Free Fatty Acids Are Associated with the Cognitive Functions in Stroke Survivors
Datos Bibliográficos
| ID | 15470992 |
|---|---|
| Autores | Dariusz Kotlęga (0000-0002-3116-9656, State Higher Vocational School in Głogów, autor de correspondencia), Barbara Peda (State Higher Vocational School in Głogów), Joanna Palma (0000-0003-0620-3776, Pomeranian Medical University), Agnieszka Zembroń-Łacny (0000-0001-7596-9850, University of Zielona Góra), Monika Gołąb-Janowska (0000-0002-4934-9698, Pomeranian Medical University), Marta Masztalewicz (0000-0002-9479-0212, Pomeranian Medical University), Przemysław Nowacki (0000-0002-6536-2905, Pomeranian Medical University), Małgorzata Szczuko (0000-0001-9808-0624, Pomeranian Medical University) |
| Año | 2021 |
| Volumen | 18 |
| Número | 12 |
| Páginas | 6500-6500 |
| Fecha de publicación | 2021-06-16 |
| Peer Reviewed | Sí |
| Open Access | Sí |
| Tipo | ARTICLE |
| Revista | International Journal of Environmental Research and Public Health (JOURNAL) |
| Identificadores de la revista | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Editorial | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph18126500 |
| PMID | 34208689 |
| OpenAlex | W3168219095 |
| Idioma | EN |
| Referencias citadas | 41 |
Ischemic stroke is a leading cause of motor impairment and psychosocial disability. Although free fatty acids (FFA) have been proven to affect the risk of stroke and potentially dementia, the evidence of their impact on cognitive functions in stroke patients is lacking. We aimed to establish such potential relationships. Seventy-two ischemic stroke patients were prospectively analysed. Their cognitive functions were assessed seven days post-stroke and six months later as follow-up ( n = 41). Seven days post-stroke analysis of serum FFAs levels showed direct correlations between Cognitive Verbal Learning Test (CVLT) and the following FFAs: C20:4n6 arachidonic acid and C20:5n3 eicosapentaenoic acid, while negative correlations were observed for C18:3n3 linolenic acid (ALA), C18:4 n3 stearidonic acid and C23:0 tricosanoic acid. Follow-up examination with CVLT revealed positive correlations with C15:0 pentadecanoid acid, C18:3n6 gamma linoleic acid, SDA, C23:0 tricosanoic acid and negative correlations with C14:0 myristic acid and C14:1 myristolenic acids. Several tests (Trail Making Test, Stroop Dots Trail, Digit Span Test and Verbal Fluency Test) were directly correlated mainly with C14:0 myristic acid and C14:1 myristolenic acid, while corresponding negatively with C18:1 vaccinic acid, C20:3n3 cis-11-eicosatrienoic acid, C22:1/C20:1 cis11- eicosanic acid and C20:2 cis-11-eicodienoic acid. No correlations between Montreal Cognitive Assessment (MOCA) test performed on seventh day, and FFAs levels were found. Saturated fatty acids play a negative role in long-term cognitive outcomes in stroke patients. The metabolic cascade of polyunsaturated fatty acids (n3 PUFA) and the synthesis of (AA) can be involved in pathogenesis of stroke-related cognitive impairment
Arachidonic acid · California Verbal Learning Test · Cognition · Dementia · Disease · Eicosapentaenoic acid · Fatty acid · Myristic acid · Palmitic acid · Polyunsaturated fatty acid · Psychiatry · Stroke (engine · Stroop effect · Verbal memory · Biochemical Analysis and Sensing Techniques · Chemistry · Fatty Acid Research and Health · Medicine · Neurological Disease Mechanisms and Treatments · Psychology · Biochemistry · Internal Medicine
| Velocidad de citación | historical |
|---|---|
| Altamente citado | No |