Human Serum Albumin Cys34 Adducts in Newborn Dried Blood Spots

Background: Increasing evidence suggests that exposure to air pollution during pregnancy is associated with adverse pregnancy outcomes. However, biomarkers associated with air pollution exposure are widely lacking and often transient. In addition, ascertaining biospecimens during pregnacy to assess the prenatal environment remains largely infeasible. Objectives: To address these challenges, we investigated relationships between air pollution exposure during pregnancy and human serum albumin Cys 34 (HSA-Cys 34 ) adducts in newborn dried blood spots (DBS) samples, which captures an integration of perinatal exposures to small reactive molecules in circulating blood. Methods: Newborn DBS were obtained from a state archive for a cohort of 120 children born at one Kaiser Permanente Southern California (KPSC) hospitals in 2007. These children were selected to maximize the range of residential air pollution exposure during the entire pregnancy to PM 2.5 , PM 10 , NO 2 , O 3 , based on monthly estimates interpolated from regulatory monitoring sites. HSA-Cys 34 adducts were selected based on previously reported relationships with air pollution exposure and oxidative stress. Results: Six adducts measured in newborn DBS samples were associated with air pollution exposures during pregnancy; these included direct oxidation products, adducts formed with small thiol compounds, and adducts formed with reactive aldehydes. Two general trends were identified: Exposure to air pollution late in pregnancy (i.e., in the last 30 days) was associated with increased oxidative stress, and exposure to air pollution earlier in pregnancy (i.e., not in the last 30 days) was associated with decreased oxidative stress around the time of birth. Discussion: Air pollution exposure occurring during pregnancy can alter biology and leave measurable impacts on the developing infant captured in the newborn DBS adductome, which represents a promising tool for investigating adverse birth outcomes in population-based studies

Albumin · Biology · Chromatography · Dried blood · Obstetrics · Pathology · Pregnancy · Spots · Air Quality and Health Impacts · Chemistry · Climate Change and Health Impacts · Health, Environment, Cognitive Aging · Medicine · Biochemistry · Genetics

• Analysis of Environmental and Social Significant Factors Affecting the Flow of Maternal Patients in Jilin, China

  Open Access•Dongmei Mu, Hua Li et al.•Frontiers in Public Health•2022

  Añadir item

• Ambient air pollution, birth weight and preterm birth

  Open Access•David M Stieb, Li Chen et al.•Environmental Research•2012

  Añadir item

• Increasing statistical power without increasing sample size

  Gary H Mcclelland•American Psychologist•2000

  Añadir item