Buprenorphine Treatment Intake and Critical Encounters following a Nonfatal Opioid Overdose

Datos Bibliográficos

ID21645929
AutoresGrant Victor (0000-0003-1654-5294, Wayne State University, autor de correspondencia), Katie Bailey (0000-0002-4794-117X, Wayne State University), B Ray (0000-0003-3643-775X, Wayne State University)
Año2021
Volumen56
Número7
Páginas988-996
Fecha de publicación2021-06-07
Peer ReviewedSí
Open AccessNo
TipoARTICLE
RevistaSubstance Use & Misuse (JOURNAL)
Identificadores de la revistaISSN: 1082-6084 • E-ISSN: 1532-2491
EditorialInforma UK Limited (PUBLISHER • GB)
DOI10.1080/10826084.2021.1901933
PMID33749520
OpenAlexW3138004878
IdiomaEN
Citas recibidas3
Referencias citadas67

Background Individuals with prior opioid-related overdose events have an increased risk for opioid-related mortality. Buprenorphine is a partial agonist that has shown to be an effective medication for opioid use disorder (MOUD). Yet, few studies have investigated whether buprenorphine reduces the risk of opioid-related mortality following a nonfatal opioid-related overdose.Methods A retrospective study was conducted on all overdose cases in Indiana between January 1, 2017 and December 31, 2017. Data were linked from multiple administrative sources. Cases were linked to vital records to assess mortality. Bivariate analyses were conducted to assess group differences between survivors and decedents. A series of multiple logistic regression models were used to determine main and interaction effects of opioid-related mortality.Results Among the 10,195 nonfatal overdoses, 2.4% (247) resulted in a subsequent fatal overdose. Overdose decedents were on average 36.4 years-old, 66.8% male, 91.1% White, and 83.8% did not receive a buprenorphine dispensation. Incremental increases in the number of buprenorphine dispensations decreased the likelihood of fatal overdose by 94% (95% CI = 0.88-0.98, p = .001). Incremental increases in arrest encounters were found to significantly increase the likelihood of a fatal overdose (AOR = 2.16; 95% CI = 1.13-3.55). Arrest encounters were a significant moderator of the relationship between buprenorphine uptake effectiveness and drug-related mortality.Conclusions Analysis of linked data provided details of risk and protective factors of fatal overdose. Buprenorphine reduced the risk of death; however, criminal justice involvement remains an area of attention for diversion and overdose death prevention interventions

Anesthesia · Buprenorphine · Drug overdose · Logistic regression · Methadone · Opioid · Opioid overdose · Opioid use disorder · Poison control · Retrospective cohort study · HIV, Drug Use, Sexual Risk · Medicine · Opioid Use Disorder Treatment · Suicide and Self-Harm Studies · Emergency Medicine · Internal Medicine