnosis with metastatic carcinoma. In this paper, we present two cases of known MM and discuss the criteria for diagnosis in comparison with the literature. Two skeletons from the identified CAL Milano Cemetery Skeletal Collection were selected for the antemortem clinical diagnosis of MM in their associated medical data. Each lesion observed during the anthropological analysis was reported and considered. Lesions were observed in both cases in the pelvis, sacrum, ribs, vertebrae, scapulae, proximal ends of femora and humeri as well as in the skull. Moreover, they presented similar morphological traits. Consequently, lesions in MM are multifocal, round, lytic, sharply demarcated, relatively uniformly small, and specifically located in highly vascularized areas of the skeleton. These results are consistent with data from the literature and strengthen the criteria for diagnosis of the condition

Carcinoma · Differential diagnosis · Lesion · Metastatic carcinoma · Multiple myeloma · Pathology · Pelvis · Rib cage · Sacrum · Skeletal survey · Skeleton (computer programming · Skull · Bone health and treatments · Bone Tumor Diagnosis and Treatments · Medicine · Multiple Myeloma Research and Treatments · Anatomy