Association of Transfusion With Risks of Dementia or Alzheimer’s Disease
A Population-Based Cohort Study
Datos Bibliográficos
| ID | 15519516 |
|---|---|
| Autores | Shih-Yi Lin (China Medical University Hospital), Wu-Huei Hsu (0000-0002-0743-7841, China Medical University), C C Lin (0000-0002-9625-6216, China Medical University Hospital), Cheng-Chieh Lin, Cheng‐Li Lin (0000-0001-9926-3668, China Medical University Hospital), Hung-Chieh Yeh (China Medical University), Chia‐Hung Kao (0000-0002-6368-3676, Asia University, autor de correspondencia) |
| Año | 2019 |
| Volumen | 10 |
| Páginas | 571-571 |
| Fecha de publicación | 2019-08-16 |
| Peer Reviewed | Sí |
| Open Access | Sí |
| Tipo | ARTICLE |
| Revista | Frontiers in Psychiatry (JOURNAL) |
| Identificadores de la revista | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Editorial | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2019.00571 |
| PMID | 31474887 |
| OpenAlex | W2963665574 |
| Idioma | EN |
| Referencias citadas | 52 |
Purpose: The association between neurodegenerative diseases and transfusion remains to be investigated. Methods: The study population comprised 63,813 patients who underwent a blood transfusion and 63,813 propensity score-matched controls between 2000 and 2010. Data were obtained from the Taiwan National Health Insurance Research Database, which is maintained by the National Health Research Institutes. A Cox regression analysis was conducted to elucidate the relationship between blood transfusions and the risk of dementia. Results: A multivariate Cox regression analysis of factors, such as age, sex, cardiovascular ischemia disease, and depression, revealed that patients who underwent a blood transfusion showed a 1.73-fold higher risk of dementia [95% confidence interval (CI) = 1.62-1.84] and a 1.37-fold higher risk of Alzheimer's disease (AD) [95% CI = 1.13-1.66] than those who did not. Patients who received a transfusion of washed red blood cells showed a 2.37-fold higher risk of dementia (95% CI = 1.63-3.44) than those who did not. Conclusion: Blood transfusion, especially transfusion of any type of red blood cells is associated with an increased risk of dementia
Blood transfusion · Cohort · Cohort study · Confidence interval · Dementia · Depression (economics · Disease · Population · Proportional hazards model · Erythropoietin and Anemia Treatment · Hemoglobinopathies and Related Disorders · Medicine · Neurological and metabolic disorders · Internal Medicine
| Velocidad de citación | historical |
|---|---|
| Altamente citado | No |