Indigo naturalis and its component tryptanthrin exert anti-angiogenic effect by arresting cell cycle and inhibiting Akt and FAK signaling in human vascular endothelial cells

Datos Bibliográficos

ID14745657
AutoresHsin-Ning Chang (Chang Gung University), Sheng-Teng Huang, Sheng‐Teng Huang (0000-0002-7495-6115, Chang Gung Memorial Hospital), Yuan-Chieh Yeh (0000-0002-9656-0269, Chang Gung Memorial Hospital), Hsin-Shih Wang, Hsin‐Shih Wang (Chang Gung University), Tzu-Hao Wang, Tzu‐Hao Wang (0000-0002-1418-7684, Chang Gung Memorial Hospital), Yi-Hong Wu (Chang Gung Memorial Hospital), Jong-Hwei S Pang, Jong‐Hwei S Pang (0000-0003-3432-0208, Chang Gung University, autor de correspondencia)
Año2015
Volumen174
Páginas474-481
Fecha de publicación2015-11-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaJournal of Ethnopharmacology (JOURNAL)
Identificadores de la revistaISSN: 0378-8741 • E-ISSN: 1872-7573
EditorialElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2015.08.050
PMID26341616
OpenAlexW1482472850
IdiomaEN
Citas recibidas5
Referencias citadas34

All together, these results demonstrated the anti-angiogenic effect of tryptanthrin, the acting component of indigo naturalis and revealed the underlying mechanism by inhibiting the cell cycle progression, cell migration and tube formation, likely mediated through blocking the Akt and FAK pathways

Angiogenesis · Apoptosis · Biology · Cell cycle · Chorioallantoic membrane · Cyclin A · Cyclin-dependent kinase · Endothelial stem cell · In vitro · Protein kinase B · Signal transduction · Bioactive Compounds and Antitumor Agents · Chemistry · Mast cells and histamine · Quinazolinone synthesis and applications · Biochemistry · Cancer Research · Cell Biology · Molecular Biology