Vitamin D status is associated with underweight and stunting in children aged 6–36 months residing in the Ecuadorian Andes

Datos Bibliográficos

ID15097045
AutoresRana R Mokhtar (0000-0002-0796-6313, Boston University), Michael F Holick (0000-0001-6023-9062, Boston University, autor de correspondencia), Fernando Sempértegui (Central University of Ecuador), Jeffrey K Griffiths (Tufts University), Bertha Estrella (0000-0002-1444-9824, Central University of Ecuador), Lynn L Moore (0000-0002-1028-919X), Matthew P Fox (0000-0002-5132-7818, Massachusetts Department of Public Health), Davidson H Hamer (0000-0002-4700-1495, Tufts University)
Año2018
Volumen21
Número11
Páginas1974-1985
Fecha de publicación2018-08-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaPublic Health Nutrition (JOURNAL)
Identificadores de la revistaISSN: 1368-9800 • E-ISSN: 1475-2727
EditorialCambridge University Press (CUP) (PUBLISHER)
DOI10.1017/s1368980017002816
PMID29162164
OpenAlexW2769844665
IdiomaEN
Citas recibidas4
Referencias citadas52

Objective There is limited knowledge on vitamin D status of children residing in the Andes and its association with undernutrition. We evaluated the vitamin D status of children residing in a low socio-economic status (SES) setting in the Ecuadorian Andes and assessed the association between vitamin D status, stunting and underweight. We hypothesized that children who were underweight would have lower serum 25-hydroxyvitamin D (25(OH)D) levels and lower 25(OH)D levels would be associated with a higher risk of stunting. Design We conducted a cross-sectional secondary analysis of a randomized controlled trial, the Vitamin A, Zinc and Pneumonia study. Children had serum 25(OH)D concentrations measured. A sensitivity analysis was undertaken to determine a vitamin D cut-off specific for our endpoints. Associations between serum 25(OH)D and underweight (defined as weight-for-age Z -score≤−1) and stunting (defined as height-for-age Z -score≤−2) were assessed using multivariate logistic regression. Setting Children residing in five low-SES peri-urban neighbourhoods near Quito, Ecuador. Subjects Children ( n 516) aged 6–36 months. Results Mean serum 25(OH)D concentration was 58·0 ( sd 17·7) nmol/l. Sensitivity analysis revealed an undernutrition-specific 25(OH)D cut-off of Conclusions Low serum 25(OH)D levels were more common in underweight and stunted Ecuadorian children

Body mass index · Logistic regression · Malnutrition · Malnutrition in children · Overweight · Underweight · Vitamin · Vitamin D and neurology · Child Nutrition and Water Access · Demography · Medicine · Obesity, Physical Activity, Diet · Vitamin D Research Studies · Internal Medicine · Pediatrics