Untargeted and targeted fortified balanced energy-protein (BEP) dietary supplementation during pregnancy and birth outcomes

A cluster-randomised effectiveness trial in rural Bangladesh

Datos Bibliográficos

ID21880688
AutoresPolly Christian (0000-0002-2908-1030, Johns Hopkins University), Parul Christian (Johns Hopkins University), Hasmot Ali (0000-0003-0044-1992, Johns Hopkins University), Eleonor Zavala (0000-0002-8457-0259, Johns Hopkins University), Diwakar Mohan (0000-0002-7532-366X, Johns Hopkins University), Towfida Jahan Siddiqua (0000-0002-1668-8538, Johns Hopkins University), Rezwanul Haque (0000-0002-4693-3119, The JiVitA Project, Rangpur, Bangladesh), Hasan Mahmud Sujon (0000-0001-5693-3828), Hasan M Sujan (The JiVitA Project, Rangpur, Bangladesh), Kaniz Ayesha (The JiVitA Project, Rangpur, Bangladesh), Lee S F Wu (Johns Hopkins University), Brian Dyer (0000-0001-9178-1807, Johns Hopkins University), Daniel J Erchick (0000-0002-2852-280X, Johns Hopkins University), Andrew L Thorne-Lyman (Johns Hopkins University), Kaosar Afsana (0000-0002-5197-8151, BRAC University)
Año2026
Volumen11
Número6
Páginase023766
Fecha de publicación2026-06-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaBMJ Global Health (JOURNAL)
Identificadores de la revistaISSN: 2059-7908 • E-ISSN: 2059-7908
EditorialBMJ (PUBLISHER • GB)
DOI10.1136/bmjgh-2026-023766
PMID42349909
OpenAlexW7165890934
IdiomaEN
Referencias citadas21

Antenatal balanced energy-protein (BEP) dietary supplementation is a WHO recommendation in undernourished settings, but limited evidence exists on targeting individuals based on nutritional status. We assessed the impact of untargeted and targeted fortified BEP supplementation during pregnancy on birth outcomes, compared with multiple micronutrient supplements (MMS) as control. In a four-arm, cluster-randomised controlled trial pregnant women received daily: (1) MMS (control); (2) BEP; (3) BEP for those with prepregnancy body mass index (BMI) From October 2022 to November 2024, 3390 pregnant women were enrolled, supplemented and followed in the trial. 2950 women had 2976 live births with 2674 measured within 72 hours of birth. Baseline characteristics did not differ by arm and median adherence was 93%. In the control arm the mean (SD) birth weight was 2763 (383) g, and the incidence of SGA and LBW was 41.4% and 23.4%. Untargeted and targeted BEP supplementation did not differ from the control for primary and secondary outcomes. A higher weight-for-gestational age centile (3.7%, 98.3% CI 0.6% to 6.7%) was seen in the arm targeting low BMI and IGWG. Higher benefits were seen in BEP arms with lower than median adherence compared with the same stratum in the MMS arm and BEP reduced SGA and LBW among anaemic women. In this high burden Bangladeshi setting, antenatal supplementation with fortified BEP, untargeted or targeted, did not reduce fetal growth restriction and small size at birth when compared with MMS

Birth weight · Body mass index · Gestation · Gestational age · Micronutrient · Nutritional Supplementation · Pregnancy · Child Nutrition and Water Access · Gestational Diabetes Research and Management · Iron Metabolism and Disorders