Vulnerability genes or plasticity genes?
Datos Bibliográficos
| ID | 23328401 |
|---|---|
| Autores | J Belsky (0000-0003-2191-2503, Birkbeck, University of London, autor de correspondencia), Charles R Jonassaint (0000-0002-5662-5806, Duke University), C Jonassaint, Michael Plue (0000-0001-5071-2047, Birkbeck, University of London), M Pluess, Michael Stanton (0000-0002-8142-6569, Duke University), Beverly H Brummett (Duke Medical Center), B Brummett, R Williams (0000-0003-3549-1244), Raymond Brady Williams (0000-0002-8581-0648, Duke Medical Center) |
| Año | 2009 |
| Volumen | 14 |
| Número | 8 |
| Páginas | 746-754 |
| Fecha de publicación | 2009-08-01 |
| Peer Reviewed | Sí |
| Open Access | Sí |
| Tipo | ARTICLE |
| Revista | Molecular Psychiatry (JOURNAL) |
| Identificadores de la revista | ISSN: 1359-4184 • E-ISSN: 1476-5578 |
| Editorial | Springer Science and Business Media LLC (PUBLISHER) |
| DOI | 10.1038/mp.2009.44 |
| PMID | 19455150 |
| PMCID | PMC2834322 |
| OpenAlex | W2104281323 |
| Idioma | EN |
| Citas recibidas | 81 |
| Referencias citadas | 49 |
The classic diathesis-stress framework, which views some individuals as particularly vulnerable to adversity, informs virtually all psychiatric research on behavior-gene-environment (G x E) interaction. An alternative framework of 'differential susceptibility' is proposed, one which regards those most susceptible to adversity because of their genetic make up as simultaneously most likely to benefit from supportive or enriching experiences-or even just the absence of adversity. Recent G x E findings consistent with this perspective and involving monoamine oxidase-A, 5-HTTLPR (5-hydroxytryptamine-linked polymorphic region polymorphism) and dopamine receptor D4 (DRD4) are reviewed for illustrative purposes. Results considered suggest that putative 'vulnerability genes' or 'risk alleles' might, at times, be more appropriately conceptualized as 'plasticity genes', because they seem to make individuals more susceptible to environmental influences-for better and for worse.
Biology · Computational biology · Gene · Vulnerability (computing) · Birth, Development, and Health · Cognitive Abilities and Testing · Computer Science · Genetics · Psychology · Resilience and Mental Health
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| Obras citantes distintas | 81 |
|---|---|
| Citas por año | 3,12 |
| Intervalo de citas | 2000 - 2026 (27) |
| Velocidad de citación | current |
| Altamente citado | No |
| Tipos de cita | Neutras: 69 |