The acute toxic effect of Chinese medicine Fuzi is exacerbated in kidney yang deficiency mice due to metabolic difference

Datos Bibliográficos

ID14740488
AutoresHui Jiang (0000-0001-8393-8368, Second Affiliated Hospital of Zhejiang University), Xiaoyu Li (0000-0003-4438-9014, Second Affiliated Hospital of Zhejiang University), Fan Yang (0000-0003-2978-7102, Second Affiliated Hospital of Zhejiang University), Yang Fan (0009-0004-1290-4418), Junjie Wang (0000-0001-7953-4918, Second Affiliated Hospital of Zhejiang University), Yiyi Xie (Second Affiliated Hospital of Zhejiang University), Peilin Yu (0000-0002-8230-4061, Second Affiliated Hospital of Zhejiang University, autor de correspondencia)
Año2024
Volumen328
Páginas118036
Fecha de publicación2024-06-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaJournal of Ethnopharmacology (JOURNAL)
Identificadores de la revistaISSN: 0378-8741 • E-ISSN: 1872-7573
EditorialElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.118036
PMID38460575
OpenAlexW4392592022
IdiomaEN
Citas recibidas2
Referencias citadas13

In conclusion, our study showed that changes of the metabolic enzyme activity in individuals with different syndromes led to different toxic effects of Chinese medicines, emphasizing the crucial importance of considering individual physical syndromes in the clinical application of traditional Chinese medicine, and the significance of conducting safety evaluations and dose predictions on animal models with specific syndromes for traditional Chinese medicines

CYP3A4 · Cytochrome P450 · Kidney · Kidney disease · Metabolism · Pathology · Toxicity · Traditional Chinese medicine · Traditional medicine · Bioactive Natural Diterpenoids Research · Medicine · Pharmacological Effects of Natural Compounds · Plant-based Medicinal Research · Internal Medicine · Pharmacology