Acute and subchronic oral toxicity assessment of the herbal formula Kai-Xin-San

Acute toxicity · Adverse effect · Alkaline phosphatase · Oral administration · Toxicity · Traditional medicine · Chemistry · Medicine · Pharmacological Effects of Natural Compounds · Phytochemistry and Biological Activities · Plant-based Medicinal Research · Internal Medicine · Pharmacology

• Evaluation of the toxicity and antimicrobial activity of hydroethanolic extract of Arrabidaea chica (Humb. & Bonpl.) B. Verl

  Open Access•Luciano Mafioleti, Iberê Ferreira da Silva et al.•Journal of Ethnopharmacology•2013

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• Toxicological evaluation of hydroethanolic extract of Helicteres sacarolha A. St.- Hil. et al

  Open Access•Sikiru Olaitan Balogun, Iberê Ferreira da Silva et al.•Journal of Ethnopharmacology•2014

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• Hydroethanolic extract of the inner stem bark of Cedrela odorata has low toxicity and reduces hyperglycemia induced by an overload of sucrose and glucose

  Open Access•Morenna Alana Giordani, Thiago Carvalho Mamede Collicchio et al.•Journal of Ethnopharmacology•2015

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• A representative prescription for emotional disease, Ding-Zhi-Xiao-Wan restores 5-HT system deficit through interfering the synthesis and transshipment in chronic mild stress-induced depressive rats

  Xian-Zhe Dong, Xian‐Zhe Dong et al.•Journal of Ethnopharmacology•2013

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• Toxicological evaluation of the hydroethanolic extract of Dilodendron bipinnatum Radlk

  Open Access•Clarisse Pinto Coelho de Azevedo Neta Mahon, Edson Moleta Colodel et al.•Journal of Ethnopharmacology•2014

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• Kai-xin-san improves cognitive impairment in D-gal and Aβ25-35 induced ad rats by regulating gut microbiota and reducing neuronal damage

  Open Access•Huijuan Wang, Lifen Zhou et al.•Journal of Ethnopharmacology•2024

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• Gut microbiota

  Open Access•Boru Li, Meijing Xu et al.•Journal of Ethnopharmacology•2023

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• Chinese medicine formula Kai-Xin-San ameliorates depression-like behaviours in chronic unpredictable mild stressed mice by regulating gut microbiota-inflammation-stress system

  Open Access•Cheng Cao, Mengqiu Liu et al.•Journal of Ethnopharmacology•2020

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• Evaluation of the chronic oral toxicity of the classical ancient prescription Kai-Xin-San

  Open Access•Haijing Zhang, Yifei Yang et al.•Journal of Ethnopharmacology•2025

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• Kai-Xin-San, a standardized traditional Chinese medicine formula, up-regulates the expressions of synaptic proteins on hippocampus of chronic mild stress induced depressive rats and primary cultured rat hippocampal neuron

  Open Access•Yue Zhu, Xiuzhu Duan et al.•Journal of Ethnopharmacology•2016

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• A randomized, placebo-controlled, double-blind study on the effects of SZL on patients with mild to moderate depressive disorder with comparison to fluoxetine

  Open Access•Yuan Hu, Yichen Wang et al.•Journal of Ethnopharmacology•2021

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• Evaluation of 43 species of Congolese medicinal plants used traditionally for the treatment of schistosomiasis leading to the isolation of an anti-schistosomal phaeophytin from Pseudolachnostylis maprouneifolia Pax

  Open Access•Kalunga Muya, Mbuyi Kalonji et al.•Journal of Ethnopharmacology•2023

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• Antidepressant effects of total phenols and total saponins of Kai-Xin-San mediated by synaptic plasticity induced by BDNF/TrkB/Akt pathway

  Open Access•Ya-Nan Tang, Yunfeng Bai et al.•Journal of Ethnopharmacology•2025

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• Acute and sub-chronic toxicity of an aqueous extract of the leaves of Herniaria glabra in rodents

  Open Access•Hamid Rhiouani, Jaouad El-Hilaly et al.•Journal of Ethnopharmacology•2008

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• Some pharmacological, toxicological and phytochemical investigations on Centaurea phyllocephala

  Open Access•Husni A A Twaij, Agnes Kery et al.•Journal of Ethnopharmacology•1983

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