Antiprotozoal Activity of Extracts of Elaeodendron Trichotomum (Celastraceae)

Datos Bibliográficos

ID20347013
AutoresCarolina Roca-Mézquita, Carolina Roca-Mézquita (Autonomous University of Yucatán), Manlio Graniel-Sabido (Autonomous University of Yucatán), Rosa E Moo-Puc, Rosa Moo‐Puc (0000-0001-9204-6062, Secretaría de Investigación, Innovación y Educación Superior), Lorena V Leon-Déniz, Lorena V Leon-Déniz, Rubí Gamboa-LeÃ3n, Rubí Gamboa-Leà n, Rubí Gamboa-León, Carely Arjona-Ruiz (0000-0003-3706-2072, Universidad de Tamazunchale), Juan Tun-Garrido, Juan Tun‐Garrido (0000-0001-8796-3405, Autonomous University of Yucatán), Gumersindo MirÃ3n-LÃ3pez, Gumersindo Mirà n-Là pez (Autonomous University of Yucatán), Gonzalo J Mena-Rejon, Gonzalo J Mena‐Rejón (0000-0003-4248-2274, Autonomous University of Yucatán)
Año2016
Volumen13
Número4
Páginas162-165
Fecha de publicación2016-07-03
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaAfrican Journal of Traditional Complementary and Alternative Medicines (JOURNAL)
Identificadores de la revistaISSN: 0189-6016 • E-ISSN: 2505-0044
EditorialAfrican Traditional Herbal Medicine Supporters Initiative (ATHMSI) (PUBLISHER)
DOI10.21010/ajtcam.v13i4.21
PMID28852732
OpenAlexW2337969708
IdiomaEN
Citas recibidas1
Referencias citadas3

Background: Chagas disease, amebiasis, giardiasis and trichomoniasis represent a serious health problem in Latin America. The drugs employed to treat these illnesses produce important side effects and resistant strains have appeared. The present study was aimed to evaluate the antiprotozoal activity of leaves, stem bark and root bark of Elaeodendron trichotomum, a celastraceus, that is used in Mexico as an anti-infective in febrile-type diseases. Materials and methods: Dichloromethane and methanol extracts of leaves, bark and roots of Elaeodendron trichotomum were tested against Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, and Trypanosoma cruzi. A quantitative HPLC analysis of pristimerin and tingenone was performed. Results: The dichloromethane extract of roots was active against E. histolytica, G. lamblia, T. vaginalis, and T. cruzi, at IC50’s of 0.80, 0.44, 0.46, and 2.68 μg/mL, respectively. The HPLC analysis revealed the presence of tingenone (3.84%) and pristimerin (0.14%). Conclusions: The dichloromethane extract of the roots bark showed significant activity against all screened protozoa

Antiprotozoal · Biology · Botany · Dichloromethane · Entamoeba histolytica · Giardia lamblia · In vitro · Parasite hosting · Traditional medicine · Trichomoniasis · Trypanosoma cruzi · Bioactive Compounds and Antitumor Agents · Medicine · Phytochemical compounds biological activities · Research on Leishmaniasis Studies · Biochemistry · Microbiology