Association between WHO cut-offs for childhood overweight and obesity and cardiometabolic risk

Datos Bibliográficos

ID15093046
AutoresMercedes De Onís (World Health Organization, autor de correspondencia), Cecilia Martínez-Costa, Cecilia Martínez‐Costa (0000-0003-1347-7521, Hospital Clínico Universitario de Valencia), Francisco Núñez (0000-0002-4166-3877, Hospital Clínico Universitario de Valencia), Georges Nguefack-Tsague, Georges Nguefack‐Tsague (0000-0002-3847-3490, Université de Yaoundé I), Angeles Montal (Hospital Clínico Universitario de Valencia), Juan Brines
Año2013
Volumen16
Número4
Páginas625-630
Fecha de publicación2013-04-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaPublic Health Nutrition (JOURNAL)
Identificadores de la revistaISSN: 1368-9800 • E-ISSN: 1475-2727
EditorialCambridge University Press (CUP) (PUBLISHER)
DOI10.1017/s1368980012004776
PMID23110804
OpenAlexW2024551751
IdiomaEN
Citas recibidas6
Referencias citadas19

Objective To examine the association between cardiovascular risk and childhood overweight and obesity using the BMI cut-offs recommended by the WHO. Design Children were classified as normal weight, overweight and obese according to the WHO BMI-for-age reference. Blood pressure, lipids, glucose, insulin, homeostasis model assessment–insulin resistance (HOMA-IR) and uric acid levels were compared across BMI groups. ANOVA and tests of linearity were used to assess overall mean differences across groups. Crude and adjusted odds ratios were calculated for adverse plasma levels of biochemical variables. Setting Paediatric care centres. Subjects Children ( n 149) aged 8–18 years. Results About 37 %, 22 % and 41 % of children were classified respectively as normal weight, overweight and obese. There were significant linear mean differences between BMI groups in systolic blood pressure, HDL-cholesterol, TAG, insulin, HOMA-IR and uric acid. Obese children were 10·6 times more likely than normal-weight children to have hypertension; OR for other associations were 60·2 (high insulin), 39·5 (HOMA-IR), 27·9 (TAG), 16·0 (HDL-cholesterol), 4·3 (LDL-cholesterol) and 3·6 (uric acid). Overweight children were more likely than normal-weight children to have hypertension (OR = 3·5), high insulin (OR = 28·2), high HOMA-IR (OR = 23·3) and high TAG (OR = 16·1). Nearly 92 % and 57 % of the obese and overweight children, respectively, had one or more risk factor. Conclusions Obesity and overweight defined using the WHO BMI-for-age cut-offs identified children with higher metabolic and vascular risk. These results emphasize the importance of prevention of overweight and obesity in childhood to reduce cardiovascular risk

Blood pressure · Body mass index · Childhood obesity · Insulin · Insulin resistance · Obesity · Odds ratio · Overweight · Risk factor · Uric acid · Birth, Development, and Health · Medicine · Obesity and Health Practices · Obesity, Physical Activity, Diet · Endocrinology · Internal Medicine