Adherence to antiretroviral therapy and its association with quality of life among people with HIV in the United States

Datos Bibliográficos

ID19440404
AutoresBekana K Tadese (0000-0001-5173-5427, Merck & Co., Inc., Rahway, NJ, USA (United States), autor de correspondencia), Fritha Hennessy (0000-0002-3387-5423, Adelphi Real World, Bollington, UK), Phoebe Salmon (Adelphi Real World, Bollington, UK), Tim Holbrook (Adelphi Real World, Bollington, UK), Girish Prajapati (Merck & Co., Inc., Rahway, NJ, USA (United States))
Año2024
Volumen36
Número12
Páginas1869-1881
Fecha de publicación2024-12-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaAIDS Care (JOURNAL)
Identificadores de la revistaISSN: 0954-0121 • E-ISSN: 1360-0451
EditorialInforma UK Limited (PUBLISHER • GB)
DOI10.1080/09540121.2024.2391439
PMID39159289
OpenAlexW4401690895
IdiomaEN
Citas recibidas6
Referencias citadas31

Adherence to antiretroviral therapy (ART) is critical for people with HIV (PWH) to achieve and maintain virologic suppression and minimize drug resistance. This study aimed to use real-world data to characterize ART adherence and its effect on quality of life (QoL) in PWH. Data were drawn from the Adelphi HIV Disease Specific ProgrammeTM, a cross-sectional survey of physicians and PWH in the United States, conducted June-October 2021. Demographic and clinical characteristics, ART adherence and treatment satisfaction for PWH were reported by physicians. PWH completed standardized QoL questionnaires. Adherence level was categorized into completely, mostly and less adherent. Regression analysis was used to investigate factors associated with adherence and the association between adherence and QoL measures. Of 578 PWH, 189 (32.7%) were not completely adherent. Having AIDS-defining illnesses, anxiety/depression or being symptomatic was significantly associated with lower adherence. Reasons for poor adherence included forgetting, difficulties integrating into routine and side effects. QoL scores were significantly higher in the completely adherent group. These findings highlight the strong association between suboptimal adherence and QoL among PWH and key factors and PWH reasons that may lead to suboptimal adherence. Interventions aimed at improving the QoL of PWH by understanding these factors are warranted

Antiretroviral therapy · Family medicine · Psychotherapist · Viral load · HIV-related health complications and treatments · HIV, Drug Use, Sexual Risk · HIV/AIDS Research and Interventions · Medicine · Psychology · Gerontology