Effects of Banxia Xiexin Decoction on apoptosis of interstitial cells of Cajal via regulation of MiR-451-5p

An in vivo and in vitro study

Datos Bibliográficos

ID14739734
AutoresDi Zhang (0000-0002-9199-5634, Beijing University of Chinese Medicine), Ruimin Lu (0000-0002-6256-7147, Beijing University of Chinese Medicine), Mengwei Wang (0009-0001-6370-9266, Beijing University of Chinese Medicine), Jing Ji (0000-0002-3846-077X, Beijing University of Chinese Medicine), Shujing Zhang (0000-0001-7757-8482, Beijing University of Chinese Medicine), Shuyan Wang (0000-0001-5191-6359, Beijing University of Chinese Medicine, autor de correspondencia), Dongmei Zhang (0000-0001-6180-0253, Beijing University of Chinese Medicine, autor de correspondencia), Meng Chen (0000-0003-4503-5226, Beijing University of Chinese Medicine, autor de correspondencia)
Año2023
Volumen314
Páginas116606
Fecha de publicación2023-10-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaJournal of Ethnopharmacology (JOURNAL)
Identificadores de la revistaISSN: 0378-8741 • E-ISSN: 1872-7573
EditorialElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2023.116606
PMID37192721
OpenAlexW4376609008
IdiomaEN
Citas recibidas1
Referencias citadas40

Through this study, we demonstrated that BXD could promote ICCs proliferation and inhibit apoptosis via miR-451-5p and may involve the modulations of SCF/c-kit signaling, thus suggesting a new therapy basis for GI motility dysfunction from the perspective of modulation of ICCs apoptosis by targeting miR-451-5p

Apoptosis · Biology · Gene · Immunohistochemistry · In vivo · Interstitial cell of Cajal · Motility · Western blot · Chemistry · Gastrointestinal motility and disorders · Helicobacter pylori-related gastroenterology studies · Medicine · Polysaccharides and Plant Cell Walls · Biochemistry · Cell Biology · Genetics · Internal Medicine · Pharmacology