Panax notoginseng saponins inhibits oxidative stress- induced human nucleus pulposus cell apoptosis and delays disc degeneration in vivo and in vitro

Datos Bibliográficos

ID14727700
AutoresDanqing Guo (0000-0002-9538-2237, Guangzhou University of Chinese Medicine, autor de correspondencia), Miao Yu (0000-0002-7625-6315, Guangzhou University of Chinese Medicine), Huizhi Guo (0000-0003-3952-0030, Guangzhou University of Chinese Medicine), Min Zeng (0009-0006-3980-8666, Guangzhou University of Chinese Medicine), Yang Shao (0000-0002-5854-3257, Guangzhou University of Chinese Medicine), Wei Deng (0000-0002-1243-3044, Guangzhou University of Chinese Medicine), Qiuli Qin (Guangzhou University of Chinese Medicine), Yongxian Li (0000-0002-4897-1194, Guangzhou University of Chinese Medicine), Shuncong Zhang (0000-0002-6212-9913), Shun-cong Zhang (Guangzhou University of Chinese Medicine, autor de correspondencia)
Año2024
Volumen319
NúmeroPt 1
Páginas117166
Fecha de publicación2024-01-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaJournal of Ethnopharmacology (JOURNAL)
Identificadores de la revistaISSN: 0378-8741 • E-ISSN: 1872-7573
EditorialElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2023.117166
PMID37716491
OpenAlexW4386785408
IdiomaEN
Referencias citadas38

Our study showed that PNS could protect HNP cells against apoptosis via autophagy inhibition and ameliorate disc degeneration in vivo, indicating its potential to be a therapeutic agent for IDD

Apoptosis · Autophagy · Biology · In vitro · In vivo · Intervertebral disc · Oxidative stress · Panax notoginseng · Pathology · TUNEL assay · Western blot · Chemistry · Medicine · Musculoskeletal pain and rehabilitation · Plant Toxicity and Pharmacological Properties · Spine and Intervertebral Disc Pathology · Anatomy · Biochemistry · Cell Biology · Pharmacology