Sickle Cell Anaemia Prevalence among Newborns in the Brazilian Amazon-Savanna Transition Region
Datos Bibliográficos
Sickle cell anaemia is one of the most common hemoglobinopathies worldwide and an important public health problem in Brazil. This study evaluated the prevalence of sickle cell anaemia and its traits in newborns from the Amazon-Savanna Transition Region in the state of Maranhão, Brazil. A cross-sectional study was carried out, based on data from neonatal screening tests performed in 2013-2015 in Maranhão. The Hardy-Weinberg theorem was applied to analyse the frequency of expected homozygotes based on HbSS phenotype. A spatial-temporal distribution analysis was performed to delimit the regions with the greatest number of newborn cases with sickle cell anaemia. Of 283,003 newborns, 162 were found to have sickle cell anaemia, while 10,794 had a sickle cell trait, with a prevalence of 0.05% and 3.8%, respectively. The prevalence of expected homozygotes was higher in the North Region and in the state capital of Maranhão. This study may contribute to existing social and public health actions or the creation of new strategies for sickle cell disease in endemic areas in Brazil to improve the quality of life
Amazon rainforest · Anemia · Biology · Disease · Environmental health · Geography · Pathology · Public health · Sickle cell anemia · Sickle cell trait · Demography · Folate and B Vitamins Research · Hemoglobinopathies and Related Disorders · Iron Metabolism and Disorders · Medicine · Ecology · Internal Medicine · Pediatrics
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