Resuscitation with an Intact Cord Enhances Pulmonary Vasodilation and Ventilation with Reduction in Systemic Oxygen Exposure and Oxygen Load in an Asphyxiated Preterm Ovine Model

Datos Bibliográficos

ID15713176
AutoresPraveen Chandrasekharan (0000-0001-8727-3017, University at Buffalo, State University of New York, autor de correspondencia), Sylvia F Gugino (University at Buffalo, State University of New York), Justin Helman (University at Buffalo, State University of New York), Carmon Koenigsknecht (University at Buffalo, State University of New York), Lori Nielsen (University at Buffalo, State University of New York), Nicole Bradley (University at Buffalo, State University of New York), Jayasree Nair (0000-0003-3846-2027, University at Buffalo, State University of New York), Vikash Agrawal (0000-0002-9359-7197, Loma Linda University), Mausma Bawa (0000-0001-7973-7950, University at Buffalo, State University of New York), Andreina Mari (0000-0003-4300-0345, University at Buffalo, State University of New York), Munmun Rawat (0000-0001-9703-9857, University at Buffalo, State University of New York), Satyan Lakshminrusimha (0000-0001-6098-2155, University of California, Davis)
Año2021
Volumen8
Número4
Páginas307-307
Fecha de publicación2021-04-17
Open AccessSí
TipoARTICLE
RevistaChildren (JOURNAL)
Identificadores de la revistaISSN: 2227-9067 • E-ISSN: 2227-9067
EditorialMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/children8040307
PMID33920664
OpenAlexW3154905183
IdiomaEN
Citas recibidas2

(1) Background: Optimal initial oxygen (O 2 ) concentration in preterm neonates is controversial. Our objectives were to compare the effect of delayed cord clamping with ventilation (DCCV) to early cord clamping followed by ventilation (ECCV) on O 2 exposure, gas exchange, and hemodynamics in an asphyxiated preterm ovine model. (2) Methods: Asphyxiated preterm lambs (127-128 d) with heart rate 2 and titrated based on preductal saturations (SpO 2 ) with an intact cord for 5 min, followed by clamping. In ECCV, the cord was clamped, and PPV was initiated. (3) Results: Fifteen asphyxiated preterm lambs were randomized to DCCV (N = 7) or ECCV (N = 8). The inspired O 2 (40 ± 20% vs. 60 ± 20%, p 2 ) levels were significantly lower and peak pulmonary blood flow was higher with DCCV. (4) Conclusion: In asphyxiated preterm lambs, resuscitation with an intact cord decreased O 2 exposure load improved ventilation with an increase in peak pulmonary blood flow in the first 5 min

Anesthesia · Asphyxia · Cardiology · Neonatal resuscitation · Oxygen · Pulmonary hypertension · Resuscitation · Umbilical cord · Vasodilation · Ventilation (architecture · Cardiac Arrest and Resuscitation · Chemistry · Medicine · Neonatal Respiratory Health Research · Neuroscience of respiration and sleep

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