Regional hotspots for chronic kidney disease

A multinational study from the ISN-GKHA

Datos Bibliográficos

ID19590652
AutoresPablo García (0000-0001-6576-8078, University of New Mexico, autor de correspondencia), Anna K Strasma (0000-0001-5348-1707, Duke University, autor de correspondencia), Eranga Wijewickrama (0000-0002-1516-7263, National Hospital of Sri Lanka, autor de correspondencia), Silvia Arruebo (autor de correspondencia), Fergus Caskey (0000-0002-5199-3925, University of Bristol, autor de correspondencia), Sandrine Damster (autor de correspondencia), Jo-Ann Donner (0000-0002-5005-909X, autor de correspondencia), Vivekanand Jha (0000-0002-8015-9470, Manipal Academy of Higher Education, autor de correspondencia), Adeera Levin (0000-0003-2438-8401, University of British Columbia, autor de correspondencia), Masaomi Nangaku (0000-0001-7401-2934, The University of Tokyo, autor de correspondencia), Syed Saad (0000-0003-2059-7927, University of Alberta, autor de correspondencia), Marcello Tonelli (0000-0002-0846-3187, University of Calgary, autor de correspondencia), Feng Ye (0000-0002-1147-3271, University of Alberta, autor de correspondencia), Ikechi G Okpechi (0000-0002-6545-9715, University of Alberta, autor de correspondencia), Aminu K Bello (0000-0001-5021-5542, University of Alberta, autor de correspondencia), David W Johnson (0000-0001-5491-3460, Translational Research Institute, autor de correspondencia), Shuchi Anand (0000-0002-9892-8477, Stanford University, autor de correspondencia)
EditoresJulia Robinson (0000-0003-0719-3995)
Año2024
Volumen4
Número12
Páginase0004014
Fecha de publicación2024-12-05
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaPLOS Global Public Health (JOURNAL)
Identificadores de la revistaISSN: 2767-3375 • E-ISSN: 2767-3375
EditorialPublic Library of Science (PLoS) (PUBLISHER)
DOI10.1371/journal.pgph.0004014
PMID39636884
OpenAlexW4405057063
IdiomaEN
Referencias citadas32

Chronic kidney disease (CKD) disproportionately affects certain populations as demonstrated by well-established subnational geographic hotspots of CKD in Central America and South Asia. Using data from the third iteration of the International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA), we aimed to systematically identify sub-national geographic or population clusters with high prevalence of CKD. The ISN-GKHA survey was conducted from July to September 2022, and included questions regarding whether a regional CKD hotspot existed in the respondents’ country and possible contributors. A CKD hotspot was defined as a population cluster with a high risk of kidney failure requiring dialysis or transplant, or people dying from kidney failure. Overall, 46 out of 162 responding countries reported subnational hotspots for CKD within their country. Hotspots were reported across all regions, except for the Middle East. Latin America had the highest percentage (12 of 21, 57%) of countries reporting a regional CKD hotspot followed by the regions of North and East Asia, and Western Europe. Adults aged 18 to 44 years and rural populations were most commonly identified as the primary groups affected. Clinical factors were most commonly identified as contributors to CKD (hypertension in 74% and diabetes in 72%), followed by cultural (e.g., diet and herbal medications in 67%), and environmental (e.g., polluted water in 43%) factors. Latin American countries more commonly reported climate, cultural, and environmental factors as contributors compared to other regions. Across the world, there are a number of subnational regions where in-country experts identify a disproportionately higher burden of CKD, commonly occurring among younger age groups with clinical, cultural, and environmental contributors specific to these geographic regions. In-depth studies, starting with systematic epidemiology efforts, are needed to investigate the aetiopathogenesis of these CKD hotspots around the world so that tailored interventions can be offered

Environmental health · Geography · Kidney disease · Latin Americans · Multinational corporation · Political science · Population · Socioeconomics · Chronic Kidney Disease and Diabetes · Demography · Dialysis and Renal Disease Management · Healthcare Systems and Reforms · Medicine · Internal Medicine