Rested-Baseline Responsivity of the Ventral Striatum Is Associated With Caloric and Macronutrient Intake During One Night of Sleep Deprivation

Background: Sleep loss contributes to obesity through a variety of mechanisms, including neuroendocrine functioning, increased hunger, and increased food intake. Additionally, sleep loss alters functional activation within brain regions associated with reward and behavioral control. However, it remains unknown whether individual differences in baseline neural functioning can predict eating behaviors during total sleep deprivation (TSD). We used functional magnetic resonance imaging (fMRI) to test the hypothesis that individuals with increased baseline responsiveness within reward regions are more vulnerable to TSD-induced overeating. Methods: N = 45 subjects completed several fMRI scans during a single pre-TSD session that included performance on the Multi-Source Interference Task (MSIT) and the n- back task. Subjects returned to the laboratory for an overnight TSD session, during which they were given ad libitum access to 10,900 kcal of food. Leftover food and packaging were collected every 6 h (00:00, 06:00, and 12:00) to measure total food consumption. Subjects reported sleepiness every hour and performed a food rating task every 3 h. Results: Functional activation within the ventral striatum during the MSIT and n -back positively correlated with total caloric and carbohydrate intake during the final 6 h (06:00-12:00) of TSD. Activation within the middle and superior temporal gyri during the MSIT also correlated with total carbohydrates consumed. Food consumption did not correlate with subjective sleepiness, hunger, or food desire. Conclusions: Individual differences in neural activity of reward processing areas (i.e., nucleus accumbens) prior to sleep deprivation are associated with an individual's propensity to overeat during subsequent sleep deprivation. This suggests that individual differences within reward processing pathways are potential key factors in sleep loss related overeating. Sleep loss and obesity are tightly linked. Both phenomena have been associated with increased neural activation in regions associated with reward, inhibitory control, and disrupted dopamine signaling. Elevated baseline reward sensitivity in the ventral striatum appears to be further compounded by sleep deprivation induced dysfunction in the reward neurocircuitry, increasing the likelihood of overeating. Our findings suggest that large individual differences in baseline responsiveness of hedonic reward pathways may modulate the association between sleep loss and obesity

Audiology · Body weight · Caloric intake · Caloric theory · Circadian rhythm · Dopamine · Sleep (system call · Sleep deprivation · Striatum · Ventral striatum · Advanced Neuroimaging Techniques and Applications · Medicine · Neuroscience · Parkinson's Disease Mechanisms and Treatments · Psychology · Sleep and Wakefulness Research · Internal Medicine

• Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index

  Open Access•Shahrad Taheri, Ling Lin et al.•PLoS Medicine•2004

  Añadir item

• Reward, dopamine and the control of food intake

  Open Access•Nora D Volkow, Gene-Jack Wang et al.•Trends in Cognitive Sciences•2011

  Añadir item

• Brief Communication

  Open Access•Karine Spiegel, Esra Tasali et al.•Annals of Internal Medicine•2004

  Añadir item

• Meta-Analysis of Short Sleep Duration and Obesity in Children and Adults

  Francesco P Cappuccio, Frances M Taggart et al.•Sleep•2008

  Añadir item

• National Sleep Foundation’s sleep time duration recommendations

  Open Access•Max Hirshkowitz, Kaitlyn Whiton et al.•Sleep Health•2015

  Añadir item

• The assessment and analysis of handedness

  Open Access•R C Oldfield•Neuropsychologia•1971

  Añadir item