Inflammation, Depressive Symptomatology, and Coronary Artery Disease

Datos Bibliográficos

ID19307367
AutoresAd Appels (National Heart Foundation of Australia), Frits W Bär (National Heart Foundation of Australia), Jim Bär (National Heart Foundation of Australia), Catherine Bruggeman (National Heart Foundation of Australia), and Marc de Baets (National Heart Foundation of Australia)
Año2000
Volumen62
Número5
Páginas601-605
Fecha de publicación2000-09-01
Peer ReviewedSí
Open AccessNo
TipoARTICLE
RevistaPsychosomatic Medicine (JOURNAL)
Identificadores de la revistaISSN: 0033-3174 • E-ISSN: 1534-7796
EditorialOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/00006842-200009000-00001
PMID11020087
OpenAlexW1966046825
IdiomaEN
Citas recibidas36
Referencias citadas27

OBJECTIVE: Many patients feel exhausted or depressed before the onset of an acute coronary event, but little is known about the origin of these feelings. We tested the hypothesis that the depressive symptomatology is associated with a reactivation of latent viruses and inflammation of a coronary vessel. METHODS: A blood sample was drawn and a biopsy sample was obtained from the coronary lesion of 15 exhausted and 15 nonexhausted patients treated with directional coronary angioplasty because of severe angina. Blood samples were analyzed to measure antibody titers against Chlamydia pneumoniae, cytomegalovirus, and the cytokines interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha. The biopsy sample was analyzed for the presence of IL-1beta and TNF-alpha. RESULTS: Exhausted/depressed patients had higher antibody titers against cytomegalovirus, higher levels of C. pneumoniae immunoglobulin G, and higher levels of IL-1beta and TNF-alpha. No associations between the mental state of a patient and cytokine mRNA in the biopsy sample were found. CONCLUSIONS: The findings indicate that the mental state of angioplasty patients is positively associated with serological markers of inflammation. It remains to be seen whether the inflammation causes feelings of exhaustion, whether exhaustion and depression set the stage for inflammation, or whether existing feelings of exhaustion are amplified by the inflammation

Antibody · Biopsy · C-reactive protein · Coronary artery disease · Cytomegalovirus · Depression (economics) · Herpesviridae · Inflammation · Serology · Systemic inflammation · Tumor necrosis factor alpha · Viral disease · Virus · Cardiac Health and Mental Health · Immunology · Internal Medicine · Medicine · Stress Responses and Cortisol · Tryptophan and brain disorders