The total triterpenoid extract of Prunella vulgaris exerts anti-inflammatory effects by suppressing the NF-κB/TLR/TNF-α signaling axis in Lipopolysaccharide-stimulated RAW264.7 cells
Datos Bibliográficos
| ID | 21544071 |
|---|---|
| Autores | Zhimei Hu (Hubei University of Chinese Medicine), Lei Xu (0009-0000-3744-0753, Hubei University of Chinese Medicine), Zhonghua Du (0000-0002-8673-5926, Hubei University of Chinese Medicine), Junjie Hu (0000-0003-3557-0452, Hubei University of Chinese Medicine), Yan Meng (0000-0002-0614-8968, Hubei University of Chinese Medicine), Shilei Wang (0000-0003-3162-8231, Hubei University of Chinese Medicine), Lichun Ye (Hubei University of Chinese Medicine, autor de correspondencia), Zhaohua Shi (0000-0002-4640-5076, Hubei University of Chinese Medicine, autor de correspondencia) |
| Año | 2026 |
| Volumen | 356 |
| Páginas | 120778 |
| Fecha de publicación | 2026-02-01 |
| Peer Reviewed | Sí |
| Open Access | Sí |
| Tipo | ARTICLE |
| Revista | Journal of Ethnopharmacology (JOURNAL) |
| Identificadores de la revista | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Editorial | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2025.120778 |
| PMID | 41139040 |
| OpenAlex | W4415459654 |
| Idioma | EN |
| Referencias citadas | 48 |
This study provides a green and efficient extraction and purification process for PVTH. Through this process, PVTH with a purity of 65.42 % was prepared. Additionally, the study analyzed the composition of PVTH and conducted an in-depth investigation into its anti-inflammatory activity, mechanism of action, and in vivo anti-inflammatory efficacy. These results highlight the therapeutic potential of PVTH in inflammatory diseases and provide a basis for further research on P. vulgaris L. in fields such as cosmetics and functional foods
Cosmetics · Cytotoxicity · Extraction (chemistry) · Folk medicine · In vivo · Pharmacognosy · Prunella vulgaris · Triterpenoid · Biological Activity of Diterpenoids and Biflavonoids · Natural product bioactivities and synthesis · Pharmacological Effects of Natural Compounds · Plant Toxicity and Pharmacological Properties
Phytochemical determination and mechanistic investigation of Polygala tenuifolia root (Yuanzhi) extract for bronchitis
Chemical profiling and in-vitro anti-inflammatory activity of bioactive fraction(s) from Trichodesma indicum (L.) R.Br. against LPS induced inflammation in RAW 264.7 murine macrophage cells
Anti-inflammatory effects of Elsholtzia ciliata extract on Poly I
Effect and mechanism of Prunella vulgaris L. extract on alleviating lipopolysaccharide-induced acute mastitis in protecting the blood-milk barrier and reducing inflammation
Modulation of glycolytic metabolic reprogramming and the TLR4/NF-κB/NLRP3 Pathway
Opuntia monacantha
Anti-inflammatory effects of three withanolides isolated from Physalis angulata L. in LPS-activated RAW 264.7 cells through blocking NF-κB signaling pathway
The anti-inflammatory effects of paeonol from Cynanchum paniculatum extracts on LPS-induced macrophage RAW 264.7 cells and Helicobacter pylori-infected gastrointestinal mucosal damaged zebrafish
Screening out the anti-insomnia components from Prunella vulgaris L. based on plasma pharmacochemistry combined with pharmacodynamic experiments and UPLC-MS/MS analysis
| Velocidad de citación | historical |
|---|---|
| Altamente citado | No |