Prevalence and factors associated with multidrug resistant Escherichia coli carriage on chicken farms in west Nile region in Uganda

A cross-sectional survey

Datos Bibliográficos

ID19590741
AutoresCeaser Adibaku Nyolimati (0009-0008-1592-2645, Infectious Diseases Institute, autor de correspondencia), Jonathan Mayito (0000-0001-9611-2178, Infectious Diseases Institute, autor de correspondencia), Emmanuel Obuya (0000-0002-0613-4734, Makerere University, autor de correspondencia), Atim Stella Acaye (Ministry of Agriculture, Animal Industry and Fisheries, autor de correspondencia), Emmanuel Isingoma (Ministry of Agriculture, Animal Industry and Fisheries, autor de correspondencia), Daniel Kibombo (0009-0003-5745-6754, Infectious Diseases Institute, autor de correspondencia), Dathan M Byonanebye (0000-0001-9862-4724, Infectious Diseases Institute, autor de correspondencia), Richard Walwema (0000-0003-0870-9009, Infectious Diseases Institute, autor de correspondencia), David Musoke (0000-0003-3262-3918, Makerere University, autor de correspondencia), Christopher Garimoi Orach (0000-0002-5209-5529, Makerere University, autor de correspondencia), Francis Kakooza (0000-0003-4047-6620, Infectious Diseases Institute, autor de correspondencia)
EditoresBen Pascoe (0000-0001-6376-5121)
Año2025
Volumen5
Número1
Páginase0003802
Fecha de publicación2025-01-16
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaPLOS Global Public Health (JOURNAL)
Identificadores de la revistaISSN: 2767-3375 • E-ISSN: 2767-3375
EditorialPublic Library of Science (PLoS) (PUBLISHER)
DOI10.1371/journal.pgph.0003802
PMID39820208
OpenAlexW4406495805
IdiomaEN
Referencias citadas28

Infections with multi-drug-resistant (MDR) pathogens in food-animals threaten public health and food security. However, the epidemiology and factors associated with MDR Escherichia coli (MDR E . coli ) on Ugandan farms are not well known. This study investigated the prevalence, resistance patterns and factors associated with MDR E . coli carriage on chicken farms. Escherichia coli was isolated from each of the 158 chicken farms sampled. The disc diffusion method for susceptibility testing was performed. Clinical breakpoints were interpreted according to Clinical and Laboratory Standards Institute guidelines. MDR was defined as resistance to three or more classes of antibiotics. MDR E . coli prevalence on chicken farms was 62.7% (95% CI: 55.0–70.3). High resistance was observed against ampicillin 79.8% (95% CI: 72.7–85.4), tetracycline 72.8% (95% CI: 65.2–79.2), cotrimoxazole 55.7% (95% CI: 47.8–63.3), and ciprofloxacin 38% (95% CI: 30.7–45.9). Male farm managers (Adjusted prevalence ratio [APR] = 0.72, CI: 0.55–0.93), attainence of at least secondary education (APR = 0.64, CI: 0.46–0.88) and administration of recommended antibiotic doses (APR = 0.76, CI: 0.59–0.96) posed a lower risk of MDR E . coli carriage while farms without footbaths posed a heighten risk (APR = 1.48, CI: 1.16–1.88). MDR E . coli carriage was highly prevalent on chicken farms in Uganda. This study underscores the urgent need for antimicrobial stewardship and improved infection prevention strategies on chicken farms

Biology · Carriage · Cross-sectional study · Drug resistance · Environmental health · Escherichia coli · Multiple drug resistance · Pathology · Veterinary medicine · Antibiotic Resistance in Bacteria · Escherichia coli research studies · Medicine · Salmonella and Campylobacter epidemiology · Genetics · Microbiology · Virology