Ficus hirta Vahl. ameliorates liver fibrosis by triggering hepatic stellate cell ferroptosis through GSH/GPX4 pathway

Datos Bibliográficos

ID14732255
AutoresYuxuan Yang (0009-0000-5292-713X, Jinan University), Yan Chen (0000-0003-4119-9688, Jinan University), Yanchun Chen (0009-0009-5918-3984), Dongge Feng (Jinan University), Huixing Wu (0009-0001-2491-2384, Guangdong Medical College), Changrui Long (Guangdong Medical College), Jianping Zhang (0000-0003-0815-009X, Jinan University), Jinghao Wang (0009-0006-5666-9645, First Affiliated Hospital of Jinan University), BenJie Zhou (0000-0001-5630-110X, Sun Yat-sen University, autor de correspondencia), Shasha Li (0000-0001-9177-8173, First Affiliated Hospital of Jinan University, autor de correspondencia), Shijian Xiang (0000-0002-7119-5728, Sun Yat-sen University, autor de correspondencia)
Año2024
Volumen334
Páginas118557
Fecha de publicación2024-11-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaJournal of Ethnopharmacology (JOURNAL)
Identificadores de la revistaISSN: 0378-8741 • E-ISSN: 1872-7573
EditorialElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.118557
PMID39009327
OpenAlexW4400623973
IdiomaEN
Citas recibidas2
Referencias citadas30

Ficus hirta Vahl triggered the ferroptosis of hepatic stellate cell by regulating the GSH/GPX4 pathway, thereby alleviating liver fibrosis in mice. Moreover, apigenin is a key compound in Ficus hirta Vahl responsible for the effective treatment of liver fibrosis

Antioxidant · Biology · Fibrosis · Hepatic fibrosis · Hepatic stellate cell · Liver fibrosis · Pathology · Traditional Chinese medicine · Traditional medicine · Ferroptosis and cancer prognosis · Kruppel-like factors research · Liver Disease Diagnosis and Treatment · Medicine · Biochemistry · Internal Medicine · Pharmacology