DNA Methylation Basis in the Effect of White Matter Integrity Deficits on Cognitive Impairments and Psychopathological Symptoms in Drug-Naive First-Episode Schizophrenia
Datos Bibliográficos
| ID | 15523637 |
|---|---|
| Autores | Xiaofen Zong (Central South University), Qinran Zhang (0000-0003-1251-7229, Wuhan University), Changchun He (University of Electronic Science and Technology of China), Xinyue Huang (0009-0004-5496-0880, University of Electronic Science and Technology of China), Jiangbo Zhang (0000-0002-5546-7949, University of Electronic Science and Technology of China), Gaohua Wang (0000-0002-8947-9921, Wuhan University), Luxian Lv (0000-0002-3963-660X, Henan Psychiatric Hospital), D Sang (Xinxiang Medical University), Xiufen Zou (0000-0001-5294-0764, Wuhan University, autor de correspondencia), Huafu Chen (0000-0002-4062-4753, University of Electronic Science and Technology of China, autor de correspondencia), Junjie Zheng (0000-0002-3031-3556, Nanjing Brain Hospital, autor de correspondencia), Maolin Hu (0000-0001-8477-9928, Renmin Hospital of Wuhan University, autor de correspondencia) |
| Año | 2021 |
| Volumen | 12 |
| Páginas | 777407-777407 |
| Fecha de publicación | 2021-12-13 |
| Open Access | Sí |
| Tipo | ARTICLE |
| Revista | Frontiers in Psychiatry (JOURNAL) |
| Identificadores de la revista | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Editorial | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.777407 |
| PMID | 34966308 |
| OpenAlex | W4200464714 |
| Idioma | EN |
| Citas recibidas | 1 |
| Referencias citadas | 3 |
Background: Mounting evidence from diffusion tensor imaging (DTI) and epigenetic studies, respectively, confirmed the abnormal alterations of brain white matter integrity and DNA methylation (DNAm) in schizophrenia. However, few studies have been carried out in the same sample to simultaneously explore the WM pathology relating to clinical behaviors, as well as the DNA methylation basis underlying the WM deficits. Methods: We performed DTI scans in 42 treatment-naïve first-episode schizophrenia patients and 38 healthy controls. Voxel-based method of fractional anisotropy (FA) derived from DTI was used to assess WM integrity. Participants' peripheral blood genomic DNAm status, quantified by using Infinium® Human Methylation 450K BeadChip, was examined in parallel with DTI scanning. Participants completed Digit Span test and Trail Making test, as well as Positive and Negative Syndrome Scale measurement. We acquired genes that are differentially expressed in the brain regions with abnormal FA values according to the Allen anatomically comprehensive atlas, obtained DNAm levels of the corresponding genes, and then performed Z-test to compare the differential epigenetic-imaging associations (DEIAs) between the two groups. Results: Significant decreases of FA values in the patient group were in the right middle temporal lobe WM, right cuneus WM, right anterior cingulate WM, and right inferior parietal lobe WM, while the significant increases were in the bilateral middle cingulate WM ( P s Conclusion: Schizophrenia may not cause widespread neuropathological changes, but subtle alterations affecting local cingulum WM, which may play a critical role in positive symptoms and cognitive impairments. This imaging-epigenetics study revealed for the first time that DNAm of genes enriched in neuronal, immunologic, and cognitive processes may serve as the basis in the effect of WM deficits on clinical behaviors in schizophrenia
Biology · Cognition · Cuneus · DNA methylation · dNaM · Fractional anisotropy · Magnetic resonance imaging · Neuropsychology · Psychiatry · Schizophrenia (object-oriented programming · White matter · Wisconsin Card Sorting Test · Advanced Neuroimaging Techniques and Applications · Functional Brain Connectivity Studies · Medicine · Neuroscience · Psychology · Schizophrenia research and treatment · Genetics
| Citas por año | 0,33 |
|---|---|
| Intervalo de citas | 2023 - 2023 (1) |
| Altamente citado | No |