Investigating the impact of poverty on mental illness in the UK Biobank using Mendelian randomization
Datos Bibliográficos
| ID | 4635608 |
|---|---|
| Autores | M Marchi (0000-0003-2970-1276, University of Modena and Reggio Emilia), Anne Alkema (0000-0003-2440-7019, Utrecht University), Charley Xia (0000-0002-8194-9351, NHS Lothian), Chris H L Thio (0000-0003-2623-7172, University Medical Center Groningen), Li-Yu Chen (0000-0002-5418-6782, Utrecht University), Winni Schalkwijk (0009-0000-6627-6681, Utrecht University), Gian Maria Galeazzi (0000-0003-2706-3362, University of Modena and Reggio Emilia, autor de correspondencia), Silvia Ferrari (0000-0001-7929-4520, University of Modena and Reggio Emilia), Luca Pingani (0000-0003-3428-8308, University of Modena and Reggio Emilia), Hyeokmoon Kweon (0000-0002-3649-0457, Vrije Universiteit Amsterdam), Sara Evans-Lacko (0000-0003-4691-2630, London School of Economics and Political Science), Warren D Hill (0000-0001-7205-1606, NHS Lothian), Marco P Boks (0000-0001-6163-7484, Utrecht University, autor de correspondencia) |
| Año | 2024 |
| Volumen | 8 |
| Número | 9 |
| Páginas | 1771-1783 |
| Fecha de publicación | 2024-07-10 |
| Peer Reviewed | Sí |
| Open Access | Sí |
| Tipo | ARTICLE |
| Revista | Nature Human Behaviour (JOURNAL) |
| Identificadores de la revista | ISSN: 2397-3374 • E-ISSN: 2397-3374 |
| Editorial | Springer Science and Business Media LLC (PUBLISHER) |
| DOI | 10.1038/s41562-024-01919-3 |
| PMID | 38987359 |
| OpenAlex | W4400503103 |
| Idioma | EN |
| Citas recibidas | 11 |
| Referencias citadas | 93 |
It is unclear whether poverty and mental illness are causally related. Using UK Biobank and Psychiatric Genomic Consortium data, we examined evidence of causal links between poverty and nine mental illnesses (attention deficit and hyperactivity disorder (ADHD), anorexia nervosa, anxiety disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, obsessive-compulsive disorder, post-traumatic stress disorder and schizophrenia). We applied genomic structural equation modelling to derive a poverty common factor from household income, occupational income and social deprivation. Then, using Mendelian randomization, we found evidence that schizophrenia and ADHD causally contribute to poverty, while poverty contributes to major depressive disorder and schizophrenia but decreases the risk of anorexia nervosa. Poverty may also contribute to ADHD, albeit with uncertainty due to unbalanced pleiotropy. The effects of poverty were reduced by approximately 30% when we adjusted for cognitive ability. Further investigations of the bidirectional relationships between poverty and mental illness are warranted, as they may inform efforts to improve mental health for all
Biobank · Biology · Mendelian randomization · Mental health · Mental illness · Political science · Poverty · Psychiatry · Genetic Associations and Epidemiology · Health disparities and outcomes · Liver Disease Diagnosis and Treatment · Medicine · Psychology · Genetics · Gerontology
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| Obras citantes distintas | 11 |
|---|---|
| Citas por año | 11 |
| Intervalo de citas | 2025 - 2026 (2) |
| Velocidad de citación | current |
| Altamente citado | No |
| Tipos de cita | Neutras: 11 |