Zoonotic Transmission of Tuberculosis Between Pastoralists and Their Livestock in South-East Ethiopia

Datos Bibliográficos

ID19528186
AutoresBalako Gumi (0000-0002-2049-4955, Jimma University), Esther Schelling (0000-0001-6444-0898, Swiss Tropical and Public Health Institute), Stefan Berg (0000-0001-9601-6573, Animal and Plant Health Agency), Rebuma Firdessa (Armauer Hansen Research Institute), Girume Erenso (Armauer Hansen Research Institute), Wondale Mekonnen (Armauer Hansen Research Institute), Elena Hailu (0000-0002-9358-0838, Armauer Hansen Research Institute), Ermias Melese (Jimma University), Jemal Hussein (Armauer Hansen Research Institute), Abraham Aseffa (0000-0002-8028-1150, Armauer Hansen Research Institute), Jakob Zinsstag (0000-0002-8899-6097, Swiss Tropical and Public Health Institute, autor de correspondencia)
Año2012
Volumen9
Número2
Páginas139-149
Fecha de publicación2012-06-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaEcoHealth (JOURNAL)
Identificadores de la revistaISSN: 1612-9202 • E-ISSN: 1612-9210
EditorialSpringer Science and Business Media LLC (PUBLISHER)
DOI10.1007/s10393-012-0754-x
PMID22526748
PMCIDPMC3415617
OpenAlexW2056965647
IdiomaEN
Citas recibidas4
Referencias citadas32

Despite huge global efforts in tuberculosis (TB) control, pastoral areas remain under-investigated. During two years sputum and fine needle aspirate (FNA) specimens were collected from 260 Ethiopian pastoralists of Oromia and Somali Regional States with suspected pulmonary TB and from 32 cases with suspected TB lymphadenitis. In parallel, 207 suspected tuberculous lesions were collected from cattle, camels and goats at abattoirs. All specimens were processed and cultured for mycobacteria; samples with acid-fast stained bacilli (AFB) were further characterized by molecular methods including genus and deletion typing as well as spoligotyping. Non-tuberculous mycobacteria (NTM) were sequenced at the 16S rDNA locus. Culturing of AFB from human sputum and FNA samples gave a yield of 174 (67%) and 9 (28%) isolates, respectively. Molecular typing was performed on 173 of these isolates and 160 were confirmed as Mycobacterium tuberculosis, three as M. bovis, and the remaining 10 were typed as NTMs. Similarly, 48 AFB isolates (23%) yielded from tuberculous lesions of livestock, of which 39 were molecular typed, including 24 M. bovis and 4 NTMs from cattle, 1 M. tuberculosis and 1 NTM from camels and 9 NTMs from goats. Isolation of M. bovis from humans and M. tuberculosis from livestock suggests transmission between livestock and humans in the pastoral areas of South-East Ethiopia

Biology · Livestock · Mycobacterium bovis · Mycobacterium tuberculosis · Mycobacterium tuberculosis complex · Pastoralism · Pathology · Somali · Sputum · Tuberculosis · Veterinary medicine · Diagnosis and treatment of tuberculosis · Medicine · Mycobacterium research and diagnosis · Tuberculosis Research and Epidemiology · Ecology · Microbiology