Dammarane Sapogenins Improving Simulated Weightlessness-Induced Depressive-Like Behaviors and Cognitive Dysfunction in Rats
Datos Bibliográficos
| ID | 15525331 |
|---|---|
| Autores | Qiong Wang (0000-0003-3376-1925, Southwest Medical University), Dong Li (0000-0002-9480-993X, Southwest Medical University), Mengdi Wang (0000-0002-0092-6044, Southwest Medical University), Shanguang Chen (0000-0002-7030-8196, China Astronaut Research and Training Center, autor de correspondencia), Shanshan Li (0000-0001-5116-3588, Southwest Medical University), Yongbing Chen (0000-0002-7595-092X, Beijing Shijitan Hospital), Weiqian He (Southwest Medical University), Hong Zhang (0000-0003-2057-8427, Southwest Medical University), Yongliang Zhang (0000-0003-3294-5503, China Astronaut Research and Training Center), Alberto Carlos Pires Dias (0000-0003-3641-3248, Southwest Medical University), Sijin Yang (0000-0002-7145-1285, Southwest Medical University, autor de correspondencia), Xinmin Liu (0000-0003-2042-5703, Southwest Medical University, autor de correspondencia) |
| Año | 2021 |
| Volumen | 12 |
| Páginas | 638328-638328 |
| Fecha de publicación | 2021-03-26 |
| Peer Reviewed | Sí |
| Open Access | Sí |
| Tipo | ARTICLE |
| Revista | Frontiers in Psychiatry (JOURNAL) |
| Identificadores de la revista | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Editorial | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.638328 |
| PMID | 33841208 |
| OpenAlex | W3148945566 |
| Idioma | EN |
| Referencias citadas | 3 |
Background: Our studies demonstrated that the space environment has an impact on the brain function of astronauts. Numerous ground-based microgravity and social isolation showed that the space environment can induce brain function damages in humans and animals. Dammarane sapogenins (DS), an active fraction from oriental ginseng, possesses neuropsychic protective effects and has been shown to improve depression and memory. This study aimed to explore the effects and mechanisms of DS in attenuating depressive-like behaviors and cognitive deficiency induced by simulated weightlessness and isolation [hindlimb suspension and isolation (HLSI)] in rats. Methods: Male rats were orally administered with two different doses of DS (37.5, 75 mg/kg) for 14 days, and huperzine-A (1 mg/kg) served as positive control. Rats were subjected to HLSI for 14 days except the control group during drug administration. The depressive-like behaviors were then evaluated by the open-field test, the novel object recognition test, and the forced swimming test. The spatial memory and working memory were evaluated by the Morris water maze (MWM) test, and the related mechanism was further explored by analyzing the activity of choline acetyltransferase (ChAT), acetylcholinesterase (AChE), and superoxide dismutase (SOD) in the hippocampus of rats. Results: The results showed that DS treatment significantly reversed the HLSI-induced depressive-like behaviors in the open-field test, the novel object recognition test, and the forced swimming test and improved the HLSI-induced cognitive impairment in the MWM test. Furthermore, after DS treatment, the ChAT and SOD activities of HLSI rats were increased while AChE activity was significantly suppressed. Conclusions: These findings clearly demonstrated that DS might exert a significant neuropsychic protective effect induced by spaceflight environment, driven in part by the modulation of cholinergic system and anti-oxidation in the hippocampus
Acetylcholinesterase · Antidepressant · Behavioural despair test · Dizocilpine · Ginseng · Hippocampus · Morris water navigation task · Nissl body · NMDA receptor · Open field · Tail suspension test · Biochemical effects in animals · Chemistry · Medicinal Plants and Bioactive Compounds · Medicine · Psychology · Spaceflight effects on biology · Biochemistry · Internal Medicine · Pharmacology
| Velocidad de citación | historical |
|---|---|
| Altamente citado | No |