Vitamin D status in mothers with pre-eclampsia and their infants
A case–control study from Serbia, a country without a vitamin D fortification policy
Datos Bibliográficos
| ID | 15097463 |
|---|---|
| Autores | Marija Djekic-Ivankovic (0000-0001-7423-1029, University of Belgrade), Hope A Weiler (McGill University), Hope Weiler, Glenville Jones (0000-0001-7402-3473, Queen's University), Martin Kaufmann (0000-0003-0163-2205, Queen's University), Jovana Kaludjerovic (Harvard University), Vesna Aleksic-Velickovic, Vesna Aleksić‐Veličković (University of Belgrade), Ljuba M Mandic (0000-0002-6620-1230, University of Belgrade), Maria Glibetić (University of Belgrade, autor de correspondencia) |
| Año | 2017 |
| Volumen | 20 |
| Número | 10 |
| Páginas | 1825-1835 |
| Fecha de publicación | 2017-07-01 |
| Open Access | Sí |
| Tipo | ARTICLE |
| Revista | Public Health Nutrition (JOURNAL) |
| Identificadores de la revista | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Editorial | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980016000409 |
| PMID | 27087002 |
| OpenAlex | W2340682162 |
| Idioma | EN |
| Citas recibidas | 1 |
| Referencias citadas | 53 |
Objective The objective of the present study was to determine if vitamin D intake and status are associated with pre-eclampsia in a country without a vitamin D fortification policy. Design A case–control study of pregnancies with (case) and without (control) pre-eclampsia was conducted from January to April when UVB is minimal. Maternal and cord blood obtained at delivery were measured for plasma 25-hydroxycholecalciferol (25-OH-D 3 ), 3-epimer of 25-OH-D 3 (3-epi-25-OH-D 3 ) and 24,25-dihydroxycholecalciferol (24,25-(OH) 2 D 3 ) by LC–MS/MS and maternal 1,25-dihydroxyvitamin D (1,25-(OH) 2 D). Differences between groups were tested with ANOVA and Bonferroni post hoc tests ( P Setting Clinical Center of Serbia. Subjects Pregnant women with and without pre-eclampsia ( n 60) and their infants. Results Exogenous vitamin D intake (0·95–16·25 μg/d (38–650 IU/d)) was not significantly different between groups. Women with pre-eclampsia delivered infants at an earlier gestational age and had significantly lower mean total plasma 25-hydroxyvitamin D (25-OH-D; case: 11·2 ( sd 5·1); control: 16·1 ( sd 5·7) ng/ml; P =0·0006), 25-OH-D 3 (case: 10·0 ( sd 4·9); control: 14·2 ( sd 5·8) ng/ml; P =0·002), 3-epi-25-OH-D 3 (case: 0·5 ( sd 0·2); control: 0·7 ( sd 0·2) ng/ml; P =0·0007) and 1,25-(OH) 2 D (case: 56·5 ( sd 26·6); control: 81·0 ( sd 25·7) pg/ml; P =0·018), while 24,25-(OH) 2 D 3 was not different between groups. Infants did not differ in total plasma 25-OH-D, 25-OH-D 3 , 3-epi-25-OH-D 3 and 24,25-(OH) 2 D 3 , but the mean proportion of 3-epi-25-OH-D 3 was higher in the infant case group (case: 7·9 ( sd 1·1); control: 7·0 ( sd 1·4) % of total 25-OH-D 3 ; P =0·005). Conclusions A high prevalence of vitamin D deficiency, as defined by plasma 25-OH-D
Animal science · Biology · Eclampsia · Fortification · Gestational age · Obstetrics · Pregnancy · Vitamin · Vitamin D and neurology · vitamin D deficiency · Chemistry · Medicine · Pregnancy and Medication Impact · Pregnancy and preeclampsia studies · Vitamin D Research Studies · Food Science · Internal Medicine
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| Citas por año | 0,11 |
|---|---|
| Intervalo de citas | 2017 - 2017 (1) |
| Altamente citado | No |