Aflatoxicosis outbreak and its associated factors in Kiteto, Chemba and Kondoa Districts, Tanzania

Datos Bibliográficos

ID19590933
AutoresErick S Kinyenje (0000-0001-8434-2232, Muhimbili University of Health and Allied Sciences, autor de correspondencia), Rogath Kishimba (0000-0002-5437-7589, autor de correspondencia), Mohamed Mohamed (0000-0002-2447-5639, autor de correspondencia), Ambele Mwafulango (autor de correspondencia), Eliudi S Eliakimu (0000-0003-2383-9530, Ministry of Health, Community Development, Gender, Elderly and Children, autor de correspondencia), Eliudi Eliakimu, G Kwesigabo (0000-0003-3302-6736, Muhimbili University of Health and Allied Sciences, autor de correspondencia)
EditoresReuben Kiggundu (0000-0001-6141-9436)
Año2023
Volumen3
Número8
Páginase0002191
Fecha de publicación2023-08-08
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaPLOS Global Public Health (JOURNAL)
Identificadores de la revistaISSN: 2767-3375 • E-ISSN: 2767-3375
EditorialPublic Library of Science (PLoS) (PUBLISHER)
DOI10.1371/journal.pgph.0002191
PMID37552664
OpenAlexW4385655393
IdiomaEN
Citas recibidas2
Referencias citadas51

Tanzania had experienced hundreds of cases of aflatoxicosis in the districts of Kiteto, Chemba, and Kondoa for the three consecutive years since 2016. Cases may end up with liver cancer. Aflatoxin-induced liver cancer had resulted in the demise of roughly three persons per 100,000 in the country during the same year, 2016. We investigated to characterize the latest outbreak of 2019 and identify its risk factors. This case-control study enrolled all patients presented with acute jaundice of unknown origin and laboratory test results confirmed an acute liver injury with or without abdominal pain, distension, vomiting, or fever during the period of June to November 2019 and had epidemiological link with cases confirmed with Aflatoxin-B1-Lysine. Adjusted odds ratios (AOR) with 95% confidence intervals (CI) were used to identify independent factors associated with aflatoxicosis. We analyzed 62 cases with median age of 7 years (0.58–50 years) and 186 controls with median age of 24 years (range 0.42–55) with onset of symptoms ranging from 1 st June 2019 to 16 th July 2019. Case-parents had higher serum aflatoxin-B1–lysine adduct concentrations than did controls; 208.80 ng/mg (n = 45) vs. 32.2 ng/mg (n = 26); p

Aflatoxin · Biology · Confidence interval · Jaundice · Odds ratio · Outbreak · Pathology · Vomiting · Medicine · Mycotoxins in Agriculture and Food · Plant Pathogens and Resistance · Wheat and Barley Genetics and Pathology · Biotechnology · Epidemiology · Gastroenterology · Internal Medicine