Habenular Involvement in Response to Subcallosal Cingulate Deep Brain Stimulation for Depression
Datos Bibliográficos
| ID | 15517298 |
|---|---|
| Autores | Gavin J B Elias (0000-0002-7495-550X, University of Toronto), Jürgen Germann (0000-0003-0995-8226, University of Toronto), Aaron Loh (0000-0001-5297-6775, University of Toronto), Alexandre Boutet (0000-0001-6942-5195, University Health Network), Aditya Pancholi (University Health Network), Michelle E Beyn (0000-0002-4111-8692, University of Toronto), Venkat Bhat (0000-0002-8768-1173, University Health Network), D Blake Woodside (0000-0001-6833-3264, University Health Network), Peter Giacobbe (0000-0001-6642-6221, Sunnybrook Health Science Centre), Sherril H Kennedy (0000-0001-5339-7185, University of Toronto), Sidney H Kennedy, Andres M Lozano (0000-0001-8257-3694, Krembil Foundation, autor de correspondencia) |
| Año | 2022 |
| Volumen | 13 |
| Páginas | 810777-810777 |
| Fecha de publicación | 2022-02-04 |
| Peer Reviewed | Sí |
| Open Access | Sí |
| Tipo | ARTICLE |
| Revista | Frontiers in Psychiatry (JOURNAL) |
| Identificadores de la revista | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Editorial | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2022.810777 |
| PMID | 35185654 |
| OpenAlex | W4210697984 |
| Idioma | EN |
| Referencias citadas | 79 |
The habenula (Hb) is a small, evolutionarily conserved epithalamic structure implicated in functions such as reward and mood regulation. Prior imaging work suggests that Hb's structural and functional properties may relate to treatment response in depression and other mood disorders. We used multimodal MRI techniques to investigate the potential involvement of Hb in response to subcallosal cingulate area deep brain stimulation (SCC-DBS) for treatment-resistant mood disorders. Using an automated segmentation technique, we compared Hb volume at baseline and at a subsequent post-operative timepoint (4.4 ± 3.0 years after surgery) in a cohort of 32 patients who received SCC-DBS. Clinical response to treatment (≥50% decrease in HAMD-17 from baseline to 12 months post-operation) was significantly associated with longitudinal Hb volume change: responders tended to have increased Hb volume over time, while non-responders showed decreased Hb volume ( t = 2.4, p = 0.021). We additionally used functional MRI (fMRI) in a subcohort of SCC-DBS patients ( n = 12) to investigate immediate within-patient changes in Hb functional connectivity associated with SCC-DBS stimulation. Active DBS was significantly associated with increased Hb connectivity to several prefrontal and corticolimbic regions (TFCE-adjusted p Bonferroni < 0.0001), many of which have been previously implicated in the neurocircuitry of depression. Taken together, our results suggest that Hb may play an important role in the antidepressant effect of SCC-DBS
Deep brain stimulation · Depression (economics · Major depressive disorder · Mood · Mood disorders · Psychiatry · Psychosurgery · Stimulation · Advanced Neuroimaging Techniques and Applications · Functional Brain Connectivity Studies · Medicine · Neurological disorders and treatments · Neuroscience · Psychology · Internal Medicine
| Velocidad de citación | historical |
|---|---|
| Altamente citado | No |