Relationship between maternal exposure to heavy metal titanium and offspring congenital heart defects in Lanzhou, China

A nested case-control study

Datos Bibliográficos

ID22073135
AutoresJianhao Sun (Gansu University of Traditional Chinese Medicine), Baohong Mao (0000-0002-9795-9589, Gansu Provincial Maternal and Child Health Hospital), Zhenzhen Wu (0000-0003-4384-3473, Gansu Provincial Maternal and Child Health Hospital), Xinjuan Jiao (Gansu University of Traditional Chinese Medicine), Yanxia Wang (0000-0001-6045-4643, Gansu Provincial Maternal and Child Health Hospital), Yongli Lu (0000-0002-8316-8794, Gansu University of Traditional Chinese Medicine), Xue‐Jing Ma (0000-0003-0217-1121, Gansu University of Traditional Chinese Medicine), Xuejing Ma (0000-0002-9313-6446), Xiaohui Liu (0000-0003-4988-7469, Gansu Provincial Maternal and Child Health Hospital), Xiaoying Xu (0000-0001-5149-9487, Gansu Provincial Maternal and Child Health Hospital), Hongmei Cui (0000-0002-9356-1506), Hongda Cui (0009-0003-5498-4762, Gansu Provincial Maternal and Child Health Hospital), Xiaojuan Lin (0000-0001-6474-9609, Gansu Provincial Maternal and Child Health Hospital), Bin Yi (0000-0002-9343-2616, Gansu Provincial Maternal and Child Health Hospital), Jie Qiu (0000-0002-9680-135X, Gansu Provincial Maternal and Child Health Hospital), Qing Liu (0000-0002-5792-6037, Gansu University of Traditional Chinese Medicine, autor de correspondencia)
Año2022
Volumen10
Páginas946439-946439
Fecha de publicación2022-08-03
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaFrontiers in Public Health (JOURNAL)
Identificadores de la revistaISSN: 2296-2565 • E-ISSN: 2296-2565
EditorialFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2022.946439
PMID35991008
OpenAlexW4289516564
IdiomaEN
Citas recibidas3
Referencias citadas37

Background: Previous studies have found that exposure to heavy metals increased the incidence of congenital heart defects (CHDs). However, there is a paucity of information about the connection between exposure to titanium and CHDs. This study sought to examine the relationship between prenatal titanium exposure and the risk of CHDs in offspring. Methods: We looked back on a birth cohort study that was carried out in our hospital between 2010 and 2012. The associations between titanium exposure and the risk of CHDs were analyzed by using logistic regression analysis to investigate titanium concentrations in maternal whole blood and fetal umbilical cord blood. Results: )] of titanium were 371.91 (188.85, 659.15) μg/L and 370.43 (264.86, 459.76) μg/L in serum titanium levels in pregnant women and in umbilical cord serum titanium content in the CHDs group, respectively. There was a moderate positive correlation between the concentration of titanium in pregnant women's blood and that in umbilical cord blood. A higher concentrations of maternal blood titanium level was associated with a greater risk of CHDs (OR 2.706, 95% CI 1.547-4.734), the multiple CHDs (OR 2.382, 95% CI 1.219-4.655), atrial septal defects (OR 2.367, 95% CI 1.215-4.609), and patent ductus arteriosus (OR 2.412, 95% CI 1.336-4.357). Dramatically higher concentrations of umbilical cord blood levels had an increased risk of CHDs and different heart defects. Conclusion: Titanium can cross the placental barrier and the occurrence of CHDs may be related to titanium exposure

Biology · Case-control study · China · Environmental health · Geography · Nested case-control study · Offspring · Pregnancy · Aluminum toxicity and tolerance in plants and animals · Heavy Metal Exposure and Toxicity · Heavy metals in environment · Medicine · Genetics · Internal Medicine