Travel- and Community-Based Transmission of Multidrug-Resistant Shigella sonnei Lineage among International Orthodox Jewish Communities

Datos Bibliográficos

ID23174353
AutoresKate S Baker (0000-0001-5850-1949, Centers for Disease Control and Prevention), Timothy J Dallman (0000-0001-7105-2543, Centers for Disease Control and Prevention), Adi Behar (0000-0002-9640-1495, Centers for Disease Control and Prevention), François‐Xavier Weill (0000-0001-9941-5799, Centers for Disease Control and Prevention), François-Xavier Weill, Malika Gouali (Centers for Disease Control and Prevention), Jeremy Sobel (0000-0003-4699-9975, Centers for Disease Control and Prevention), María Fookes (Centers for Disease Control and Prevention), Lea Valinsky (Centers for Disease Control and Prevention), Ohad Gal‐Mor (0000-0002-2540-6790, Centers for Disease Control and Prevention), Ohad Gal-Mor, Thomas R Connor (0000-0003-2394-6504, Centers for Disease Control and Prevention), Israel Nissan (0000-0001-6726-5052, Centers for Disease Control and Prevention), Sophie Bertrand (0000-0002-4170-5168, Centers for Disease Control and Prevention), Julian Parkhill (0000-0002-7069-5958, Centers for Disease Control and Prevention), Claire Jenkins (0000-0002-8892-1511, Centers for Disease Control and Prevention), Dani Cohen (0000-0003-2664-2303, Centers for Disease Control and Prevention), Nicole Renick Thomson (0000-0002-4432-8505, Centers for Disease Control and Prevention), Nicholas R Thomson
Año2016
Volumen22
Número9
Páginas1545-1553
Fecha de publicación2016-09-01
Open AccessSí
TipoARTICLE
RevistaEmerging infectious diseases (JOURNAL)
Identificadores de la revistaISSN: 1080-6040 • E-ISSN: 1080-6059
EditorialCenters for Disease Control and Prevention (CDC) (PUBLISHER • US)
DOI10.3201/eid2209.151953
PMID27532625
OpenAlexW2482384689
IdiomaEN
Referencias citadas30

Shigellae are sensitive indicator species for studying trends in the international transmission of antimicrobial-resistant Enterobacteriaceae. Orthodox Jewish communities (OJCs) are a known risk group for shigellosis; Shigella sonnei is cyclically epidemic in OJCs in Israel, and sporadic outbreaks occur in OJCs elsewhere. We generated whole-genome sequences for 437 isolates of S. sonnei from OJCs and non-OJCs collected over 22 years in Europe (the United Kingdom, France, and Belgium), the United States, Canada, and Israel and analyzed these within a known global genomic context. Through phylogenetic and genomic analysis, we showed that strains from outbreaks in OJCs outside of Israel are distinct from strains in the general population and relate to a single multidrug-resistant sublineage of S. sonnei that prevails in Israel. Further Bayesian phylogenetic analysis showed that this strain emerged approximately 30 years ago, demonstrating the speed at which antimicrobial drug-resistant pathogens can spread widely through geographically dispersed, but internationally connected, communities.

Biology · Context (archaeology) · Drug resistance · Environmental health · Gene · Geography · Lineage (genetic) · Multiple drug resistance · Outbreak · Phylogenetic tree · Population · Salmonella · Shigella · Shigella sonnei · Shigellosis · Transmission (telecommunications) · Genetics · Jewish and Middle Eastern Studies · Medicine · Microbiology · Virology