Retracted
Combined Effect of Silica Nanoparticles and Benzo[a]pyrene on Cell Cycle Arrest Induction and Apoptosis in Human Umbilical Vein Endothelial Cells
Datos Bibliográficos
| ID | 17801191 |
|---|---|
| Autores | Collins Otieno Asweto (0000-0003-3514-9836, Capital Medical University), Collins Asweto (Capital Medical University), Jing Wu (0000-0002-6559-4335, Capital Medical University), Hejing Hu (Capital Medical University), Lin Feng (0000-0001-7062-1281, Capital Medical University), Xiaozhe Yang (0000-0002-0190-5114, Capital Medical University), Junchao Duan (0000-0002-1455-304X, Capital Medical University, autor de correspondencia), Zhiwei Sun (0000-0003-4470-9743, Capital Medical University, autor de correspondencia) |
| Año | 2017 |
| Volumen | 14 |
| Número | 3 |
| Páginas | 289-289 |
| Fecha de publicación | 2017-03-09 |
| Peer Reviewed | Sí |
| Open Access | Sí |
| Tipo | ARTICLE |
| Revista | International Journal of Environmental Research and Public Health (JOURNAL) |
| Identificadores de la revista | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Editorial | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph14030289 |
| PMID | 28282959 |
| OpenAlex | W2593927517 |
| Idioma | EN |
| Citas recibidas | 1 |
| Referencias citadas | 43 |
Particulate matter (PM) such as ultrafine particulate matter (UFP) and the organic compound pollutants such as polycyclic aromatic hydrocarbon (PAH) are widespread in the environment. UFP and PAH are present in the air, and their presence may enhance their individual adverse effects on human health. However, the mechanism and effect of their combined interactions on human cells are not well understood. We investigated the combined toxicity of silica nanoparticles (SiNPs) (UFP) and Benzo[a]pyrene (B[a]P) (PAH) on human endothelial cells. Human umbilical vascular endothelial cells (HUVECs) were exposed to SiNPs or B[a]P, or a combination of SiNPs and B[a]P. The toxicity was investigated by assessing cellular oxidative stress, DNA damage, cell cycle arrest, and apoptosis. Our results show that SiNPs were able to induce reactive oxygen species generation (ROS). B[a]P, when acting alone, had no toxicity effect. However, a co-exposure of SiNPs and B[a]P synergistically induced DNA damage, oxidative stress, cell cycle arrest at the G2/M check point, and apoptosis. The co-exposure induced G2/M arrest through the upregulation of Chk1 and downregulation of Cdc25C, cyclin B1. The co-exposure also upregulated bax, caspase-3, and caspase-9, the proapoptic proteins, while down-regulating bcl-2, which is an antiapoptotic protein. These results show that interactions between SiNPs and B[a]P synergistically potentiated toxicological effects on HUVECs. This information should help further our understanding of the combined toxicity of PAH and UFP
Apoptosis · Benzo(a)pyrene · Biology · Carcinogen · Cell cycle · Cell cycle checkpoint · DNA · DNA damage · Downregulation and upregulation · In vitro · Oxidative stress · Reactive oxygen species · Toxicity · Umbilical vein · Air Quality and Health Impacts · Carcinogens and Genotoxicity Assessment · Chemistry · Toxic Organic Pollutants Impact · Biochemistry · Cell Biology
| Obras citantes distintas | 1 |
|---|---|
| Citas por año | 1 |
| Intervalo de citas | 2025 - 2025 (1) |
| Velocidad de citación | recent |
| Altamente citado | No |
| Tipos de cita | Neutras: 1 |