Structural-functional connectivity decoupling reveals neural differences associated with subtypes of nonsuicidal self-injury among female depressive adolescents

Datos Bibliográficos

ID15524759
AutoresLan Hu (0000-0003-3705-1162, The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China), Lizhong Hu (0009-0006-8599-9678, University of Electronic Science and Technology of China, autor de correspondencia), Kena Li (University of Electronic Science and Technology of China), Hui He (0000-0001-7981-2180, University of Electronic Science and Technology of China), Shaoqing Li (University of Electronic Science and Technology of China), Nan Qiu (0000-0002-0562-0298, University of Electronic Science and Technology of China), Guocheng Zhao (0000-0003-0388-6137, University of Electronic Science and Technology of China), Tingyu Hu (University of Electronic Science and Technology of China), Yong Chen (0000-0001-8240-1286, University of Electronic Science and Technology of China), Cheng Luo (0000-0002-4603-6020, University of Electronic Science and Technology of China)
Año2026
Volumen17
Páginas1775531-1775531
Fecha de publicación2026-02-19
Open AccessSí
TipoARTICLE
RevistaFrontiers in Psychiatry (JOURNAL)
Identificadores de la revistaISSN: 1664-0640 • E-ISSN: 1664-0640
EditorialFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2026.1775531
PMID41799811
OpenAlexW7130522755
IdiomaEN
Referencias citadas69

These findings indicate that SC-FC coupling patterns distinguish NSSI subtypes in depressed female adolescents, with more severe NSSI associated with altered coupling in prefrontal, precuneus, and inferior frontal regions involved in executive control and attentional processing. The right subgenual anterior cingulate cortex-showing multiple clinical correlations-emerges as a potential target for early intervention of NSSI behavior. These findings highlight the utility of SC-FC coupling as a neural marker for NSSI subtyping and intervention planning

Association (psychology · Correlation · Diffusion MRI · Functional connectivity · Functional magnetic resonance imaging · Inferior frontal gyrus · Magnetic resonance imaging · Middle frontal gyrus · Neuroimaging · Precuneus · Attention Deficit Hyperactivity Disorder · Functional Brain Connectivity Studies · Suicide and Self-Harm Studies