Genomic and environmental risk factors for cardiometabolic diseases in Africa

Methods used for Phase 1 of the AWI-Gen population cross-sectional study

Datos Bibliográficos

ID19531237
AutoresStuart A Ali (0000-0002-4124-2896, University of the Witwatersrand), Cassandra Claire Soo (0000-0001-7043-8065, National Health Laboratory Service), Godfred Agongo (0000-0002-4218-5424, University of the Witwatersrand), Marianne Alberts (0000-0002-7628-8560, University of Limpopo), Lucas Amenga–Etego (0000-0003-4468-0506, Navrongo Health Research Centre), Palwendé Romuald Boua (0000-0001-8325-2665, National Health Laboratory Service), Ananyo Choudhury (0000-0001-8225-9531, University of the Witwatersrand), Nigel J Crowther (0000-0002-5766-1745, National Health Laboratory Service), Cornelius Debpuur (0000-0003-0968-5280), Cornelius Depuur (Navrongo Health Research Centre), Francesc Xavier Gómez-Olivé (0000-0002-4876-0848, University of the Witwatersrand), Issa Guiraud (0000-0002-6726-3898, Institut de Recherche en Sciences de la Santé), Tilahun Haregu (0000-0002-8797-0469, African Population and Health Research Center), Scott Hazelhurst (0000-0002-0581-149X, University of the Witwatersrand), Kathleen Kahn (0000-0003-3339-3931, University of the Witwatersrand), Christopher Khayeka-Wandabwa (0000-0002-9891-6046, African Population and Health Research Center), Catherine Kyobutungi (0000-0002-5344-5631, African Population and Health Research Center), Zané Lombard (0000-0002-7997-2616, National Health Laboratory Service), Felistas Mashinya (0000-0002-4132-7558, University of Limpopo), Lisa K Micklesfield (0000-0002-4994-0779, University of the Witwatersrand), Shukri F Mohamed (0000-0002-8693-1943, African Population and Health Research Center), Freedom Mukomana (0000-0003-0230-1379, University of the Witwatersrand), Seydou Nakanabo‐Diallo (0000-0003-4616-7845, Institut de Recherche en Sciences de la Santé), Hamtandi Magloire Natama (0000-0001-7411-077X, Institut de Recherche en Sciences de la Santé), Nicholas Ngomi (African Population and Health Research Center), Engelbert A Nonterah (0000-0001-8491-6478, University of the Witwatersrand), Shane A Norri (0000-0001-7124-3788, University of the Witwatersrand), Abraham Oduro (0000-0002-4191-7419, Navrongo Health Research Centre), Athanase M Somé (Institut de Recherche en Sciences de la Santé), Hermann Sorgho (0000-0003-1595-5152, Institut de Recherche en Sciences de la Santé), Paulina Tindana (0000-0002-9171-2083, Navrongo Health Research Centre), Halidou Tinto (0000-0002-0472-3586, Institut de Recherche en Sciences de la Santé), Rhian Twine (0000-0002-0766-6556, University of the Witwatersrand), Alisha N Wade (0000-0002-1158-2523, University of the Witwatersrand), Osman Sankoh (0000-0003-4405-9808, University of Sierra Leone), Michèle Ramsay (0000-0002-4156-4801, National Health Laboratory Service, autor de correspondencia)
Año2018
Volumen11
Númerosup2
Páginas1507133
Fecha de publicación2018-11-16
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaGlobal Health Action (JOURNAL)
Identificadores de la revistaISSN: 1654-9716 • E-ISSN: 1654-9880
EditorialInforma UK Limited (PUBLISHER • GB)
DOI10.1080/16549716.2018.1507133
PMID30259792
OpenAlexW2894074706
IdiomaEN
Citas recibidas11
Referencias citadas68

There is an alarming tide of cardiovascular and metabolic disease (CMD) sweeping across Africa. This may be a result of an increasingly urbanized lifestyle characterized by the growing consumption of processed and calorie-dense food, combined with physical inactivity and more sedentary behaviour. While the link between lifestyle and public health has been extensively studied in Caucasian and African American populations, few studies have been conducted in Africa. This paper describes the detailed methods for Phase 1 of the AWI-Gen study that were used to capture phenotype data and assess the associated risk factors and end points for CMD in persons over the age of 40 years in sub-Saharan Africa (SSA). We developed a population-based cross-sectional study of disease burden and phenotype in Africans, across six centres in SSA. These centres are in West Africa (Nanoro, Burkina Faso, and Navrongo, Ghana), in East Africa (Nairobi, Kenya) and in South Africa (Agincourt, Dikgale and Soweto). A total of 10,702 individuals between the ages of 40 and 60 years were recruited into the study across the six centres, plus an additional 1021 participants over the age of 60 years from the Agincourt centre. We collected socio-demographic, anthropometric, medical history, diet, physical activity, fat distribution and alcohol/tobacco consumption data from participants. Blood samples were collected for disease-related biomarker assays, and genomic DNA extraction for genome-wide association studies. Urine samples were collected to assess kidney function. The study provides base-line data for the development of a series of cohorts with a second wave of data collection in Phase 2 of the study. These data will provide valuable insights into the genetic and environmental influences on CMD on the African continent

Anthropometry · Cross-sectional study · Disease · Environmental health · Obesity · Pathology · Population · Public health · Demography · Global Public Health Policies and Epidemiology · Health, Environment, Cognitive Aging · Medicine · Obesity, Physical Activity, Diet · Gerontology · Internal Medicine