A novel phthalein component ameliorates neuroinflammation and cognitive dysfunction by suppressing the CXCL12/CXCR4 axis in rats with vascular dementia

Datos Bibliográficos

ID14740904
AutoresKai-Ting Ma (0009-0003-6933-3970, Sichuan University), Yi-Jin Wu (0000-0002-6169-9084, Sichuan University), Yuxin Yang (0009-0005-4068-9644, West China Medical Center of Sichuan University), Yu-Xin Yang, Ting Wu (0000-0002-2169-4334, Sichuan University), Chu Chen (0000-0003-3619-9202, Sichuan Academy of Traditional Chinese Medicine), Peng Fu (0009-0009-6501-1556, Sichuan University), Fu Peng (0000-0003-0289-4426), Junrong Du (0000-0003-3320-5785, Sichuan University, autor de correspondencia), Jun-rong Du, Cheng Peng (0000-0002-3770-586X, Chengdu University of Traditional Chinese Medicine, autor de correspondencia)
Año2024
Volumen328
Páginas118117
Fecha de publicación2024-06-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaJournal of Ethnopharmacology (JOURNAL)
Identificadores de la revistaISSN: 0378-8741 • E-ISSN: 1872-7573
EditorialElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.118117
PMID38548120
OpenAlexW4393187570
IdiomaEN
Citas recibidas1
Referencias citadas54

QBT effectively mitigated neuronal damage and cognitive dysfunction in VaD rats, exerting neuroprotective effects by suppressing neuroinflammatory response through inhibition of the CXCL12/CXCR4 axis

Biology · Chemokine · Dementia · Hippocampus · Inflammation · Microglia · Morris water navigation task · Neuroinflammation · Neuroprotection · PI3K/AKT/mTOR pathway · Protein kinase B · Signal transduction · Vascular dementia · Chemistry · Medicine · Neuroinflammation and Neurodegeneration Mechanisms · Neurological Disease Mechanisms and Treatments · Neurological disorders and treatments · Cell Biology · Immunology · Internal Medicine · Pharmacology