Trends in incidence, mortality, and Dalys of cystic echinococcosis in Central Asia from 1992 to 2021

An age-period-cohort analysis

Datos Bibliográficos

ID22085541
AutoresWulan Talafuhan (Xinjiang Medical University), Kaibinuer Tuoheti (Xinjiang Medical University), Lixia Ye (0000-0002-6201-3224, Xinjiang Medical University), Ye Lixia, Shuang Qi (0000-0002-7873-3701, Xinjiang Medical University), Qi Shuang, Mieyier Yeerjiang (Xinjiang Medical University), Guzalinuer Aizezi (Xinjiang Medical University), Wei Jingjing (Xinjiang Medical University, autor de correspondencia), Peierdun Mijiti (Xinjiang Medical University, autor de correspondencia)
Año2025
Volumen12
Páginas1504481-1504481
Fecha de publicación2025-01-23
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaFrontiers in Public Health (JOURNAL)
Identificadores de la revistaISSN: 2296-2565 • E-ISSN: 2296-2565
EditorialFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2024.1504481
PMID39959907
OpenAlexW4406774550
IdiomaEN
Referencias citadas31

Background: Cystic echinococcosis (CE) is widespread globally but imposes a particularly heavy burden in Central Asia. Despite control measures, disease management remains suboptimal in this region. This study analyzed trends in CE incidence, mortality, and disability-adjusted life years (DALYs) from 1992 to 2021 in Central Asia; compared them with global data; and explored variations by gender, age group, and country to identify critical factors in disease control. Methods: Using data from the Global Burden of Disease Study 2021 (GBD 2021), we analyzed long-term trends in the incidence, mortality, and DALY rates of CE in Central Asia. The joinpoint regression model was employed to calculate the annual percentage change (APC) and average APC (AAPC) to identify shifts in disease trends. Additionally, an age-period-cohort model was used to assess the impact of various age groups, periods, and birth cohorts on the disease burden. Results: The number of CE cases increased by 52.13% in Central Asia, while deaths decreased by 57.35%; DALYs decreased only slightly by 10.75%. From 1992 to 2021, CE incidence showed an increasing trend until 2010, then rapidly declined until 2015, and then gradually increased thereafter. The highest incidence rates were among middle-aged and older adult populations. Although mortality and DALY rates decreased across all age groups, the decline was less than the global trend. Gender analysis showed that the incidence rate was significantly higher in males than in females. Conclusion: Although there have been improvements in the CE disease burden in some Central Asian countries, the overall burden remains significant. This study highlights the importance of considering gender, age, and country-specific disease burdens when formulating public health policies. Future research should continue to monitor these trends and explore targeted prevention strategies within diverse socioeconomic contexts, such as integrating regional socioeconomic factors and public health resources

Burden of disease · Central asia · Cohort · Cohort study · Disease · Disease burden · Geography · Mortality rate · Demography · Medicine · Parasites and Host Interactions · Parasitic Infections and Diagnostics · Parasitic infections in humans and animals · Internal Medicine · Surgery