Treatment of Resistant Depression

Background: This pilot study explores a therapeutic setting combining transcranial direct current stimulation (tDCS) and mindfulness-based cognitive therapy (MBCT) for patients with drug-resistant depression. tDCS has shown efficacy for depression treatment and improvement could be maintained with the combination with mindfulness, which has shown depression relapse-prevention properties. Methods: Thirty-one treatment-resistant depressed patients have been assigned to our experimental treatment condition [tDCS combined with MBCT ( n = 15)] or to a control condition [tDCS combined with relaxation ( n = 16)]. Patients have completed both an intensive treatment block (eight consecutive days) and a single remind session 2 weeks after the intensive treatment. Clinical (depression, anxiety, and rumination) and cognitive (general cognitive functioning, mental flexibility, and working memory) symptoms of depression have been assessed through different questionnaires at baseline (t0), after the first block of treatment (t1), and after the remind session (t2). Results: Results seem to indicate a positive impact of both treatment conditions on clinical and cognitive symptoms of depression at t1. However, the treatment condition combining tDCS with mindfulness has been found to better maintain clinical improvements at t2 regarding some clinical [Montgomery-Åsberg Depression Rating Scale (MADRS) and Sadness and Anger Ruminative Inventory (SARI)] and cognitive variables (Digit Span-F and Digit Span-B). Conclusion: Based on the current observations, a multi-disciplinary treatment approach combining tDCS and MBCT might be effective in resistant depressed patients in the long run, even though further clinical research is necessary

Anxiety · Cognition · Cognitive therapy · Depression (economics · Developmental psychology · Major depressive disorder · Memory span · Mindfulness · Mindfulness-based cognitive therapy · Psychiatry · Psychotherapist · Rating scale · Rumination · Stimulation · Transcranial Direct Current Stimulation · Treatment-resistant depression · Working memory · Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes · Attention Deficit Hyperactivity Disorder · Clinical Psychology · Psychology · Transcranial Magnetic Stimulation Studies

• The Application of Noninvasive Brain Stimulation to Enhance the First Week of Mindfulness Practice Among Novice Meditators with Chronic Worry

  Open Access•Mollie A McDonald, Mollie McDonald et al.•Mindfulness•2026

  Añadir item

• Neural mechanisms of attentional control in mindfulness meditation

  Open Access•Peter Malinowski•Frontiers in Neuroscience•2013

  Añadir item

• Short-term meditation training improves attention and self-regulation

  Open Access•Yi‐Yuan Tang, Yi-Yuan Tang et al.•Proceedings of the National…•2007

  Añadir item

• A New Depression Scale Designed to be Sensitive to Change

  Open Access•Stuart A Montgomery, Stuart Montgomery et al.•The British Journal of Psychiatry•1979

  Añadir item

• Mood-congruent recall of affectively toned stimuli

  Open Access•Georg E Matt, Carmelo Vazquez et al.•Clinical Psychology Review•1992

  Añadir item

• Mindfulness

  Open Access•Jon Kabat‐zinn, Jon Kabat-Zinn•Mindfulness•2015

  Añadir item

• Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation

  Open Access•Michael A Nitsche, Walter Paulus•The Journal of Physiology•2000

  Añadir item

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  Stefan G Hofmann, Alice T Sawyer et al.•Journal of Consulting and…•2010

  Añadir item

• Prevalence and Treatment of Mental Disorders, 1990 to 2003

  R C Kessler, Olga Demler et al.•New England Journal of Medicine•2005

  Añadir item

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  Open Access•Ziad S Nasreddine, Ziad Nasreddine et al.•Journal of the American…•2005

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• Emotion-regulation strategies across psychopathology

  Open Access•Amelia Aldao, Susan Nolen-Hoeksema et al.•Clinical Psychology Review•2010

  Añadir item

• Rethinking Rumination

  Open Access•Susan Nolen-Hoeksema, Susan Nolen–hoeksema et al.•Perspectives on Psychological…•2008

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• Mood-Congruent Attentional Bias in Dysphoria

  Ernst H W Koster, Rudi De Raedt et al.•Emotion•2005

  Añadir item

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  Jelena Spasojević, Lauren B Alloy•Emotion•2001

  Añadir item